{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:22:12Z","timestamp":1777328532667,"version":"3.51.4"},"reference-count":41,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Individual studies have suggested the utility of fractional exhaled nitric oxide (FeNO) measurement in detecting cough-variant asthma and eosinophilic bronchitis in patients with chronic cough. The aim of this study was to clarify a correlation of cough reflex sensitivity and fractional exhaled nitric oxide in asthmatic children. 25 children with asthma and 15 controls were submitted to cough reflex sensitivity measurement \u2013 capsaicin aerosol in doubling concentrations (from 0.61 to 1250 \u00b5mol\/l) was inhaled by a single breath method. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Fractional exhaled nitric oxide (FeNO) measurement was included. Asthmatic children (11 boys and 14 girls, mean age 9\u00b11 years) and control group (unconfirmed diagnosis of asthma) (6 boys and 9 girls, mean age 8\u00b11 years) were included into the study. FeNO vs. C2 in asthma (Spearman\u00b4s rank correlation: -0.146, p=0.49); FENO vs. C5 in asthma (Spearman\u00b4s rank correlation: -0.777, p=0.71). We found that there is no correlation between cough reflex sensitivity and fractional exhaled nitric oxide either in children with asthma or in the control group.<\/jats:p>","DOI":"10.33549\/physiolres.934601","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T14:06:21Z","timestamp":1611756381000},"page":"S455-S461","source":"Crossref","is-referenced-by-count":3,"title":["Cough Reflex Sensitivity and Fractional Exhaled Nitric Oxide in Children With Asthma"],"prefix":"10.33549","author":[{"given":"P","family":"KUNC","sequence":"first","affiliation":[{"name":"Clinic of Paediatric Respiratory Diseases and Tuberculosis, Jessenius Faculty of Medicine in Martin, National Institute of Paediatric Tuberculosis and Respiratory Diseases, Dolny Smokovec, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"FABRY","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Respiratory Diseases and Tuberculosis, Jessenius Faculty of Medicine in Martin, National Institute of Paediatric Tuberculosis and Respiratory Diseases, Dolny Smokovec, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"ZATKO","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"GRENDAR","sequence":"additional","affiliation":[{"name":"Biomedical Center, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"TATAR","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"PECOVA","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ALVING K, MALINOVSCHI A: Basic aspects of exhaled nitric oxide. 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