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Activated HSCs significantly contribute to liver fibrosis progression and inactivated HSCs are key to liver fibrosis regression. In this review, we summarize the comprehensive understanding of HSCs features, including their roles in normal liver and liver fibrosis in hopes of advancing the development of emerging diagnosis and treatment for hepatic fibrosis.<\/jats:p>","DOI":"10.33549\/physiolres.934755","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T14:07:22Z","timestamp":1640182042000},"page":"821-829","source":"Crossref","is-referenced-by-count":57,"title":["Hepatic Stellate Cell: A Double-Edged Sword in the Liver"],"prefix":"10.33549","author":[{"given":"N.","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dong","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China. dongrui2020@yeah.net"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ARAB JP, CABRERA D, SEHRAWAT TS, JALAN-SAKRIKAR N, VERMA VK, SIMONETTO D, CAO S, YAQOOB U, LEON J, FREIRE M, VARGAS JI, DE ASSUNCAO TM, KWON JH, GUO Y, KOSTALLARI E, CAI Q, KISSELEVA T, OH Y, ARRESE M, HUEBERT RC, SHAH VH: Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12, J Hepatol 73: 149-160, 2020. https:\/\/doi:10.1016\/j.jhep.2020.02.005","DOI":"10.1016\/j.jhep.2020.02.005"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"ARRIOLA BENITEZ PC, PESCE VIGLIETTI AI, GOMES MTR, OLIVEIRA SC, QUARLERI JF, GIAMBARTOLOMEI GH, DELPINO MV: Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1beta Production, Front Immunol 10: 3036, 2019. https:\/\/doi:10.3389\/fimmu.2019.03036","DOI":"10.3389\/fimmu.2019.03036"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BANSAL MB: Hepatic stellate cells: fibrogenic, regenerative or both? 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