{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:40:40Z","timestamp":1763037640769},"reference-count":105,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Acute and chronic hepatitis, cirrhosis, and other liver diseases pose a serious threat to human health; however, liver transplantation is the only reliable treatment for the terminal stage of liver diseases. Previous researchers have shown that mesenchymal stem cells (MSCs) are characterized by differentiation and paracrine effects, as well as anti-oxidative stress and immune regulation functions. When MSCs are transplanted into animals, they migrate to the injured liver tissue along with the circulation, to protect the liver and alleviate the injury through the paracrine, immune regulation and other characteristics, making mesenchymal stem cell transplantation a promising alternative therapy for liver diseases. Although the efficacy of MSCs transplantation has been confirmed in various animal models of liver injury, many researchers have also proposed various pretreatment methods to improve the efficacy of mesenchymal stem cell transplantation, but there is still lack a set of scientific methods system aimed at improving the efficacy of transplantation therapy in scientific research and clinical practice. In this review, we summarize the possible mechanisms of MSCs therapy and compare the existing methods of MSCs modification corresponding to the treatment mechanism, hoping to provide as a reference to help future researchers explore a safe and simple transplantation strategy.<\/jats:p>","DOI":"10.33549\/physiolres.934623","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T12:28:18Z","timestamp":1627475298000},"page":"327-343","source":"Crossref","is-referenced-by-count":4,"title":["Application of Modified Mesenchymal Stem Cells Transplantation in the Treatment of Liver Injury"],"prefix":"10.33549","author":[{"given":"L","family":"LIU","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Yangtze University Health Science Center, Jingzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"YANG","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Yangtze University Health Science Center, Jingzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AKIYAMA K, CHEN C, WANG D, XU X, QU C, YAMAZA T, CAI T, CHEN W, SUN L, SHI S: Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-\/FAS-mediated T cell apoptosis. Cell Stem Cell 10: 544-555, 2012. https:\/\/doi.org\/10.1016\/j.stem.2012.03.007","DOI":"10.1016\/j.stem.2012.03.007"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"AKYUREKLI C, LE Y, RICHARDSON RB, FERGUSSON D, TAY J, ALLAN DS: A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev Rep 11: 150-160, 2015. https:\/\/doi.org\/10.1007\/s12015-014-9545-9","DOI":"10.1007\/s12015-014-9545-9"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"AMABLE PR, TEIXEIRA MV, CARIAS RB, GRANJEIRO JM, BOROJEVIC R: Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton's jelly. Stem Cell Res Ther 5: 53, 2014. https:\/\/doi.org\/10.1186\/scrt442","DOI":"10.1186\/scrt442"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"ANGER F, CAMARA M, ELLINGER E, GERMER CT, SCHLEGEL N, OTTO C, KLEIN I: Human mesenchymal stromal cell-derived extracellular vesicles improve liver regeneration after ischemia reperfusion injury in mice. Stem Cells Dev 28: 1451-1462, 2019. https:\/\/doi.org\/10.1089\/scd.2019.0085","DOI":"10.1089\/scd.2019.0085"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"BAGLIO SR, PEGTEL DM, BALDINI N: Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 3: 359, 2012. https:\/\/doi.org\/10.3389\/fphys.2012.00359","DOI":"10.3389\/fphys.2012.00359"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"BAI L, LI D, LI J, LUO Z, YU S, CAO S, SHEN L, ZUO Z, MA X: Bioactive molecules derived from umbilical cord mesenchymal stem cells. Acta Histochem 118: 761-769, 2016. https:\/\/doi.org\/10.1016\/j.acthis.2016.09.006","DOI":"10.1016\/j.acthis.2016.09.006"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"BANAS A, TERATANI T, YAMAMOTO Y, TOKUHARA M, TAKESHITA F, OSAKI M, KATO T, OKOCHI H, OCHIYA T: Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol 24: 70-77, 2009. