{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:47:09Z","timestamp":1751431629688},"reference-count":39,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Fatty acid (FA) profiles as potentially relevant components of Crohn\u2019s disease (CD) have been insufficiently analysed. We sought to explore the plasma profiles of n-3 and n-6 polyunsa-turated fatty acids (PUFAs) in newly diagnosed untreated active CD. We included 26 consecutive CD pediatric patients (&lt;19 years) and 14 healthy controls (HCs). Disease characteristics, including inflammatory markers, dietary histories, and the Pediatric Crohn\u2019s Disease Activity Index (PCDAI), were obtained. The profiles of plasma FAs in plasma lipid classes were analysed by gas chromatography with FID detection of methyl esters. The erythrocyte sedimentation rate, C-reactive protein level and fecal calprotectin level (all p&lt;0.001) were significantly higher in CD patients than in HCs. Most changes were observed in plasma phospholipids (PLs), such as a higher content of n-3 and changes in n-6 long-chain PUFAs in the CD group. The CD group had a lower ratio of n-6\/n-3 PUFAs in PLs (p&lt;0.001) and triacylglycerols (TAGs) (p&lt;0.01). Correlations of the FA content in plasma PLs with disease activity scores of CD were also observed, which were positive for the sum of monounsaturated fatty acids (MUFAs) as well as oleic acid (18:1n-9) (both p&lt;0.05). The metabolism of PUFAs is significantly altered even in treatment-na\u00efve newly diagnosed active pediatric CD, and the content of major FAs in PLs correlates with disease activity and inflammatory markers, thus probably contributing to the still unclear early disease pathogenesis.<\/jats:p>","DOI":"10.33549\/physiolres.934665","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T15:30:28Z","timestamp":1638977428000},"page":"799-808","source":"Crossref","is-referenced-by-count":4,"title":["The Assessment of Plasma Fatty Acid Profiles in Newly Diagnosed Treatment-Na\u00efve Paediatric Crohn\u2019s Disease"],"prefix":"10.33549","author":[{"given":"J","family":"SCHWARZ","sequence":"first","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"VECKA","sequence":"additional","affiliation":[{"name":"Fourth Department of Medicine, First Faculty of Medicine, Charles University, General University Hospital and Institute of Clinical Chemistry and Laboratory Diagnostics, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"STO\u017dICK\u00dd","sequence":"additional","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"POMAHA\u010cOV\u00c1","sequence":"additional","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"STA\u0147KOV\u00c1","sequence":"additional","affiliation":[{"name":"Fourth Department of Medicine, First Faculty of Medicine, Charles University, General University Hospital and Institute of Clinical Chemistry and Laboratory Diagnostics, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"TVRZICK\u00c1","sequence":"additional","affiliation":[{"name":"Fourth Department of Medicine, First Faculty of Medicine, Charles University, General University Hospital and Institute of Clinical Chemistry and Laboratory Diagnostics, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"KRESLOV\u00c1","sequence":"additional","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"ZAH\u00c1LKOV\u00c1","sequence":"additional","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"S\u00ddKORA","sequence":"additional","affiliation":[{"name":"Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Paediatrics, Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"CHILTON FH, DUTTA R, REYNOLDS LM, SERGEANT S, MATHIAS RA, SEEDS MC: Precision nutrition and omega-3 polyunsaturated fatty acids: A case for personalized supplementation approaches for the prevention and management of human diseases. 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