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The TgF344-AD rat model is a double transgenic model that carries two human gene mutations: APP with the Swedish mutation and PSEN-1 with \u0394 exon 9 mutations. This model exhibits a complete repertoire of AD pathology in an age-dependent manner. This review summarizes multidisciplinary research insights gained from studying TgF344-AD rats in the context of AD pathology. We explore neuropathological findings; electrophysiological assessments revealing disrupted synaptic transmission, reduced spatial coding, network-level dysfunctions, and altered sleep architecture; behavioral studies highlighting impaired spatial memory; alterations in excitatory-inhibitory systems; and molecular and physiological changes in TgF344-AD rats emphasizing their age-related effects. Additionally, the impact of various interventions studied in the model is compiled, underscoring their role in bridging gaps in understanding AD pathogenesis. The TgF344-AD rat model offers significant potential in identifying biomarkers for early detection and therapeutic interventions, providing a robust platform for advancing translational AD research.<\/jats:p>","DOI":"10.33549\/physiolres.935464","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T12:10:50Z","timestamp":1742559050000},"page":"1-17","source":"Crossref","is-referenced-by-count":10,"title":["Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer\u2019s Disease Research"],"prefix":"10.33549","author":[{"given":"A","family":"Nataraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Blahna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Je\u017eek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tKnopman DS, Amieva H, Petersen RC, Ch\u00e9telat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nat Rev Dis Primers 2021;7:33. https:\/\/doi.org\/10.1038\/s41572-021-00269-y","DOI":"10.1038\/s41572-021-00269-y"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.\tSelkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81:741-766. https:\/\/doi.org\/10.1152\/physrev.2001.81.2.741","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.\tBreijyeh Z, Karaman R. Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules 2020;25:5789. https:\/\/doi.org\/10.3390\/molecules25245789","DOI":"10.3390\/molecules25245789"},{"key":"ref3","unstructured":"4.\t2020 Alzheimer's disease facts and figures. Alzheimers Dement. Published online March 10, 2020."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5.\tSloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, Boustani M, Sudha S. The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances. Annu Rev Public Health 2002;23:213-231. https:\/\/doi.org\/10.1146\/annurev.publhealth.23.100901.140525","DOI":"10.1146\/annurev.publhealth.23.100901.140525"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6.\tGhiso J, Frangione B. Amyloidosis and Alzheimer's disease. Adv Drug Deliv Rev 2002;54:1539-1551. https:\/\/doi.org\/10.1016\/S0169-409X(02)00149-7","DOI":"10.1016\/S0169-409X(02)00149-7"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7.\tBraak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-259. https:\/\/doi.org\/10.1007\/BF00308809","DOI":"10.1007\/bf00308809"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.\tWirths O, Zampar S. Neuron Loss in Alzheimer's Disease: Translation in Transgenic Mouse Models. Int J Mol Sci 2020;21:8144. https:\/\/doi.org\/10.3390\/ijms21218144","DOI":"10.3390\/ijms21218144"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.\tAgostinho P, Cunha RA, Oliveira C. Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease. Curr Pharm Des 2010;16:2766-2778. https:\/\/doi.org\/10.2174\/138161210793176572","DOI":"10.2174\/138161210793176572"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.\tRossor MN, Newman S, Frackowiak RS, Lantos P, Kennedy AM. Alzheimer's disease families with amyloid precursor protein mutations. Ann N Y Acad Sci 1993;695:198-202. https:\/\/doi.org\/10.1111\/j.1749-6632.1993.tb23052.x","DOI":"10.1111\/j.1749-6632.1993.tb23052.x"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.\tChen B, Marquez-Nostra B, Belitzky E, Toyonaga T, Tong J, Huang Y, Cai Z. PET Imaging in Animal Models of Alzheimer's Disease. Front Neurosci 2022;16:872509. https:\/\/doi.org\/10.3389\/fnins.2022.872509","DOI":"10.3389\/fnins.2022.872509"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.