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05496.x","DOI":"10.1111\/j.1440-1746.2008.05496.x"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"BANAS A, TERATANI T, YAMAMOTO Y, TOKUHARA M, TAKESHITA F, OSAKI M, KAWAMATA M, KATO T, OKOCHI H, OCHIYA T: IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 26: 2705-2712, 2008. https:\/\/doi.org\/10.1634\/stemcells.2008-0034","DOI":"10.1634\/stemcells.2008-0034"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"BOELENS MC, WU TJ, NABET BY, XU B, QIU Y, YOON T, AZZAM DJ, TWYMAN-SAINT VICTOR C, WIEMANN BZ, ISHWARAN H, TER BRUGGE PJ, JONKERS J, SLINGERLAND J, MINN AJ: Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell 159: 499-513, 2014. https:\/\/doi.org\/10.1016\/j.cell.2014.09.051","DOI":"10.1016\/j.cell.2014.09.051"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"BOYD A, NEWSOME P, LU WY: The role of stem cells in liver injury and repair. Expert Rev Gastroenterol Hepatol 13: 623-631, 2019. https:\/\/doi.org\/10.1080\/17474124.2019.1618186","DOI":"10.1080\/17474124.2019.1618186"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"BRUCKNER S, ZIPPRICH A, HEMPEL M, THONIG A, SCHWILL F, RODERFELD M, ROEB E, CHRIST B: Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells. Cytotherapy 19: 1462-1473, 2017. https:\/\/doi.org\/10.1016\/j.jcyt.2017.09.006","DOI":"10.1016\/j.jcyt.2017.09.006"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"CASH WJ, MCCANCE DR, YOUNG IS, MCENENY J, CADDEN IS, MCDOUGALL NI, CALLENDER ME: Primary biliary cirrhosis is associated with oxidative stress and endothelial dysfunction but not increased cardiovascular risk. Hepatol Res 40: 1098-1106, 2010. https:\/\/doi.org\/10.1111\/j.1872-034X.2010.00717.x","DOI":"10.1111\/j.1872-034x.2010.00717.x"},{"key":"ref12","unstructured":"CHEN L, ZENG W, YANG B, CUI X, FENG C, WANG L, WANG H, ZHOU X, LI P, LV F, LI T: Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis. Am J Transl Res 9: 1500-1508, 2017."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"CHEN L, ZHANG C, CHEN L, WANG X, XIANG B, WU X, GUO Y, MOU X, YUAN L, CHEN B, WANG J, XIANG C: Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators. Stem Cells Transl Med 6: 272-284, 2017. https:\/\/doi.org\/10.5966\/sctm.2015-0265","DOI":"10.5966\/sctm.2015-0265"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"CHEN M, HUANG W, WANG C, NIE H, LI G, SUN T, YANG F, ZHANG Y, SHU K, WANG C, GONG Q: High-mobility group box 1 exacerbates CCl(4)-induced acute liver injury in mice. Clin Immunol 153: 56-63, 2014. https:\/\/doi.org\/10.1016\/j.clim.2014.03.021","DOI":"10.1016\/j.clim.2014.03.021"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"CHEN R, LEE WY, ZHANG XH, ZHANG JT, LIN S, XU LL, HUANG B, YANG FY, LIU HL, WANG B, TSANG LL, WILLAIME-MORAWEK S, LI G, CHAN HC, JIANG X: Epigenetic modification of the CCL5\/CCR1\/ERK axis enhances glioma targeting in dedifferentiation-reprogrammed BMSCs. Stem Cell Reports 8: 743-757, 2017. https:\/\/doi.org\/10.1016\/j.stemcr.2017.01.016","DOI":"10.1016\/j.stemcr.2017.01.016"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"CHEN Z, KUANG Q, LAO XJ, YANG J, HUANG W, ZHOU D: Differentiation of UC-MSCs into hepatocyte-like cells in partially hepatectomized model rats. Exp Ther Med 12: 1775-1779, 2016. https:\/\/doi.org\/10.3892\/etm.2016.3543","DOI":"10.3892\/etm.2016.3543"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"CHENG Y, CAO X, QIN L: Mesenchymal stem cell-derived extracellular vesicles: A novel cell-free therapy for sepsis. Front Immunol 11: 647, 2020. https:\/\/doi.org\/10.3389\/fimmu.2020.00647","DOI":"10.3389\/fimmu.2020.00647"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"CHO KA, WOO SY, SEOH JY, HAN HS, RYU KH: Mesenchymal stem cells restore CCl4-induced liver injury by an antioxidative process. Cell Biol Int 36: 1267-1274, 2012. https:\/\/doi.org\/10.1042\/CBI20110634","DOI":"10.1042\/cbi20110634"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"CHOI JS, JEONG IS, HAN JH, CHEON SH, KIM SW: IL-10-secreting human MSCs generated by TALEN gene editing ameliorate liver fibrosis through enhanced anti-fibrotic activity. Biomater Sci 7: 1078-1087, 2019. https:\/\/doi.org\/10.1039\/C8BM01347K","DOI":"10.1039\/c8bm01347k"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"DAI LJ, LI HY, GUAN LX, RITCHIE G, ZHOU JX: The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis. Stem Cell Res 2: 16-25, 2009. https:\/\/doi.org\/10.1016\/j.scr.2008.07.005","DOI":"10.1016\/j.scr.2008.07.005"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"DE LUNA-SALDIVAR MM, MARINO-MARTINEZ IA, FRANCO-MOLINA MA, RIVERA-MORALES LG, ALARCON-GALVAN G, CORDERO-PEREZ P, ROJAS-MARTINEZ A, RODRIGUEZ-PADILLA C, MUNOZ-ESPINOSA LE: Advantages of adipose tissue stem cells over CD34(+) mobilization to decrease hepatic fibrosis in Wistar rats. Ann Hepatol 18: 620-626, 