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The study included 10 rats in the control group (CONT) and 10 in the HBOT group, who underwent HBOT in standard clinical regimen. Histological evaluation was performed on the 18th day after induction of defect. The results show that HBOT did not affect the macroscopic size of the defect nor IL6 plasma levels. A volume fraction of type I collagen was slightly increased by HBOT without reaching statistical significance (1.35\u00b10.49 and 1.94\u00b10.67 %, CONT and HBOT, respectively). In contrast, the collagen type III volume fraction was ~120 % higher in HBOT wounds (1.41\u00b10.81 %) than in CONT ones (0.63\u00b10.37 %; p=0.046). In addition, the ratio of the volume fraction of both collagens in the wound ((I+III)w) to the volume fraction of both collagens in the adjacent healthy skin ((I+III)h) was ~65 % higher in rats subjected to HBOT (8.9\u00b13.07 vs. 5.38\u00b11.86 %, HBOT and CONT, respectively; p=0.028). Vessels density (number per 1 mm2) was found to be higher in CONT vs. HBOT (206.5\u00b141.8 and 124\u00b128.2, respectively, p&lt;0.001). Our study suggests that HBOT promotes collagen III formation and decreases the number of newly formed vessels at the early phases of healing.<\/jats:p>","DOI":"10.33549\/physiolres.934684","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T14:45:33Z","timestamp":1638974733000},"page":"787-798","source":"Crossref","is-referenced-by-count":4,"title":["Hyperbaric Oxygen Enhances Collagen III Formation in Wound of ZDF Rat"],"prefix":"10.33549","author":[{"given":"J","family":"R\u016e\u017dI\u010cKA","sequence":"first","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"GRAJCIAROV\u00c1","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"VI\u0160TEJNOV\u00c1","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"KLEIN","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"TICH\u00c1NEK","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"TONAR","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"DEJMEK","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"BENE\u0160","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"BOLEK","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"BAJGAR","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"KUNCOV\u00c1","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ANDR\u00c9-L\u00c9VIGNE D, MODARRESSI A, PIGNEL R, BOCHATON-PIALLAT ML, PITTET-CU\u00c9NOD B: Hyperbaric oxygen therapy promotes wound repair in ischemic and hyperglycemic conditions, increasing tissue perfusion and collagen deposition. 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