\tDu AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, et al. Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain 2007;130:1159-1166. https:\/\/doi.org\/10.1093\/brain\/awm016","DOI":"10.1093\/brain\/awm016"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13.\tRyan NS, Rossor MN. Correlating familial Alzheimer's disease gene mutations with clinical phenotype. Biomark Med 2010;4:99-112. https:\/\/doi.org\/10.2217\/bmm.09.92","DOI":"10.2217\/bmm.09.92"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.\tKim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009;63:287-303. https:\/\/doi.org\/10.1016\/j.neuron.2009.06.026","DOI":"10.1016\/j.neuron.2009.06.026"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.\tWolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R. The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives. Int J Mol Sci 2018;20:81. https:\/\/doi.org\/10.3390\/ijms20010081","DOI":"10.3390\/ijms20010081"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.\tBierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, et al. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J Neurochem 1995;64:749-760. https:\/\/doi.org\/10.1046\/j.1471-4159.1995.64020749.x","DOI":"10.1046\/j.1471-4159.1995.64020749.x"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.\tHardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383-388. https:\/\/doi.org\/10.1016\/0165-6147(91)90609-V","DOI":"10.1016\/0165-6147(91)90609-v"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.\tGames D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995;373:523-527. https:\/\/doi.org\/10.1038\/373523a0","DOI":"10.1038\/373523a0"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.\tBenedikz E, Kloskowska E, Winblad B. The rat as an animal model of Alzheimer's disease. J Cell Mol Med 2009;13:1034-1042. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00781.x","DOI":"10.1111\/j.1582-4934.2009.00781.x"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.\tCohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric a\u03b2, and frank neuronal loss. J Neurosci 2013;33:6245-6256. https:\/\/doi.org\/10.1523\/JNEUROSCI.3672-12.2013","DOI":"10.1523\/jneurosci.3672-12.2013"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21.\tDo Carmo S, Cuello AC. Modeling Alzheimer's disease in transgenic rats. Mol Neurodegener 2013;8:37. https:\/\/doi.org\/10.1186\/1750-1326-8-37","DOI":"10.1186\/1750-1326-8-37"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.\tFolkesson R, Malkiewicz K, Kloskowska E, Nilsson T, Popova E, Bogdanovic N, Ganten U, et al. A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation. Biochem Biophys Res Commun 2007;358:777-782. https:\/\/doi.org\/10.1016\/j.bbrc.2007.04.195","DOI":"10.1016\/j.bbrc.2007.04.195"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.\tKloskowska E, Pham TM, Nilsson T, Zhu S, Oberg J, Codita A, Pedersen LA, et al. Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease. J Cell Mol Med 2010;14:1816-1823. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00809.x","DOI":"10.1111\/j.1582-4934.2009.00809.x"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.\tEcheverria V, Ducatenzeiler A, Alhonen L, Janne J, Grant SM, Wandosell F, Muro A, et al. Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. J Alzheimers Dis 2004;6:209-219. https:\/\/doi.org\/10.3233\/JAD-2004-6301","DOI":"10.3233\/jad-2004-6301"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.\tEcheverria V, Ducatenzeiler A, Dowd E, J\u00e4nne J, Grant SM, Szyf M, Wandosell F, et al. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience 2004;129:583-592. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.07.036","DOI":"10.1016\/j.neuroscience.2004.07.036"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26.\tLeon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, et al. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. J Alzheimers Dis 2010;20:113-126. https:\/\/doi.org\/10.3233\/JAD-2010-1349","DOI":"10.3233\/jad-2010-1349"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27.\tGaleano P, Martino Adami PV, Do Carmo S, Blanco E, Rotondaro C, Capani F, Casta\u00f1o EM, et al. Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease. Front Behav Neurosci 2014;8:321. https:\/\/doi.org\/10.3389\/fnbeh.2014.00321","DOI":"10.3389\/fnbeh.2014.00321"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.