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In alphabetic order are examined arginine, \u03b2-alanine, branched-chain amino acids, carnosine, citrulline, creatine, glutamine, histidine, \u03b2-hydroxy-\u03b2-methylbutyrate, leucine, and tryptophan. In the article is shown that enhanced intake of most amino acid supplements may not be risk-free and can cause a number of detrimental side effects. Further research is necessary to elucidate effects of high doses and long-term consumption of amino acid supplements on immune system, brain function, muscle protein balance, synthesis of toxic metabolites, and tumor growth and examine their suitability under certain circumstances. These include elderly, childhood, pregnancy, nursing a baby, and medical condition, such as diabetes and liver disease. Studies are also needed to examine adaptive response to a long-term intake of any substance and consequences of discontinuation of supplementation.<\/jats:p>","DOI":"10.33549\/physiolres.934790","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T13:34:38Z","timestamp":1648215278000},"page":"29-45","source":"Crossref","is-referenced-by-count":62,"title":["Side Effects of Amino Acid Supplements"],"prefix":"10.33549","author":[{"given":"M","family":"HOLE\u010cEK","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Fabresse N, Gheddar L, Kintz P, Knapp A, Larabi IA, Alvarez JC. 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