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Pregnant rats were exposed to a mixture of diethylhexyl, diisononyl and dibutyl phthalate, each at a dose of 4.5 mg\/kg\/day, from gestational day 15 to postnatal day 4. A social interaction test was performed to assess sociability in the three ontogenetic stages (weaning, puberty, adulthood). AGD was measured in adulthood to assess changes in prenatal testosterone levels. Plasma testosterone levels were measured in adults by a radioimmunoassay. The total frequency and time of socio-cohesive interactions were decreased in phthalate exposed females in weaning, puberty and adulthood. Phthalate exposed males showed a decrease in the frequency of social interactions in weaning only. Shorter anogenital distance was observed in adult males exposed to phthalates. Decreased testosterone levels were observed in the exposed group in both sexes. Our results suggest that early developmental phthalate exposure may play an important role in the hormonal and behavioral changes associated with several neurodevelopmental diseases.<\/jats:p>","DOI":"10.33549\/physiolres.934599","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T10:09:34Z","timestamp":1611742174000},"page":"S489-S498","source":"Crossref","is-referenced-by-count":9,"title":["A Mixture of Diethylhexyl, Diisononyl and Dibutyl Phthalate Decreased Anogenital Distance, Postnatal Testosterone Levels, and Changed Social Behavior in Wistar Rats"],"prefix":"10.33549","author":[{"given":"M","family":"MOROV\u00c1","sequence":"first","affiliation":[{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"SENKO","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"OLEXOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"DZIRB\u00cdKOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"KR\u0160KOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BARAKAT R, SEYMORE T, LIN PP, PARK CJ, KO CJ: Prenatal exposure to an environmentally relevant phthalate mixture disrupts testicular steroidogenesis in adult male mice. 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