{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:15:16Z","timestamp":1792635316898,"version":"4.5.0"},"reference-count":52,"publisher":"Institute of Physiology of the Czech Academy of Sciences","issue":"Suppl. 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>Mitochondria are considered central regulator of the aging process; however, majority of studies dealing with the impact of age on mitochondrial oxygen consumption focused on skeletal muscle concluding (although not uniformly) a general declining trend with advancing age. In addition, gender related differences in mitochondrial respiration have not been satisfactorily described yet. The aim of the present study was to evaluate mitochondrial oxygen consumption in various organs of aging male and female Fischer 344 rats at the ages of 6, 12 and 24 months. Mitochondrial respiration of homogenized (skeletal muscle, left and right heart ventricle, hippocampus, cerebellum, kidney cortex), gently mechanically permeabilized (liver) tissue or intact cells (platelets) was determined using high-resolution respirometry (oxygraphs O2k, Oroboros, Austria). The pattern of age-related changes differed in each tissue: in the skeletal muscle and kidney cortex of both sexes and in female heart, parameters of mitochondrial respiration significantly declined with age. Resting respiration of intact platelets displayed an increasing trend and it did not correlate with skeletal muscle respiratory states. In the heart of male rats and brain tissues of both sexes, respiratory states remained relatively stable over analyzed age categories with few exceptions of lower mitochondrial oxygen consumption at the age of 24 months. In the liver, OXPHOS capacity was higher in females than in males with either no difference between the ages of 6 and 24 months or even significant increase at the age of 24 months in the male rats. In conclusion, the results of our study indicate that the concept of general pattern of age-dependent decline in mitochondrial oxygen consumption across different organs and tissues could be misleading. Also, the statement of higher mitochondrial respiration in females seems to be conflicting, since the gender-related differences may vary with the tissue studied, combination of substrates used and might be better detectable at younger ages than in old animals.<\/jats:p>","DOI":"10.33549\/physiolres.934995","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:36:14Z","timestamp":1674552974000},"page":"S227-S236","source":"Crossref","is-referenced-by-count":26,"title":["Impact of Aging on Mitochondrial Respiration in Various Organs"],"prefix":"10.33549","volume":"71","author":[{"given":"J","family":"JEDLI\u010cKA","sequence":"first","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"T\u016eMA","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"RAZAK","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"KUNC","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"KALA","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"PROSKAUER PE\u00d1A","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"LERCHNER","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"JE\u017dEK","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"KUNCOV\u00c1","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.\tAnton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, ET AL. Successful aging: Advancing the science of physical independence in older adults. Ageing Res Rev 2015;24:304-327. https:\/\/doi.org\/10.1016\/j.arr.2015.09.005","DOI":"10.1016\/j.arr.2015.09.005"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.\tJang JY, Blum A, Liu J, Finkel T. The role of mitochondria in aging. J Clin Invest 2018;128:3662-3670. https:\/\/doi.org\/10.1172\/JCI120842","DOI":"10.1172\/jci120842"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.\tSon JM, Lee C. Mitochondria: multifaceted regulators of aging. BMB Rep 2019;52:13-23. https:\/\/doi.org\/10.5483\/BMBRep.2019.52.1.300","DOI":"10.5483\/bmbrep.2019.52.1.300"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4.\tSon JM, Lee C. Aging: All roads lead to mitochondria. Semin Cell Dev Biol 2021;116:160-168. https:\/\/doi.org\/10.1016\/j.semcdb.2021.02.006","DOI":"10.1016\/j.semcdb.2021.02.006"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"5.\tWeber TA, Reichert AS. Impaired quality control of mitochondria: aging from a new perspective. Exp Gerontol 2010;45:503-511. https:\/\/doi.org\/10.1016\/j.exger.2010.03.018","DOI":"10.1016\/j.exger.2010.03.018"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.\tZhou KI, Pincus Z, Slack FJ. Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) 2011;3:733-753. https:\/\/doi.org\/10.18632\/aging.100367","DOI":"10.18632\/aging.100367"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7.\tChabi B, Ljubicic V, Menzies KJ, Huang JH, Saleem A, Hood DA. Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell 2008;7:2-12. https:\/\/doi.org\/10.1111\/j.1474-9726.2007.00347.x","DOI":"10.1111\/j.1474-9726.2007.00347.x"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.\tMartin C, Dubouchaud H, Mosoni L, Chardigny JM, Oudot A, Fontaine E, Vergely C, ET AL. Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius. Aging Cell 2007;6:165-177. https:\/\/doi.org\/10.1111\/j.1474-9726.2007.00271.x","DOI":"10.1111\/j.1474-9726.2007.00271.x"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.\tDistefano G, Standley RA, Dub\u00e9 JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM. Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 2017;72:535-542. https:\/\/doi.org\/10.1093\/gerona\/glw102","DOI":"10.1093\/gerona\/glw102"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.\tVentura B, Genova ML, Bovina C, Formiggini G, Lenaz G. Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging. Biochim Biophys Acta 2002;1553:249-260. https:\/\/doi.org\/10.1016\/S0005-2728(01)00246-8","DOI":"10.1016\/s0005-2728(01)00246-8"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.\tNavarro A, Boveris A. Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J Physiol Regul Integr Comp Physiol 2004;287:1244-1249. https:\/\/doi.org\/10.1152\/ajpregu.00226.2004","DOI":"10.1152\/ajpregu.00226.2004"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.\tPokkunuri I, Ali Q, Asghar M. Grape powder improves age-related decline in mitochondrial and kidney functions in Fischer 344 rats. Oxid Med Cell Longev 2016;2016:6135319. https:\/\/doi.org\/10.1155\/2016\/6135319","DOI":"10.1155\/2016\/6135319"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13.\tKwong LK, Sohal RS. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Arch Biochem Biophys 2000;373:16-22. https:\/\/doi.org\/10.1006\/abbi.1999.1495","DOI":"10.1006\/abbi.1999.1495"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.\tPetrus AT, Lighezan DL, Danila MD, Duicu OM, Sturza A, Muntean DM, Ionita I. Assessment of platelet respiration as emerging biomarker of disease. Physiol Res 2019;68:347-363. https:\/\/doi.org\/10.33549\/physiolres.934032","DOI":"10.33549\/physiolres.934032"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.\tJedli\u010dka J, Kunc R, Kuncov\u00e1 J. Mitochondrial respiration of human platelets in young adult and advanced age - Seahorse or O2k? Physiol Res 2021;70:369-379. https:\/\/doi.org\/10.33549\/\/physiolres.934812","DOI":"10.33549\/\/physiolres.934812"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.\tLenaz G, Bovina C, Castelluccio C, Fato R, Formiggini G, Genova ML, Marchetti M, Pich MM, Pallotti F, Parenti Castelli G, Biagini G. Mitochondrial complex I defects in aging. Mol Cell Biochem 1997;174:329-333. https:\/\/doi.org\/10.1023\/A:1006854619336","DOI":"10.1007\/978-1-4615-6111-8_50"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.\tPesta D, Gnaiger E. High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 2012;810:25-58. https:\/\/doi.org\/10.1007\/978-1-61779-382-0_3","DOI":"10.1007\/978-1-61779-382-0_3"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.\tBraganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S. Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 2019;5:e128248. https:\/\/doi.org\/10.1172\/jci.insight.128248","DOI":"10.1172\/jci.insight.128248"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.\tTyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 2016;10:65-77. https:\/\/doi.org\/10.1016\/j.redox.2016.09.009","DOI":"10.1016\/j.redox.2016.09.009"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.\tWu YS, Liang S, Li DY, Wen JH, Tang JX, Liu HF. Cell cycle dysregulation and renal fibrosis. Front Cell Dev Biol 2021;9:714320. https:\/\/doi.org\/10.3389\/fcell.2021.714320","DOI":"10.3389\/fcell.2021.714320"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21.\tHolmes DJ. F344 Rat. Sci Aging Knowl Env 2003;36:as2-as2. https:\/\/doi.org\/10.1126\/sageke.2003.36.as2","DOI":"10.1126\/sageke.2003.36.as2"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.\tColom B, Alcolea MP, Valle A, Oliver J, Roca P, Garc\u00eda-Palmer FJ. Skeletal muscle of female rats exhibit higher mitochondrial mass and oxidative-phosphorylative capacities compared to males. Cell Physiol Biochem 2007;19:205-212. https:\/\/doi.org\/10.1159\/000099208","DOI":"10.1159\/000099208"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.