2019. https:\/\/doi.org\/10.1016\/j.aohep.2018.12.005","DOI":"10.1016\/j.aohep.2018.12.005"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"DUMAN DG, ZIBANDEH N, UGURLU MU, CELIKEL C, AKKOC T, BANZRAGCH M, GENC D, OZDOGAN O, AKKOC T: Mesenchymal stem cells suppress hepatic fibrosis accompanied by expanded intrahepatic natural killer cells in rat fibrosis model. Mol Biol Rep 46: 2997-3008, 2019. https:\/\/doi.org\/10.1007\/s11033-019-04736-4","DOI":"10.1007\/s11033-019-04736-4"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"EL BAZ H, DEMERDASH Z, KAMEL M, HAMMAM O, SAMIR ABDELHADY D, MAHMOUD S, HASSAN S, MAHMOUD F, ATTA S, RIAD NM, GAAFAR T: Induction of hepatic regeneration in an experimental model using hepatocyte-differentiated mesenchymal stem cells. Cell Reprogram 22: 2020. https:\/\/doi.org\/10.1089\/cell.2019.0076","DOI":"10.1089\/cell.2019.0076"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"EOM YW, SHIM KY, BAIK SK: Mesenchymal stem cell therapy for liver fibrosis. Korean J Intern Med 30: 580-589, 2015. https:\/\/doi.org\/10.3904\/kjim.2015.30.5.580","DOI":"10.3904\/kjim.2015.30.5.580"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"FAROUK S, SABET S, ABU ZAHRA FA, EL-GHOR AA: Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6\/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. PLoS One 13: e0206130, 2018. https:\/\/doi.org\/10.1371\/journal.pone.0206130","DOI":"10.1371\/journal.pone.0206130"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"FATHI E, FARAHZADI R, SHEIKHZADEH N: Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. Tissue Cell 57: 15-21, 2019. https:\/\/doi.org\/10.1016\/j.tice.2019.01.006","DOI":"10.1016\/j.tice.2019.01.006"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"FIKRY H, GAWAD SA, BAHER W: Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver injury induced by Schistosoma mansoni: A histological study. Int J Stem Cells 9: 96-106, 2016. https:\/\/doi.org\/10.15283\/ijsc.2016.9.1.96","DOI":"10.15283\/ijsc.2016.9.1.96"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"FIORE E, DOMINGUEZ LM, BAYO J, MALVICINI M, ATORRASAGASTI C, RODRIGUEZ M, CANTERO MJ, GARCIA M, YANNARELLI G, MAZZOLINI G: Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice. Gene Ther 27: 62-73, 2020. https:\/\/doi.org\/10.1038\/s41434-019-0102-7","DOI":"10.1038\/s41434-019-0102-7"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"FRANCOIS S, MOUISEDDINE M, ALLENET-LEPAGE B, VOSWINKEL J, DOUAY L, BENDERITTER M, CHAPEL A: Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects. Biomed Res Int 2013: 151679, 2013. https:\/\/doi.org\/10.1155\/2013\/151679","DOI":"10.1155\/2013\/151679"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"GAZDIC M, ARSENIJEVIC A, MARKOVIC BS, VOLAREVIC A, DIMOVA I, DJONOV V, ARSENIJEVIC N, STOJKOVIC M, VOLAREVIC V: Mesenchymal stem cell-dependent modulation of liver diseases. Int J Biol Sci 13: 1109-1117, 2017. https:\/\/doi.org\/10.7150\/ijbs.20240","DOI":"10.7150\/ijbs.20240"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"GAZDIC M, MARKOVIC BS, ARSENIJEVIC A, JOVICIC N, ACOVIC A, HARRELL CR, FELLABAUM C, DJONOV V, ARSENIJEVIC N, LUKIC ML, VOLAREVIC V: Crosstalk between mesenchymal stem cells and T regulatory cells is crucially important for the attenuation of acute liver injury. Liver Transpl 24: 687-702, 2018. https:\/\/doi.org\/10.1002\/lt.25049","DOI":"10.1002\/lt.25049"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"GAZDIC M, SIMOVIC MARKOVIC B, VUCICEVIC L, NIKOLIC T, DJONOV V, ARSENIJEVIC N, TRAJKOVIC V, LUKIC ML, VOLAREVIC V: Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner. J Tissue Eng Regen Med 12: e1173-e1185, 2018. https:\/\/doi.org\/10.1002\/term.2452","DOI":"10.1002\/term.2452"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"GOULD SJ, RAPOSO G: As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles 2: 2013. https:\/\/doi.org\/10.3402\/jev.v2i0.20389","DOI":"10.3402\/jev.v2i0.20389"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"GU Y, DING X, HUANG J, XUE M, ZHANG J, WANG Q, YU H, WANG Y, ZHAO F, WANG H, JIN M, WU Y, ZHANG Y: The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells. Cell Death Dis 9: 459, 2018. https:\/\/doi.org\/10.1038\/s41419-018-0532-y","DOI":"10.1038\/s41419-018-0532-y"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"HAJINEJAD M, PASBAKHSH P, OMIDI A, MORTEZAEE K, NEKOONAM S, MAHMOUDI R, KASHANI IR: Resveratrol pretreatment enhanced homing of SDF-1alpha-preconditioned bone marrow-derived mesenchymal stem cells in a rat model of liver cirrhosis. J Cell Biochem 119: 2939-2950, 