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Granulosa cells, integral to follicular development, play a pivotal role in follicle maturation. Recent studies have established a strong correlation between granulosa cell programmed cell death and follicular atresia in PCOS. This review provides a comprehensive analysis of the current understanding of granulosa cell programmed cell death and its contribution to follicular atresia within the pathophysiology of PCOS, providing a foundation for future research endeavors.<\/jats:p>","DOI":"10.33549\/physiolres.935485","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T08:41:20Z","timestamp":1742546480000},"page":"31-40","source":"Crossref","is-referenced-by-count":28,"title":["Mechanisms of Granulosa Cell Programmed Cell Death and Follicular Atresia in Polycystic Ovary Syndrome"],"prefix":"10.33549","author":[{"given":"Y-H","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-J","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tAjmal N, Khan SZ, Shaikh R. 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