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There are published reports, particularly on preclinical level, that N-acetylcysteine (NAC) may affect addictive properties of different classes of drugs (e.g., cocaine, heroin, alcohol, cannabinoids, nicotine). Since the lack of information on possible effects of NAC on amphetamine derivatives we decided to test possible influence of this substance on behavioral sensitization to methamphetamine (MET) in the mouse open field test. Our results have shown a decreased acute stimulatory effect of MET caused by NAC and moreover, there was a non-significant trend of attenuated development of behavioral sensitization to MET after simultaneous long-term administration of MET and NAC. This suppression of MET stimulatory effects therefore suggested on the preclinical level possible promising efficacy of NAC on addictive properties associated with MET similarly as it was demonstrated by other authors in association with cocaine or heroin.<\/jats:p>","DOI":"10.33549\/physiolres.935471","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:24:58Z","timestamp":1747747498000},"page":"337-346","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of N-Acetylcysteine on Behavioral Sensitization to Methamphetamine in Mice"],"prefix":"10.33549","author":[{"given":"A","family":"M\u00e1chalov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Landa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. landa@med.muni.cz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"M\u00e1chal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Demlov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sl\u00edva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Robinson TE, Berridge KC. 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