2018. https:\/\/doi.org\/10.1002\/jcb.26500","DOI":"10.1002\/jcb.26500"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"HAN HS, LEE H, YOU D, NGUYEN VQ, SONG DG, OH BH, SHIN S, CHOI JS, KIM JD, PAN CH, JO DG, CHO YW, CHOI KY, PARK JH: Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis. J Control Release 320: 328-336, 2020. https:\/\/doi.org\/10.1016\/j.jconrel.2020.01.042","DOI":"10.1016\/j.jconrel.2020.01.042"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"HSIEH JY, WANG HW, CHANG SJ, LIAO KH, LEE IH, LIN WS, WU CH, LIN WY, CHENG SM: Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis. PLoS One 8: e72604, 2013. https:\/\/doi.org\/10.1371\/journal.pone.0072604","DOI":"10.1371\/journal.pone.0072604"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"HU C, LI L: The immunoregulation of mesenchymal stem cells plays a critical role in improving the prognosis of liver transplantation. J Transl Med 17: 412, 2019. https:\/\/doi.org\/10.1186\/s12967-019-02167-0","DOI":"10.1186\/s12967-019-02167-0"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"HU C, WU Z, LI L: Mesenchymal stromal cells promote liver regeneration through regulation of immune cells. Int J Biol Sci 16: 893-903, 2020. https:\/\/doi.org\/10.7150\/ijbs.39725","DOI":"10.7150\/ijbs.39725"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"HU C, ZHAO L, DUAN J, LI L: Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis. J Cell Mol Med 23: 1657-1670, 2019. https:\/\/doi.org\/10.1111\/jcmm.14115","DOI":"10.1111\/jcmm.14115"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"HU C, ZHAO L, WU Z, LI L: Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury. Stem Cell Res Ther 11: 88, 2020. https:\/\/doi.org\/10.1186\/s13287-020-01596-9","DOI":"10.1186\/s13287-020-01596-9"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"HU L, HU J, ZHAO J, LIU J, OUYANG W, YANG C, GONG N, DU L, KHANAL A, CHEN L: Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells. Biomed Res Int 2013: 438243, 2013. https:\/\/doi.org\/10.1155\/2013\/438243","DOI":"10.1155\/2013\/438243"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"HUANG B, CHENG X, WANG H, HUANG W, LA GA HU Z, WANG D, ZHANG K, ZHANG H, XUE Z, DA Y, ZHANG N, HU Y, YAO Z, QIAO L, GAO F, ZHANG R: Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively. J Translat Med 14: 45, 2016. https:\/\/doi.org\/10.1186\/s12967-016-0792-1","DOI":"10.1186\/s12967-016-0792-1"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"JIANG W, TAN Y, CAI M, ZHAO T, MAO F, ZHANG X, XU W, YAN Z, QIAN H, YAN Y: Human umbilical cord MSC-derived exosomes suppress the development of CCl4-induced liver injury through antioxidant effect. Stem Cells Int 2018: 6079642, 2018. https:\/\/doi.org\/10.1155\/2018\/6079642","DOI":"10.1155\/2018\/6079642"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"JIAO Z, LIU X, MA Y, GE Y, ZHANG Q, LIU B, WANG H: Adipose-derived stem cells protect ischemia-reperfusion and partial hepatectomy by attenuating endoplasmic reticulum stress. Front Cell Dev Biol 8: 177, 2020. https:\/\/doi.org\/10.3389\/fcell.2020.00177","DOI":"10.3389\/fcell.2020.00177"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"JIN W, LIANG X, BROOKS A, FUTREGA K, LIU X, DORAN MR, SIMPSON MJ, ROBERTS MS, WANG H: Modelling of the SDF-1\/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem\/stromal cells in mice. PeerJ 6: e6072, 2018. https:\/\/doi.org\/10.7717\/peerj.6072","DOI":"10.7717\/peerj.6072"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"JUNG J, MOON JW, CHOI JH, LEE YW, PARK SH, KIM GJ: Epigenetic alterations of IL-6\/STAT3 signaling by placental stem cells promote hepatic regeneration in a rat model with CCl4-induced liver injury. Int J Stem Cells 8: 79-89, 2015. https:\/\/doi.org\/10.15283\/ijsc.2015.8.1.79","DOI":"10.15283\/ijsc.2015.8.1.79"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"KAMEL MM, BAZ HGE, DEMERDASH Z, HASSAN S, SALAH F, MANSOUR WA, HAMMAM O, ATTA S, BAYOUMI A, HASSAN M, MAHMOUD S: Cord blood-derived mesenchymal stem cells with hepatogenic differentiation potential ameliorate chronic liver affection in experimental models. Adv Clin Exp Med 27: 1329-1339, 2018. https:\/\/doi.org\/10.17219\/acem\/70430","DOI":"10.17219\/acem\/70430"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"KATSELIS C, APOSTOLOU K, FERETIS T, PAPANIKOLAOU IG, ZOGRAFOS GC, TOUTOUZAS K, PAPALOIS A: Role of stem cells transplantation in tissue regeneration after acute or chronic acetaminophen induced liver injury. J Inv Surg 29: 112-120, 