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Mitochondrial respiration in the renal cortex of SNX rats was significantly reduced in all measured respiratory states if expressed per unit wet weight and remained lower if recalculated per IU citrate synthase activity, i.e. per mitochondrial mass. In contrast, the profound decrease in the activity of CS in SNX medulla resulted in significantly elevated respiratory states expressing the OXPHOS capacity when Complexes I and II or II only are provided with electrons, LEAK respiration after oligomycin injection, and Complex IV-linked oxygen consumption per unit CS activity suggesting compensatory hypermetabolic state in remaining functional mitochondria that is not sufficient to fully compensate for respiratory deficit expressed per tissue mass. The results document that CKD induced by 5\/6 nephrectomy in the rat is likely to cause not only mitochondrial respiratory dysfunction (in the kidney cortex), but also adaptive changes in the medulla that tend to at least partially compensate for mitochondria loss.<\/jats:p>","DOI":"10.33549\/physiolres.935000","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:36:10Z","timestamp":1674552970000},"page":"S219-S226","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondrial Dysfunction in Kidney Cortex and Medulla of Subtotally Nephrectomized Rat"],"prefix":"10.33549","volume":"71","author":[{"given":"J","family":"JEDLI\u010cKA","sequence":"first","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"GRUNDMANOV\u00c1","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"\u0160V\u00cdGLEROV\u00c1","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"T\u016eMA","sequence":"additional","affiliation":[{"name":"Biomedical Centre, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"NALOS","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"RAJDL","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"\u0160TENGL","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"KUNCOV\u00c1","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine in Plze\u0148, Charles University, Plze\u0148, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tCoresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van LF, Levey AS: Prevalence of chronic kidney disease in the United States. 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