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A nematode Caenorhabditis elegans has become a useful alternative to animal models mainly because of its transparent body, fast growth, short life cycle, and easy cultivation. Furthermore, at the molecular level, there are significant similarities between humans and C. elegans. These unique features make it an excellent model to complement mammalian models in toxicology research. Heavy metals and pesticides, which are considered environmental contaminants, are known to have affected the locomotion, feeding behavior, brood size, growth, life span, and cell death of C. elegans. Today, there are increasing numbers of research articles dedicated to this topic, of which we summarized the most recent findings dedicated to the effect of heavy metals, heavy metal mixtures, and pesticides on the well\u2013characterized nervous system of this nematode.<\/jats:p>","DOI":"10.33549\/physiolres.934977","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T13:06:24Z","timestamp":1683032784000},"page":"149-166","source":"Crossref","is-referenced-by-count":20,"title":["Applications of a powerful model organism Caenorhabditis elegans to study the neurotoxicity induced by heavy metals and pesticides"],"prefix":"10.33549","author":[{"given":"K","family":"Melnikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kuchar\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Health Care and Social Work, University in Trnava, Slovakia. sona.kucharikova@truni.sk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"B\u00e1rdyov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Botek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kaiglov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Brenner S. 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