2015. https:\/\/doi.org\/10.3109\/08941939.2015.1086040","DOI":"10.3109\/08941939.2015.1086040"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"KIM S, KIM H-S, LEE E, KIM HO: In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells. Int J Mol Med 27: 701-706, 2011. https:\/\/doi.org\/10.3892\/ijmm.2011.627","DOI":"10.3892\/ijmm.2011.627"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"KIM SM, KIM DS, JEONG CH, KIM DH, KIM JH, JEON HB, KWON SJ, JEUN SS, YANG YS, OH W, CHANG JW: CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas. Biochem Biophys Res Commun 407: 741-746, 2011. https:\/\/doi.org\/10.1016\/j.bbrc.2011.03.093","DOI":"10.1016\/j.bbrc.2011.03.093"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"KLADNICK\u00c1 I, \u010cED\u00cdKOV\u00c1 M, KRIPNEROV\u00c1 M, DVO\u0158\u00c1KOV\u00c1 J, KOHOUTOV\u00c1 M, T\u016eMA Z, M\u00dcLLEROV\u00c1 D, KUNCOV\u00c1 J: Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68 (Suppl 3): S287-S296, 2019. https:\/\/doi.org\/10.33549\/physiolres.934353","DOI":"10.33549\/physiolres.934353"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"KOJIMA Y, TSUCHIYA A, OGAWA M, NOJIRI S, TAKEUCHI S, WATANABE T, NAKAJIMA K, HARA Y, YAMASHITA J, KIKUTA J, TAKAMURA M, ISHII M, TERAI S: Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions. Regen Ther 11: 269-281, 2019. https:\/\/doi.org\/10.1016\/j.reth.2019.08.005","DOI":"10.1016\/j.reth.2019.08.005"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"LEE KD, KUO TK, WHANG-PENG J, CHUNG YF, LIN CT, CHOU SH, CHEN JR, CHEN YP, LEE OK: In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40: 1275-1284, 2004. https:\/\/doi.org\/10.1002\/hep.20469","DOI":"10.1002\/hep.20469"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"LELEK J, ZUBA-SURMA EK: Perspectives for future use of extracellular vesicles from umbilical cord- and adipose tissue-derived mesenchymal stem\/stromal cells in regenerative therapies-synthetic review. Int J Mol Sci 21: 799, 2020. https:\/\/doi.org\/10.3390\/ijms21030799","DOI":"10.3390\/ijms21030799"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"LIANG X, DING Y, ZHANG Y, TSE HF, LIAN Q: Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell Transplant 23: 1045-1059, 2014. https:\/\/doi.org\/10.3727\/096368913X667709","DOI":"10.3727\/096368913x667709"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"LIANG X, LI T, ZHOU Q, PI S, LI Y, CHEN X, WENG Z, LI H, ZHAO Y, WANG H, CHEN Y: Mesenchymal stem cells attenuate sepsis-induced liver injury via inhibiting M1 polarization of Kupffer cells. Mol Cell Biochem 452: 187-197, 2018. https:\/\/doi.org\/10.1007\/s11010-018-3424-7","DOI":"10.1007\/s11010-018-3424-7"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"LIU J, PAN G, LIANG T, HUANG P: HGF\/c-Met signaling mediated mesenchymal stem cell-induced liver recovery in intestinal ischemia reperfusion model. Int J Med Sci 11: 626-633, 2014. https:\/\/doi.org\/10.7150\/ijms.8228","DOI":"10.7150\/ijms.8228"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"LOU G, CHEN Z, ZHENG M, LIU Y: Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases. Exp Mol Med 49: e346, 2017. https:\/\/doi.org\/10.1038\/emm.2017.63","DOI":"10.1038\/emm.2017.63"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"LU C, FENG Y, SUN X, LI N, KUANG D, WANG W, TONG P, HAN Y, XIA X, DAI J: Tree shrew bone marrow-derived mesenchymal stem cells express CD81, OCLN, and miR-122, facilitating the entire hepatitis C virus life cycle. J Med Virol 92: 3465-3474, 2020. https:\/\/doi.org\/10.1002\/jmv.25710","DOI":"10.1002\/jmv.25710"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"LYSY PA, SMETS F, SIBILLE C, NAJIMI M, SOKAL EM: Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation. Hepatology 46: 1574-1585, 2007. https:\/\/doi.org\/10.1002\/hep.21839","DOI":"10.1002\/hep.21839"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"MARDPOUR S, HASSANI SN, MARDPOUR S, SAYAHPOUR F, VOSOUGH M, AIJ, AGHDAMI N, HAMIDIEH AA, BAHARVAND H: Extracellular vesicles derived from human embryonic stem cell-MSCs ameliorate cirrhosis in thioacetamide-induced chronic liver injury. J Cell Physiol 233: 9330-9344, 2018. https:\/\/doi.org\/10.1002\/jcp.26413","DOI":"10.1002\/jcp.26413"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"MIAO CM, JIANG XW, HE K, LI P Z, LIU ZJ, CAO D, OU ZB, GONG JP, LIU CA, CHENG Y: Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells. Immunol Lett 179: 102-113, 2016. https:\/\/doi.org\/10.1016\/j.imlet.2016.09.009","DOI":"10.1016\/j.imlet.2016.09.009"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"MIRANDA