\tPetrasek T, Vojtechova I, Lobellova V, Popelikova A, Janikova M, Brozka H, Houdek P, et al. The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity. Front Aging Neurosci 2018;10:250. https:\/\/doi.org\/10.3389\/fnagi.2018.00250","DOI":"10.3389\/fnagi.2018.00250"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.\tRorabaugh JM, Chalermpalanupap T, Botz-Zapp CA, Fu VM, Lembeck NA, Cohen RM, Weinshenker D. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain 2017;140:3023-3038. https:\/\/doi.org\/10.1093\/brain\/awx232","DOI":"10.1093\/brain\/awx232"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30.\tBac B, Hicheri C, Weiss C, Buell A, Vilcek N, Spaeni C, Geula C, et al. The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease. Neurobiol Aging 2023;123:98-110. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.12.015","DOI":"10.2139\/ssrn.4268955"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.\tMorrone CD, Lai AY, Bishay J, Hill ME, McLaurin J. Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease. Transl Neurodegener 2022;11:26. https:\/\/doi.org\/10.1186\/s40035-022-00300-6","DOI":"10.1186\/s40035-022-00300-6"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32.\tPentkowski NS, Berkowitz LE, Thompson SM, Drake EN, Olguin CR, Clark BJ. Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease. Neurobiol Aging 2018;61:169-176. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.09.024","DOI":"10.1016\/j.neurobiolaging.2017.09.024"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33.\tBerkowitz LE, Harvey RE, Drake E, Thompson SM, Clark BJ. Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer's disease rats in the Morris Water Task. Sci Rep 2018;8:16153. https:\/\/doi.org\/10.1038\/s41598-018-34368-w","DOI":"10.1101\/282392"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.\tProskauer Pena SL, Mallouppas K, Oliveira AMG, Zitricky F, Nataraj A, Jezek K. Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer's Disease TgF-344 AD. Brain Sci 2021;11:1300. https:\/\/doi.org\/10.3390\/brainsci11101300","DOI":"10.3390\/brainsci11101300"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35.\tSagalajev B, Lennartz L, Vieth L, Gunawan CT, Neumaier B, Drzezga A, Visser-Vandewalle V, et al. TgF344-AD Rat Model of Alzheimer's Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration. J Alzheimers Dis Rep 2023;7:1085-1094. https:\/\/doi.org\/10.3233\/ADR-230038","DOI":"10.3233\/adr-230038"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36.\tChaudry O, Ndukwe K, Xie L, Figueiredo-Pereira M, Serrano P, Rockwell P. Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats. Sci Rep 2022;12:19129. https:\/\/doi.org\/10.1038\/s41598-022-23801-w","DOI":"10.1038\/s41598-022-23801-w"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37.\tSrivastava H, Lasher AT, Nagarajan A, Sun LY. Sexual dimorphism in the peripheral metabolic homeostasis and behavior in the TgF344-AD rat model of Alzheimer's disease. Aging Cell 2023;22:e13854. https:\/\/doi.org\/10.1111\/acel.13854","DOI":"10.1111\/acel.13854"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38.\tTournier BB, Barca C, Fall AB, Gloria Y, Meyer L, Ceyz\u00e9riat K, Millet P. Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease. Genes Brain Behav 2021;20:e12712. https:\/\/doi.org\/10.1111\/gbb.12712","DOI":"10.1111\/gbb.12712"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"39.\tFowler CF, Goerzen D, Devenyi GA, Madularu D, Chakravarty MM, Near J. Neurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model. Brain Commun 2022;4:fcac072. https:\/\/doi.org\/10.1093\/braincomms\/fcac072","DOI":"10.58530\/2022\/3254"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"40.\tSar\u00e9 RM, Cooke SK, Krych L, Zerfas PM, Cohen RM, Smith CB. Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer's Disease. Front Neurosci 2020;14:601. https:\/\/doi.org\/10.3389\/fnins.2020.00601","DOI":"10.3389\/fnins.2020.00601"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41.\tPentkowski NS, Bouquin SJ, Maestas-Olguin CR, Villasenor ZM, Clark BJ. Differential effects of chronic stress on anxiety-like behavior and contextual fear conditioning in the TgF344-AD rat model of Alzheimer's disease. Behav Brain Res 2022;418:113661. https:\/\/doi.org\/10.1016\/j.bbr.2021.113661","DOI":"10.1016\/j.bbr.2021.113661"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"42.