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The rats in the SHR + Choline + NaHS group were intraperitoneally injected with NaHS (100 \u03bcmol\/kg\/day, a hydrogen sulfide (H2S) donor) for 3 months. After 3 months, left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), the indicators of cardiac function measured by echocardiography, were increased significantly in SHR as compared to WKY, although there was no significant difference in collagen volumes and Bax\/Bcl-2 ratio between the two groups, indicating the early stage of cardiac hypertrophy. There was a significant decrease in LVEF and LVFS and an increase in collagen volumes and Bax\/Bcl-2 ratio in SHR fed with choline, meanwhile, plasma H2S levels were significantly decreased significantly in SHR fed with choline accompanying by the decrease of cystathionine-\u03b3-lyase (CSE) activity. Three months of NaHS significantly increased plasma H2S levels, ameliorated cardiac dysfunction and inhibited cardiac fibrosis and apoptosis in SHR fed with choline. In conclusion, choline aggravated cardiac dysfunction in HHD through inhibiting the production of endogenous H2S, which was reversed by supplementation of exogenous H2S donor.<\/jats:p>","DOI":"10.33549\/physiolres.935075","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:06:36Z","timestamp":1704287196000},"page":"719-730","source":"Crossref","is-referenced-by-count":4,"title":["Choline induced cardiac dysfunction by inhibiting the production of endogenous hydrogen sulfide in spontaneously hypertensive rats"],"prefix":"10.33549","author":[{"given":"W","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Harrison DG, Coffman TM, Wilcox CS. 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