{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:27:30Z","timestamp":1780939650280,"version":"3.54.1"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular diseases, including insulin resistance, diabetes mellitus type 2, obesity, hypertension, and dyslipidaemia. Many studies have assessed the role of adipokines in the etiopathogenesis of PCOS, however, no single biomarker has been recognized to be in causal relation to the syndrome. Apelin has been identified as a new adipokine linked to obesity and insulin resistance. Some studies demonstrated that the apelin \/ apelin receptor could play a pivotal role in the pathogenesis of polycystic ovary syndrome, however the other yielded controversial results. Underlying mechanisms of possible involvement of apelin\/apelin receptor complex are discussed.<\/jats:p>","DOI":"10.33549\/physiolres.934708","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T12:37:16Z","timestamp":1646656636000},"page":"S635-S641","source":"Crossref","is-referenced-by-count":6,"title":["Is Apelin a new biomarker in patients with polycystic ovary syndrome?"],"prefix":"10.33549","author":[{"given":"I","family":"Draveck\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Figurov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Laz\u00farov\u00e1","sequence":"additional","affiliation":[{"name":"1st Dept. Internal Med., Med. Fac. P. J. \u0160afarik Univ., Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2021,12,30]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T12:37:17Z","timestamp":1646656637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/2021\/70_S635.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.934708","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}