\tHope T, Tilling KM, Gedling K, Keene JM, Cooper SD, Fairburn CG. The structure of wandering in dementia. Int J Geriat Psychiatry 1994;9:149-155. https:\/\/doi.org\/10.1002\/gps.930090209","DOI":"10.1002\/gps.930090209"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43.\tKlement D, Blahna K, Nekov\u00e1\u0159ov\u00e1 T. Novel behavioral tasks for studying spatial cognition in rats. Physiol Res 2008;57(Suppl 3):S161-S165. https:\/\/doi.org\/10.33549\/physiolres.931609","DOI":"10.33549\/physiolres.931609"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"44.\tO'Keefe J, Dostrovsky J. The hippocampus as a spatial map: Preliminary evidence from unit activity in the freely-moving rat. Brain Res 1971;34:171-175. https:\/\/doi.org\/10.1016\/0006-8993(71)90358-1","DOI":"10.1016\/0006-8993(71)90358-1"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45.\tJezek K, Lee BB, Kelemen E, McCarthy KM, McEwen BS, Fenton AA. Stress-induced out-of-context activation of memory. PLoS Biol 2010;8:e1000570. https:\/\/doi.org\/10.1371\/journal.pbio.1000570","DOI":"10.1371\/journal.pbio.1000570"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46.\tJezek K, Wesierska M, Fenton A. Hippocampus-dependent retrieval and hippocampus-independent extinction of place avoidance navigation, and stress-induced out-of-context activation of a memory revealed by reversible lesion experiments in rats. Physiol Res 2002;51(Suppl 1):S35-S47. https:\/\/doi.org\/10.33549\/physiolres.930000.51.S35","DOI":"10.33549\/physiolres.930000.51.s35"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"47.\tKapl S, Tichanek F, Zitricky F, Jezek K. Context-independent expression of spatial code in hippocampus. Sci Rep 2022;12:20711. https:\/\/doi.org\/10.1038\/s41598-022-25006-7","DOI":"10.1101\/2022.03.28.486068"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"48.\tSilva A, Mart\u00ednez MC. Spatial memory deficits in Alzheimer's disease and their connection to cognitive maps' formation by place cells and grid cells. Front Behav Neurosci 2022;16:1082158. https:\/\/doi.org\/10.3389\/fnbeh.2022.1082158","DOI":"10.3389\/fnbeh.2022.1082158"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"49.\tCayzac S, Mons N, Ginguay A, Allinquant B, Jeantet Y, Cho YH. Altered hippocampal information coding and network synchrony in APP-PS1 mice. Neurobiol Aging 2015;36:3200-3213. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.08.023","DOI":"10.1016\/j.neurobiolaging.2015.08.023"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"50.\tCacucci F, Yi M, Wills TJ, Chapman P, O'Keefe J. Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model. Proc Natl Acad Sci U S A 2008;105:7863-7868. https:\/\/doi.org\/10.1073\/pnas.0802908105","DOI":"10.1073\/pnas.0802908105"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"51.\tGalloway CR, Ravipati K, Singh S, Lebois EP, Cohen RM, Levey AI, Manns JR. Hippocampal place cell dysfunction and the effects of muscarinic M1 receptor agonism in a rat model of Alzheimer's disease. Hippocampus 2018;28:568-585. https:\/\/doi.org\/10.1002\/hipo.22961","DOI":"10.1002\/hipo.22961"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"52.\tBroussard JI, Redell JB, Maynard ME, Zhao J, Moore A, Mills RW, Hood KN, et al. Impaired Experience-Dependent Refinement of Place Cells in a Rat Model of Alzheimer's Disease. J Alzheimers Dis 2022;86:1907-1916. https:\/\/doi.org\/10.3233\/JAD-215023","DOI":"10.3233\/jad-215023"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"53.\tNataraj A, Kala A, Proskauer Pena SL, Jezek K, Blahna K. Impaired Dynamics of Positional and Contextual Neural Coding in an Alzheimer's Disease Rat Model. J Alzheimers Dis 2024;101:259-276. https:\/\/doi.org\/10.3233\/JAD-231386","DOI":"10.3233\/jad-231386"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"54.\tLue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999;155:853-862. https:\/\/doi.org\/10.1016\/S0002-9440(10)65184-X","DOI":"10.1016\/s0002-9440(10)65184-x"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"55.\tSmith LA, McMahon LL. Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model. Neurobiol Dis 2018;110:166-179. https:\/\/doi.org\/10.1016\/j.nbd.2017.11.014","DOI":"10.1016\/j.nbd.2017.11.014"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"56.