JP, FILIPE E, FERNANDES AS, ALMEIDA JM, MARTINS JP, DE LA FUENTE A, ABAL M, BARCIA RN, CRUZ P, CRUZ H, CASTRO M, SANTOS JM: The human umbilical cord tissue-derived MSC population UCX((R)) promotes early motogenic effects on keratinocytes and fibroblasts and G-CSF-mediated mobilization of BM-MSCs when transplanted in vivo. Cell Transplant 24: 865-877, 2015. https:\/\/doi.org\/10.3727\/096368913X676231","DOI":"10.3727\/096368913x676231"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"MOON SH, LEE CM, PARK S-H, JIN NAM M: Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats. Growth Factors 37: 105-119, 2019. https:\/\/doi.org\/10.1080\/08977194.2019.1652399","DOI":"10.1080\/08977194.2019.1652399"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"PAREKKADAN B, VAN POLL D, SUGANUMA K, CARTER EA, BERTHIAUME F, TILLES AW, YARMUSH ML: Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One 2: e941, 2007. https:\/\/doi.org\/10.1371\/journal.pone.0000941","DOI":"10.1371\/journal.pone.0000941"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"PARK SR, KIM HJ, YANG SR, PARK CH, LEE HY, HONG IS: A novel endogenous damage signal, glycyl tRNA synthetase, activates multiple beneficial functions of mesenchymal stem cells. Cell Death Differ 25: 2023-2036, 2018. https:\/\/doi.org\/10.1038\/s41418-018-0099-2","DOI":"10.1038\/s41418-018-0099-2"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"PUGLISI MA, TESORI V, LATTANZI W, PISCAGLIA AC, GASBARRINI GB, D'UGO DM, GASBARRINI A: Therapeutic implications of mesenchymal stem cells in liver injury. J Biomed Biotechnol 2011: 860578, 2011. https:\/\/doi.org\/10.1155\/2011\/860578","DOI":"10.1155\/2011\/860578"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"PYTL\u00cdK R, RENTSCH C, SOUKUP T, NOVOTN\u00dd L, RENTSCH B, KANDEROV\u00c1 V, RYCHTRMOCOV\u00c1 H, KALM\u00c1ROV\u00c1 M, STEHL\u00cdK D, TRN\u011aN\u00dd M, SLANA\u0158 O: Efficacy and safety of human mesenchymal stromal cells in healing of critical-size bone defects in immunodeficient rats. Physiol Res 66: 113-123, 2017. https:\/\/doi.org\/10.33549\/physiolres.933376","DOI":"10.33549\/physiolres.933376"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"QI X, NG KT-P, LIAN Q, LI CX, GENG W, LING CC, YEUNG WH, MA YY, LIU XB, LIU H, LIU J, YANG XX, LO CM, MAN K: Glutathione peroxidase 3 delivered by hiPSC-MSCs ameliorated hepatic IR injury via inhibition of hepatic senescence. Theranostics 8: 212-222, 2018. https:\/\/doi.org\/10.7150\/thno.21656","DOI":"10.7150\/thno.21656"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"QU M, CUI J, ZHU J, MA Y, YUAN X, SHI J, GUO D, LI C: Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury. Biochem Biophys Res Commun 466: 173-179, 2015. https:\/\/doi.org\/10.1016\/j.bbrc.2015.08.125","DOI":"10.1016\/j.bbrc.2015.08.125"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"RADWAN RR, MOHAMED HA: Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats. J Photochem Photobiol B 178: 447-456, 2018. https:\/\/doi.org\/10.1016\/j.jphotobiol.2017.11.037","DOI":"10.1016\/j.jphotobiol.2017.11.037"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"RAPOSO G, STOORVOGEL W: Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200: 373-383, 2013. https:\/\/doi.org\/10.1083\/jcb.201211138","DOI":"10.1083\/jcb.201211138"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"RUI Y, XU L, CHEN R, ZHANG T, LIN S, HOU Y, LIU Y, MENG F, LIU Z, NI M, TSANG KS, YANG F, WANG C, CHAN HC, JIANG X, LI G: Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Sci Rep 5: 11056, 2015. https:\/\/doi.org\/10.1038\/srep11056","DOI":"10.1038\/srep11056"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"RUSTAD KC, GURTNER GC: Mesenchymal stem cells home to sites of injury and inflammation. Adv Wound Care (New Rochelle) 1: 147-152, 2012. https:\/\/doi.org\/10.1089\/wound.2011.0314","DOI":"10.1089\/wound.2011.0314"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"SABRY D, MOHAMED A, MONIR M, IBRAHIM HA: The effect of mesenchymal stem cells derived microvesicles on the treatment of experimental CCL4 induced liver fibrosis in rats. Int J Stem Cells 12: 400-409, 2019. https:\/\/doi.org\/10.15283\/ijsc18143","DOI":"10.15283\/ijsc18143"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"SAMSONRAJ RM, RAI B, SATHIYANATHAN P, PUAN KJ, ROTZSCHKE O, HUI JH, RAGHUNATH M, STANTON LW, NURCOMBE V, COOL SM: Establishing criteria for human mesenchymal stem cell potency. Stem Cells 33: 1878-1891, 2015. https:\/\/doi.org\/10.1002\/stem.1982","DOI":"10.1002\/stem.1982"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"SATO