{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:31:35Z","timestamp":1790022695516,"version":"4.0.1"},"reference-count":55,"publisher":"Institute of Physiology of the Czech Academy of Sciences","issue":"5\/2024","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>The purpose of this study was to determine the effects of resistance training (RT) alongside creatine-hydrochloride (Cr-HCl) or creatine monohydrate (CrM) supplementation on anabolic\/catabolic hormones, strength, and body composition. Forty participants with an age range of 18-25 years were randomly divided into four groups (n=10): RT+Cr-HCl (0.03 g.kg-1 of body mass), RT+CrM-loading phase (CrM-LP) (0.3 g.kg-1 of body mass for five days (loading) and 0.03 g.kg-1 body mass for 51 days (maintenance)), RT+CrM-without loading phase (CrM-WLP) (0.03 g.kg-1 body mass), and RT+placebo (PL). The participants consumed supplements and performed RT with an intensity of \n70-85 % 1RM for eight weeks. Before and after the training and supplementation period, strength (1RM), body composition (percent body fat (PBF), skeletal muscle mass (SMM), muscular cross-sectional area (MCSA)) and serum levels of testosterone, growth hormone (GH), insulin-like growth factor-1 (IGF-1), cortisol, adrenocorticotropic hormone (ACTH), follistatin and myostatin were measured. The results showed that in the supplementation groups, strength, arm and thigh MCSA, and SMM significantly increased, and PBF significantly decreased (P\u22640.05); this change was significant compared to the PL group (P\u22640.05). In addition, the results showed a significant increase in GH, IGF-1 levels, the ratio of follistatin\/myostatin, testosterone\/cortisol (P\u22640.05), and a significant decrease in cortisol and ACTH levels (P\u22640.05) in the supplementation groups. Hormonal changes in GH, IGF-1, testosterone\/cortisol, cortisol, and ACTH levels in the supplementation groups were significant compared to the PL group (P\u22640.05). The results showed that CrM and Cr-HCl significantly enhanced the beneficial effects of RT on strength, hypertrophy, and hormonal responses, with Cr-HCl showing no benefit over CrM.<\/jats:p>","DOI":"10.33549\/physiolres.935323","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T12:44:07Z","timestamp":1731674647000},"page":"739-753","source":"Crossref","is-referenced-by-count":6,"title":["Supplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic\/Catabolic Hormones, Strength and Body Composition?"],"prefix":"10.33549","author":[{"given":"E","family":"Eghbali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Arazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tBraissant O, Henry H, Beard E, Uldry J. 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