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The cardiac function, myocardial fibrosis, apoptosis, oxidative stress, and inflammatory responses were determined by using pressure transducer catheter, polygraph physiological data acquisition system, Masson's trichrome staining, and ELISA to evaluate the impact of post-MI exercise training on MI. Western blot were performed to detect the activation of AMPK\/SIRT1\/PGC-1\u03b1 signaling in the hearts of aged rats. Exercise training significantly improved cardiac function and reduced the cardiac fibrosis. In infarcted heart, the apoptosis, oxidative stress, and inflammation were significantly reduced after 4-week exercise training. Mechanistically, AMPK\/SIRT1\/PGC-1\u03b1 pathway was activated in the myocardial infarction area after exercise training, which might participate in the protection of cardiac function. Exercise training improves cardiac function in MI rats through reduction of apoptosis, oxidative stress, and inflammation, which may mediate by the activation of AMPK\/SIRT1\/PGC-1\u03b1 signaling pathway.<\/jats:p>","DOI":"10.33549\/physiolres.934966","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:57:59Z","timestamp":1679306279000},"page":"27-35","source":"Crossref","is-referenced-by-count":11,"title":["Exercise Improves Cardiac Function in the Aged Rats With Myocardial Infarction"],"prefix":"10.33549","volume":"72","author":[{"given":"Y","family":"CHEN","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, The Affiliated Wuxi No. 2 People\u2019s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"HUANG","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Wuxi No. 2 People\u2019s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"FENG","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Wuxi No. 2 People\u2019s Hospital of Nanjing Medical University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tChakhtoura Z, Canonico M, Gompel A, Scarabin PY, Plu-Bureau G. 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