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Pancreatic enzymatic indicators and thyroid hormones were detected, pathology scores were evaluated, and morphological changes were observed under light microscopy and transmission electron microscopy (TEM) in both groups. The serum levels of triiodothyronine (T3), tetraiodothyronine (T4) and Ca2+ were significantly lower in the SAP group than in the control group (P&lt;0.05), whereas the level of calcitonin (CT) was significantly higher than that in the control group (P&lt;0.05). The thyroid structure (pathology and electron microscopy) of the SAP rats was seriously damaged and worsened over time. SAP can cause thyroid injury through a variety of mechanisms, which can also retroact to pancreatitis to aggravate the inflammatory response. This study may have theoretical significance for basic research on SAP.<\/jats:p>","DOI":"10.33549\/physiolres.935403","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T12:36:29Z","timestamp":1742819789000},"page":"105-114","source":"Crossref","is-referenced-by-count":0,"title":["The Structure and Functional Changes of Thyroid in Severe Acute Pancreatitis Rats"],"prefix":"10.33549","author":[{"given":"B","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tSzatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, Beyer G, Sutton R. 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