Y, ARAKI H, KATO J, NAKAMURA K, KAWANO Y, KOBUNE M, SATO T, MIYANISHI K, TAKAYAMA T, TAKAHASHI M, TAKIMOTO R, IYAMA S, MATSUNAGA T, OHTANI S, MATSUURA A, HAMADA H, NIITSU Y: Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 106: 756-763, 2005. https:\/\/doi.org\/10.1182\/blood-2005-02-0572","DOI":"10.1182\/blood-2005-02-0572"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"SCHWARTZ RE, REYES M, KOODIE L, JIANG Y, BLACKSTAD M, LUND T, LENVIK T, JOHNSON S, HU W-S, VERFAILLIE CM: Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109: 1291-1302, 2002. https:\/\/doi.org\/10.1172\/JCI0215182","DOI":"10.1172\/jci0215182"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"SEO KW, SOHN SY, BHANG DH, NAM MJ, LEE HW, YOUN HY: Therapeutic effects of hepatocyte growth factor-overexpressing human umbilical cord blood-derived mesenchymal stem cells on liver fibrosis in rats. Cell Biol Int 38: 106-116, 2014. https:\/\/doi.org\/10.1002\/cbin.10186","DOI":"10.1002\/cbin.10186"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"SHAMS S, MOHSIN S, NASIR GA, KHAN M, KHAN SN: Mesenchymal stem cells pretreated with HGF and FGF4 can reduce liver fibrosis in mice. Stem Cells Int 2015: 747245, 2015. https:\/\/doi.org\/10.1155\/2015\/747245","DOI":"10.1155\/2015\/747245"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"SHARMA RR, POLLOCK K, HUBEL A, MCKENNA D: Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices. Transfusion 54: 1418-1437, 2014. https:\/\/doi.org\/10.1111\/trf.12421","DOI":"10.1111\/trf.12421"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"SHEN C, LIE P, MIAO T, YU M, LU Q, FENG T, LI J, ZU T, LIU X, LI H: Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis. Mol Med Rep 12: 20-30, 2015. https:\/\/doi.org\/10.3892\/mmr.2015.3409","DOI":"10.3892\/mmr.2015.3409"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"VALADI H, EKSTROM K, BOSSIOS A, SJOSTRAND M, LEE JJ, LOTVALL JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654-659, 2007. https:\/\/doi.org\/10.1038\/ncb1596","DOI":"10.1038\/ncb1596"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"VOLAREVIC V, AL-QAHTANI A, ARSENIJEVIC N, PAJOVIC S, LUKIC ML: Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity 43: 255-263, 2010. https:\/\/doi.org\/10.3109\/08916930903305641","DOI":"10.3109\/08916930903305641"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"VOLAREVIC V, ARSENIJEVIC N, LUKIC ML, STOJKOVIC M: Concise review: Mesenchymal stem cell treatment of the complications of diabetes mellitus. Stem Cells 29: 5-10, 2011. https:\/\/doi.org\/10.1002\/stem.556","DOI":"10.1002\/stem.556"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"VOLAREVIC V, NURKOVIC J, ARSENIJEVIC N, STOJKOVIC M: Concise review: Therapeutic potential of mesenchymal stem cells for the treatment of acute liver failure and cirrhosis. Stem Cells 32: 2818-2823, 2014. https:\/\/doi.org\/10.1002\/stem.1818","DOI":"10.1002\/stem.1818"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"WAN YM, LI ZQ, LIU C, HE YF, WANG MJ, WU XN, ZHANG Y, LI YH: Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress. PLoS One 15: e0228889, 2020. https:\/\/doi.org\/10.1371\/journal.pone.0228889","DOI":"10.1371\/journal.pone.0228889"},{"key":"ref89","doi-asserted-by":"publisher","unstructured":"WANG W, GUO H, LI H, YAN Y, WU C, WANG X, HE X, ZHAO N: Interleukin-35 gene-modified mesenchymal stem cells protect concanavalin A-induced fulminant hepatitis by decreasing the interferon gamma level. Hum Gene Ther 29: 234-241, 2018. https:\/\/doi.org\/10.1089\/hum.2017.171","DOI":"10.1089\/hum.2017.171"},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"XU LJ, WANG SF, WANG DQ, MA LJ, CHEN Z, CHEN QQ, WANG J, YAN L: Adipose-derived stromal cells resemble bone marrow stromal cells in hepatocyte differentiation potential in vitro and in vivo. World J Gastroenterol 23: 6973-6982, 2017. https:\/\/doi.org\/10.3748\/wjg.v23.i38.6973","DOI":"10.3748\/wjg.v23.i38.6973"},{"key":"ref91","doi-asserted-by":"publisher","unstructured":"XU T-B, LI L, LUO X-D, LIN H: BMSCs protect against liver injury via suppressing hepatocyte apoptosis and activating TGF-\u03b21\/Bax singling pathway. Biomed Pharmacother 96: 1395-1402, 2017. