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Histologic examinations of the cardiac tissues were performed through hematoxylin and eosin staining and TUNEL staining. The Vehicle group had worse cardiac function, higher levels of cardiac injury markers, and enhanced myocardial apoptosis than the Sham group. The rats in the VNS groups had enhanced cardiac function, lower levels of cardiac injury markers, and inhibited myocardial apoptosis than those in the Vehicle group. Elevated interleukin-1\u03b2 and tumor necrosis factor-\u03b1levels and activated nuclear factor kappa B (NF-\u03baB) signal in septic shock rats were inhibited by the performance of VNS. This study suggests that VNS contributes to the reduction of myocardial apoptosis and improvement of left ventricular function to attenuate septic shock-induced cardiac injury in rats. The performance of VNS inhibits the inflammatory responses in heart tissues via the regulation of NF-\u03baB signal.<\/jats:p>","DOI":"10.33549\/physiolres.935136","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T12:58:34Z","timestamp":1704286714000},"page":"731-739","source":"Crossref","is-referenced-by-count":1,"title":["Vagus nerve stimulation attenuates septic shock-induced cardiac injury in rats"],"prefix":"10.33549","author":[{"given":"Y","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Emergency Brain Academy District, Cangzhou Central Hospital, Cangzhou, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Emergency Brain Academy District, Cangzhou Central Hospital, Cangzhou, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Emergency Brain Academy District, Cangzhou Central Hospital, Cangzhou, Hebei, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Standl T, Annecke T, Cascorbi I, Heller AR, Sabashnikov A, Teske W. 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