{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:03:01Z","timestamp":1790629381374,"version":"4.1.0"},"reference-count":57,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Tribulus terrestris, L. (puncture vine) have been used as a folk medicine for five thousands of years, but its targets, effects, their mechanisms and application requires further studies. This paper reviews the provenance, constituents and properties of Tribulus terrestris, L., its general physiological and health effects, as well as the currently available knowledge concerning its influence on male and female reproductive processes and their dysfunctions. Analysis of the available publications demonstrated the influence of Tribulus terrestris on a wide spectrum of targets and physiological processe and disorders. In particular, Tribulus terrestris can be a stimulator of male and female reproductive processes at the level of central nervous system, sexual behaviour, pituitary and gonadal hormones and their receptors, gonadal functions (including ovarian follicullogenesis and spermatogenesis), improvement of the quality and quantity of gametes (at least of sperm) and fecundity. This ability of puncture vine is applicable for the improvement of man\u2019s sexual desire and sperm quality in vivo and in vitro, as well as of women\u2019s libido, activation of women\u2019s reproductive organs, fecundity, and treatment of infertility, especially that related to the polycystic ovarian syndrome.<\/jats:p>","DOI":"10.33549\/physiolres.934711","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T10:35:45Z","timestamp":1646735745000},"page":"S657-S667","source":"Crossref","is-referenced-by-count":15,"title":["Puncture vine (Tribulus Terrestris L.) in control of health and reproduction"],"prefix":"10.33549","author":[{"given":"AV","family":"Sirotkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Koles\u00e1rov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ABADJIEVA D, KISTANOVA E: Tribulus terrestris alters the expression of growth differentiation factor 9 and bone morphogenetic protein 15 in rabbit ovaries of mothers and f1 female offspring. 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