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Conducted at a southern Taiwan university, this quasi-experimental study involved RPS interventions at specified frequencies, with pre and post assessments of heartbeat, blood pressure, and heart rate variability. Among 62 participants (average age 20.29\u00b10.61), those without depression showed a notable blood pressure reduction following theta-frequency RPS compared to other frequencies (p&lt;0.05). A similar pattern was observed when comparing non-depressed and depressed participants after theta-RPS, with depressed individuals experiencing an increase in sympathetic activity (p&lt;0.05). RPS, particularly at theta frequency, can significantly influence the autonomic nervous system, suggesting a potential for reducing anxiety-related physiological markers in university students. Further verification with a larger and longitudinal study is warranted.<\/jats:p>","DOI":"10.33549\/physiolres.935496","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:09:08Z","timestamp":1742821748000},"page":"149-160","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Rhythmic Photic Stimulation for Autonomic Nervous System Regulation in University Students"],"prefix":"10.33549","author":[{"given":"S-Y","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-C","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-M","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-H","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.\tShah TD, Pol T. 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