\tFarhat F, Am\u00e9rand A, Simon B, Guegueniat N, Moisan C. Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training. Redox Rep 2017;22:508-514. https:\/\/doi.org\/10.1080\/13510002.2017.1296637","DOI":"10.1080\/13510002.2017.1296637"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.\tG\u00f3mez-P\u00e9rez Y, Amengual-Cladera E, Catal\u00e0-Niell A, Thom\u00e0s-Moy\u00e0 E, Gianotti M, Proenza AM, Llad\u00f3 I. Gender dimorphism in high-fat-diet-induced insulin resistance in skeletal muscle of aged rats. Cell Physiol Biochem 2008;22:539-548. https:\/\/doi.org\/10.1159\/000185538","DOI":"10.1159\/000185538"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.\tHepple RT. Mitochondrial involvement and impact in aging skeletal muscle. Front Aging Neurosci 2014;6:211. https:\/\/doi.org\/10.3389\/fnagi.2014.00211","DOI":"10.3389\/fnagi.2014.00211"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26.\tPicard M, Ritchie D, Thomas MM, Wright KJ, Hepple RT. Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles. Aging Cell 2011;10:1047-1055. https:\/\/doi.org\/10.1111\/j.1474-9726.2011.00745.x","DOI":"10.1111\/j.1474-9726.2011.00745.x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27.\tCrescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S. Skeletal muscle mitochondrial energetic efficiency and aging. Int J Mol Sci 2015;16:10674-10685. https:\/\/doi.org\/10.3390\/ijms160510674","DOI":"10.3390\/ijms160510674"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.\tLarsen RG, Callahan DM, Foulis SA, Kent-Braun JA. Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior. Appl Physiol Nutr Metab 2012;37:88-99. https:\/\/doi.org\/10.1139\/h11-135","DOI":"10.1139\/h11-135"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.\tEsselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP. A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 2021;23:140-160. https:\/\/doi.org\/10.1007\/s12017-020-08639-7","DOI":"10.1007\/s12017-020-08639-7"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30.\tBrierly EJ, Johnson MA, Bowman A, Ford GA, Subhan F, Reed JW, James OF, Turnbull DM. Mitochondrial function in muscle from elderly athletes. Ann Neurol 1997;41:114-116. https:\/\/doi.org\/10.1002\/ana.410410120","DOI":"10.1002\/ana.410410120"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.\tJunker A, Wang J, Gouspillou G, Ehinger JK, Elm\u00e9r E, Sj\u00f6vall F, Fisher-Wellman KH, Neufer PD, Molina AJA, Ferrucci L, Picard M. Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis. FASEB J 2022;36:e22146. https:\/\/doi.org\/10.1096\/fj.202101628R","DOI":"10.1101\/2021.11.03.21265871"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32.\tLalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR. Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 2017;9:1096-1129. https:\/\/doi.org\/10.18632\/aging.101210","DOI":"10.18632\/aging.101210"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33.\tFi\u0161ar Z, Hroudov\u00e1 J, Hans\u00edkov\u00e1 H, Sp\u00e1\u010dilov\u00e1 J, Lelkov\u00e1 P, Wenchich L, Jir\u00e1k R, Zv\u011b\u0159ov\u00e1 M, Zeman J, Mart\u00e1sek P, Raboch J. Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease. Curr Alzheimer Res 2016;13:930-941. https:\/\/doi.org\/10.2174\/1567205013666160314150856","DOI":"10.2174\/1567205013666160314150856"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.\tHedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL. Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J Appl Physiol (1985) 2019;126:454-461. https:\/\/doi.org\/10.1152\/japplphysiol.00777.2018","DOI":"10.1152\/japplphysiol.00777.2018"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35.\tRose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, B\u00f8rsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 2019;317:503-512. https:\/\/doi.org\/10.1152\/ajpendo.00084.2019","DOI":"10.1152\/ajpendo.00084.2019"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36.\tSj\u00f6vall F, Morota S, Hansson MJ, Friberg H, Gnaiger E, Elm\u00e9r E. Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 2010;14:214. https:\/\/doi.org\/10.1186\/cc9337","DOI":"10.1186\/cc9337"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37.\tEhinger JK, Morota S, Hansson MJ, Paul G, Elm\u00e9r E. Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 2015;262:1493-1503. https:\/\/doi.org\/10.1007\/s00415-015-7737-0","DOI":"10.1007\/s00415-015-7737-0"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38.\tNo MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB. Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 2020;472:179-193. https:\/\/doi.org\/10.1007\/s00424-020-02357-6","DOI":"10.1007\/s00424-020-02357-6"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"39.