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PWV of left lower and upper extremities were measured in DM2 (7 m\/8 f, age 68\u00b110 years, BP 158\/90\u00b119\/9 mm Hg) and healthy controls (5 m\/6 f, age 23\u00b12 years, BP 117\/76\u00b19\/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45\u00b0 (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.<\/jats:p>","DOI":"10.33549\/physiolres.934594","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T13:32:38Z","timestamp":1611754358000},"page":"S433-S441","source":"Crossref","is-referenced-by-count":9,"title":["Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge"],"prefix":"10.33549","author":[{"given":"J","family":"SVA\u010cINOV\u00c1","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"HRU\u0160KOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"JAKUB\u00cdK","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"BUDINSKAYA","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"HIDEGOV\u00c1","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"FAB\u0160\u00cdK","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"SIEGLOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"KA\u0160\u010c\u00c1KOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"NOV\u00c1K","sequence":"additional","affiliation":[{"name":"Second Department of Internal medicine, St. Anne\u00b4s Faculty Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"NOV\u00c1KOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BODE AS, LEERMAKERS J, KROON JW, BRANDS P, PLANKEN RN, TORDOIR JHM: Determination of brachial artery stiffness prior to vascular access creation: reproducibility of pulse wave velocity assessment. 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