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.023","DOI":"10.1016\/j.biopha.2017.11.023"},{"key":"ref92","doi-asserted-by":"publisher","unstructured":"YAN Y, XU W, QIAN H, SI Y, ZHU W, CAO H, ZHOU H, MAO F: Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int 29: 356-365, 2009. https:\/\/doi.org\/10.1111\/j.1478-3231.2008.01855.x","DOI":"10.1111\/j.1478-3231.2008.01855.x"},{"key":"ref93","doi-asserted-by":"publisher","unstructured":"YANG B, DUAN W, WEI L, ZHAO Y, HAN Z, WANG J, WANG M, DAI C, ZHANG B, CHEN D, CHEN Z: Bone marrow mesenchymal stem cell-derived hepatocyte-like cell exosomes reduce hepatic ischemia\/reperfusion injury by enhancing autophagy. Stem Cells Dev 29: 372-379, 2020. https:\/\/doi.org\/10.1089\/scd.2019.0194","DOI":"10.1089\/scd.2019.0194"},{"key":"ref94","doi-asserted-by":"publisher","unstructured":"YANG FY, CHEN R, ZHANG X, HUANG B, TSANG LL, LI X, JIANG X: Preconditioning enhances the therapeutic effects of mesenchymal stem cells on colitis through PGE2-mediated T-cell modulation. Cell Transplant 27: 1352-1367, 2018. https:\/\/doi.org\/10.1177\/0963689718780304","DOI":"10.1177\/0963689718780304"},{"key":"ref95","doi-asserted-by":"publisher","unstructured":"YE Z, LU W, LIANG L, TANG M, WANG Y, LI Z, ZENG H, WANG A, LIN M, HUANG L, WANG H, HU H: Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice. Stem Cell Res Ther 10: 149, 2019. https:\/\/doi.org\/10.1186\/s13287-019-1260-7","DOI":"10.1186\/s13287-019-1260-7"},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"YU J, CAO H, YANG J, PAN Q, MA J, LI J, LI Y, LI J, WANG Y, LI L: In vivo hepatic differentiation of mesenchymal stem cells from human umbilical cord blood after transplantation into mice with liver injury. Biochem Biophys Res Commun 422: 539-545, 2012. https:\/\/doi.org\/10.1016\/j.bbrc.2012.04.156","DOI":"10.1016\/j.bbrc.2012.04.156"},{"key":"ref97","doi-asserted-by":"publisher","unstructured":"YU Y, YAO A H, CHEN N, PU LY, FAN Y, LV L, SUN BC, LI GQ, WANG XH: Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration. Mol Ther 15: 1382-1389, 2007. https:\/\/doi.org\/10.1038\/sj.mt.6300202","DOI":"10.1038\/sj.mt.6300202"},{"key":"ref98","doi-asserted-by":"publisher","unstructured":"YU YB, SONG Y, CHEN Y, ZHANG F, QI FZ: Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells. Mol Med Rep 18: 2009-2016, 2018. https:\/\/doi.org\/10.3892\/mmr.2018.9181","DOI":"10.3892\/mmr.2018.9181"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"ZHANG L, SONG Y, CHEN L, LI D, FENG H, LU Z, FAN T, CHEN Z, LIVINGSTON MJ, GENG Q: MiR-20a-containing exosomes from umbilical cord mesenchymal stem cells alleviates liver ischemia\/reperfusion injury. J Cell Physiol 235: 3698-3710, 2020. https:\/\/doi.org\/10.1002\/jcp.29264","DOI":"10.1002\/jcp.29264"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"ZHANG S, JIANG L, HU H, WANG H, WANG X, JIANG J, MA Y, YANG J, HOU Y, XIE D, ZHANG Q: Pretreatment of exosomes derived from hUCMSCs with TNF-alpha ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage. Life Sci 246: 117401, 2020. https:\/\/doi.org\/10.1016\/j.lfs.2020.117401","DOI":"10.1016\/j.lfs.2020.117401"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"ZHANG Y, CAI W, HUANG Q, GU Y, SHI Y, HUANG J, ZHAO F, LIU Q, WEI X, JIN M, WU C, XIE Q, ZHANG Y, WAN B, ZHANG Y: Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology 59: 671-682, 2014. https:\/\/doi.org\/10.1002\/hep.26670","DOI":"10.1002\/hep.26670"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"ZHENG J, CHEN L, LU T, ZHANG Y, SUI X, LI Y, HUANG X, HE L, CAI J, ZHOU C, LIANG J, CHEN G, YAO J, YANG Y: MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia\/reperfusion injury through AMPKalpha activation. Cell Death Dis 11: 256, 2020. https:\/\/doi.org\/10.1038\/s41419-020-2424-1","DOI":"10.1038\/s41419-020-2424-1"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"ZHENG J, LI H, HE L, HUANG Y, CAI J, CHEN L, ZHOU C, FU H, LU T, ZHANG Y, YAO J, YANG Y: Preconditioning of umbilical cord-derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia\/reperfusion injury in mice via the CXCR4\/CXCL12 axis. Cell Prolif 52: e12546, 2019. https:\/\/doi.org\/10.1111\/cpr.12546","DOI":"10.1111\/cpr.12546"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"ZHOU X, CUI L, ZHOU X, YANG Q, WANG L, GUO G, HOU Y, CAI W, HAN Z, SHI Y, HAN Y: Induction of hepatocyte-like cells from human umbilical cord-derived mesenchymal stem cells by defined microRNAs. J Cell Mol Med 21: 881-893, 2017. https:\/\/doi.org\/10.1111\/jcmm.13027","DOI":"10.1111\/jcmm.13027"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T12:28:30Z","timestamp":1627475310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/2021\/70_327.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":105,"URL":"https:\/\/doi.org\/10.33549\/physiolres.934623","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}