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At the end of the experiment, fish were sampled and the biometrical data were recorded. Subsequently, hematological and biochemical tests, histopathological examination, analysis of oxidative stress markers and evaluation of endocrine disruption using plasma vitellogenin were performed. In conclusion, an increase of hematocrit for both AHTN concentrations was found, but no significant changes were observed in biochemical profile. Moreover, AHTN caused lipid peroxidation in caudal kidney tissue, which was confirmed by histopathological images. The long-lasting AHTN exposure could thus be harmful for maintaining homeostasis in the rainbow trout organism. However, the vitellogenin concentration seemed not to be affected by AHTN.<\/jats:p>","DOI":"10.33549\/physiolres.934608","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:04:39Z","timestamp":1614596679000},"page":"S595-S606","source":"Crossref","is-referenced-by-count":14,"title":["Could the Musk Compound Tonalide Affect Physiological Functions and Act as an Endocrine Disruptor in Rainbow Trout?"],"prefix":"10.33549","author":[{"given":"N","family":"HODKOVICOVA","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Preventive Medicine, Veterinary Research Institute, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"ENEVOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"CAHOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"BLAHOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"SIROKA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"PLHALOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"DOUBKOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"MARSALEK","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"FRANC","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"FIORINO","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"FAGGIO","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"TICHY","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"FALDYNA","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Preventive Medicine, Veterinary Research Institute, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"SVOBODOVA","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref0","unstructured":"APHA: Standard Methods for the Examination of Water and Wastewater, 23rd. 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