\tGoodman AM, Langner BM, Jackson N, Alex C, McMahon LL. Heightened Hippocampal \u03b2-Adrenergic Receptor Function Drives Synaptic Potentiation and Supports Learning and Memory in the TgF344-AD Rat Model during Prodromal Alzheimer's Disease. J Neurosci 2021;41:5747-5761. https:\/\/doi.org\/10.1523\/JNEUROSCI.0119-21.2021","DOI":"10.1523\/jneurosci.0119-21.2021"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"57.\tSmith LA, Goodman AM, McMahon LL. Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease. Front Synaptic Neurosci 2022;14:826601. https:\/\/doi.org\/10.3389\/fnsyn.2022.826601","DOI":"10.3389\/fnsyn.2022.826601"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"58.\tHernandez CM, Jackson NL, Hernandez AR, McMahon LL. Impairments in Fear Extinction Memory and Basolateral Amygdala Plasticity in the TgF344-AD Rat Model of Alzheimer's Disease Are Distinct from Nonpathological Aging. eNeuro 2022;9:ENEURO.0181-22.2022. https:\/\/doi.org\/10.1523\/ENEURO.0181-22.2022","DOI":"10.1523\/eneuro.0181-22.2022"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"59.\tMampay M, Velasco-Estevez M, Rolle SO, Chaney AM, Boutin H, Dev KK, Moeendarbary E, et al. Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats. FEBS Open Bio 2021;11:146-163. https:\/\/doi.org\/10.1002\/2211-5463.13036","DOI":"10.1002\/2211-5463.13036"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"60.\tAmoss\u00e9 Q, Ceyz\u00e9riat K, Tsartsalis S, Tournier BB, Millet P. Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue (FACS-RTT) to Determine the Cellular Origin of Radioactive Signal. 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Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv 2024:2024.01.11.575200. https:\/\/doi.org\/10.1101\/2024.01.11.575200","DOI":"10.1101\/2024.01.11.575200"},{"key":"ref95","doi-asserted-by":"publisher","unstructured":"96.\tRutkowsky JM, Roland Z, Valenzuela A, Nguyen AB, Park HH, Six N, Dursun I, et al. The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats. Aging (Albany NY) 2024;16:5811-5828. https:\/\/doi.org\/10.18632\/aging.205741","DOI":"10.18632\/aging.205741"},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"97.\tKavkova M, Zikmund T, Kala A, Salplachta J, Proskauer Pena SL, Kaiser J, Jezek K. Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system. 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Biol Psychiatry 2018;84:488-498. https:\/\/doi.org\/10.1016\/j.biopsych.2017.10.023","DOI":"10.1016\/j.biopsych.2017.10.023"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"102.\tStoiljkovic M, Kelley C, Horvath TL, Haj\u00f3s M. Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats. Alzheimers Res Ther 2018;10:105. https:\/\/doi.org\/10.1186\/s13195-018-0433-4","DOI":"10.1186\/s13195-018-0433-4"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"103.\tBazzigaluppi P, Beckett TL, Koletar MM, Hill ME, Lai A, Trivedi A, Thomason L, et al. Combinatorial Treatment Using Umbilical Cord Perivascular Cells and A\u03b2 Clearance Rescues Vascular Function Following Transient Hypertension in a Rat Model of Alzheimer Disease. Hypertension 2019;74:1041-1051. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.13187","DOI":"10.1161\/hypertensionaha.119.13187"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"104.\tLeplus A, Lauritzen I, Melon C, Kerkerian-Le Goff L, Fontaine D, Checler F. Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss. Brain Struct Funct 2019;224:363-372. https:\/\/doi.org\/10.1007\/s00429-018-1779-x","DOI":"10.1007\/s00429-018-1779-x"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"105.\tCeyz\u00e9riat K, Zilli T, Fall AB, Millet P, Koutsouvelis N, Dipasquale G, Frisoni GB, et al. Treatment by low-dose brain radiation therapy improves memory performances without changes of the amyloid load in the TgF344-AD rat model. Neurobiol Aging 2021;103:117-127. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.03.008","DOI":"10.1016\/j.neurobiolaging.2021.03.008"},{"key":"ref105","doi-asserted-by":"publisher","unstructured":"106.\tCeyz\u00e9riat K, Zilli T, Millet P, Koutsouvelis N, Dipasquale G, Fossey C, Cailly T, et al. Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats. J Neuroinflammation 2022;19:311. https:\/\/doi.org\/10.1186\/s12974-022-02673-x","DOI":"10.1186\/s12974-022-02673-x"},{"key":"ref106","doi-asserted-by":"publisher","unstructured":"107.\tWu C, Yang L, Li Y, Dong Y, Yang B, Tucker LD, Zong X, et al. Effects of Exercise Training on Anxious-Depressive-like Behavior in Alzheimer Rat. 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