\tKhalifa AR, Abdel-Rahman EA, Mahmoud AM, Ali MH, Noureldin M, Saber SH, Mohsen M, Ali SS. Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 2017;5:e13125. https:\/\/doi.org\/10.14814\/phy2.13125","DOI":"10.14814\/phy2.13125"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"40.\tSanz A, Hiona A, Kujoth GC, Seo AY, Hofer T, Kouwenhoven E, Kalani R, Prolla TA, Barja G, Leeuwenburgh C. Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice. Exp Gerontol 2007;42:173-182. https:\/\/doi.org\/10.1016\/j.exger.2006.10.003","DOI":"10.1016\/j.exger.2006.10.003"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41.\t\u0160v\u00edglerov\u00e1 J, Kuncov\u00e1 J, Nalos L, Holas J, Tonar Z, Rajdl D, Stengl M. Cardiac remodeling in rats with renal failure shows interventricular differences. Exp Biol Med (Maywood) 2012;237:1056-1067. https:\/\/doi.org\/10.1258\/ebm.2012.012045","DOI":"10.1258\/ebm.2012.012045"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"42.\tHavlenova T, Skaroupkova P, Miklovic M, Behounek M, Chmel M, Jarkovska D, Sviglerova J, ET AL. Right versus left ventricular remodeling in heart failure due to chronic volume overload. Sci Rep 2021;11:17136. https:\/\/doi.org\/10.1038\/s41598-021-96618-8","DOI":"10.21203\/rs.3.rs-399870\/v1"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43.\tWang Y, Xu E, Musich PR, Lin F. Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. CNS Neurosci Ther 2019;25:816-824. https:\/\/doi.org\/10.1111\/cns.13116","DOI":"10.1111\/cns.13116"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"44.\tNavarro A, L\u00f3pez-Cepero JM, B\u00e1ndez MJ, S\u00e1nchez-Pino MJ, G\u00f3mez C, Cadenas E, Boveris A. Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol 2008;294:501-509. https:\/\/doi.org\/10.1152\/ajpregu.00492.2007","DOI":"10.1152\/ajpregu.00492.2007"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45.\tPopa-Wagner A, Sandu RE, Cristin C, Uzoni A, Welle KA, Hryhorenko JR, Ghaemmaghami S. Increased degradation rates in the components of the mitochondrial oxidative phosphorylation chain in the cerebellum of old mice. Front Aging Neurosci 2018;10:32. https:\/\/doi.org\/10.3389\/fnagi.2018.00032","DOI":"10.3389\/fnagi.2018.00032"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46.\tTichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J. Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 2020;10:5418. https:\/\/doi.org\/10.1038\/s41598-020-62308-0","DOI":"10.1038\/s41598-020-62308-0"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"47.\tTieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle 2018;9:3-19. https:\/\/doi.org\/10.1002\/jcsm.12238","DOI":"10.1002\/jcsm.12238"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"48.\tO'Toole JF, Patel HV, Naples CJ, Fujioka H, Hoppel CL. Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria. Biochem J 2010;427:105-112. https:\/\/doi.org\/10.1042\/BJ20091373","DOI":"10.1042\/bj20091373"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"49.\tReijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud D-J, ET AL. Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLoS One 2016;11:e0149419. https:\/\/doi.org\/10.1371\/journal.pone.0149419","DOI":"10.1371\/journal.pone.0149419"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"50.\tPandya JD, Valdez M, Royland JE, MacPhail RC, Sullivan PG, Kodavanti PRS. Age- and organ-specific differences in mitochondrial bioenergetics in Brown Norway Rats. J Aging Res 2020;2020:7232614. https:\/\/doi.org\/10.1155\/2020\/7232614","DOI":"10.1155\/2020\/7232614"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"51.\tJusto R, Boada J, Frontera M, Oliver J, Berm\u00fadez J, Gianotti M. Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis. Am J Physiol Cell Physiol 2005;289:372-378. https:\/\/doi.org\/10.1152\/ajpcell.00035.2005","DOI":"10.1152\/ajpcell.00035.2005"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"52.\tVentura-Clapier R, Moulin M, Piquereau J, Lemaire C, Mericskay M, Veksler V, Garnier A. Mitochondria: a central target for sex differences in pathologies. Clin Sci (Lond) 2017;131:803-822. https:\/\/doi.org\/10.1042\/CS20160485","DOI":"10.1042\/cs20160485"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:36:27Z","timestamp":1674552987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/2022\/71_S227.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":52,"journal-issue":{"issue":"Suppl. 2","published-online":{"date-parts":[[2022,12,30]]}},"URL":"https:\/\/doi.org\/10.33549\/physiolres.934995","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,30]]}}}