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The Radio Electric Asymmetric Conveyer (REAC) technology, aimed at reorganizing the endogenous bioelectric activity, has already shown to be able to determine direct cell reprogramming effects and counteract the senescence mechanisms in stem cells. Aim of the present study was to prove if the anti-senescence results previously obtained in different kind of stem cells with the REAC Tissue optimization \u2013 regenerative (TO-RGN) treatment, could also be observed in BMSCs, evaluating cell viability, telomerase activity, p19ARF, P21, P53, and hTERT gene expression. The results show that the REAC TO-RGN treatment may be a useful tool to counteract the BMSCs senescence which can be the basis of AML drift. Nevertheless, further clinical studies on humans are needed to confirm this hypothesis.<\/jats:p>","DOI":"10.33549\/physiolres.934903","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:43:44Z","timestamp":1663238624000},"page":"539-549","source":"Crossref","is-referenced-by-count":11,"title":["Antisenescence Effect of REAC Biomodulation to Counteract the Evolution of Myelodysplastic Syndrome"],"prefix":"10.33549","volume":"71","author":[{"given":"M","family":"Maioli","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43\/B, 07100 Sassari (SS) Italy. 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