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We review the reproductive mechanisms responsible for ensuring a healthy mitochondrial population within each new generation and elucidate how advanced maternal age can constitute an increased risk for the onset of NDD in the offspring, through the increased heteroplasmic burden. On the one hand, this review draws attention to how assisted reproductive technologies (ART) can impair mitochondrial fitness in offspring. On the other hand, we consider qualified ART approaches as a significant tool for the prevention of NDD pathogenesis.<\/jats:p>","DOI":"10.33549\/physiolres.934982","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T12:54:16Z","timestamp":1683032056000},"page":"137-148","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondria in human reproduction: novel paradigm in the onset of neurodegenerative disorders"],"prefix":"10.33549","author":[{"given":"M","family":"Shavit","sequence":"first","affiliation":[{"name":"Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. miki.shavit@lfp.cuni.cz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Iniesta-Cuerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nevoral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Roger AJ, Mu\u00f1oz-G\u00f3mez SA, Kamikawa R. 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