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Notably, recent attention has been directed towards the detrimental impact of micro- and nanoplastic pollution on mitochondrial integrity, an area underscored by a paucity of comprehensive investigations. Given the escalating prevalence of plastic particle contamination and the concomitant burden of cardiovascular disease in aging populations, understanding the interplay between mitochondria within the cardiovascular system and micro- and nanoplastic pollution assumes paramount importance. This review endeavors to elucidate the current albeit limited comprehension surrounding this complex interplay.<\/jats:p>","DOI":"10.33549\/physiolres.935500","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T14:12:43Z","timestamp":1736777563000},"page":"S685-S695","source":"Crossref","is-referenced-by-count":16,"title":["Influence of Micro- and Nanoplastics on Mitochondrial Function in the Cardiovascular System: A Review of the Current Literature"],"prefix":"10.33549","author":[{"given":"T","family":"Lerchner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Jedli\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kripnerov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dejmek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kuncov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.\tBhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis 2017;1863:1066-1077. https:\/\/doi.org\/10.1016\/j.bbadis.2016.11.010","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.\tMarin-Garcia J and Akhmedov AT. Mitochondrial dynamics and cell death in heart failure. Heart Fail Rev 2016;21:123-136. https:\/\/doi.org\/10.1007\/s10741-016-9530-2","DOI":"10.1007\/s10741-016-9530-2"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3.\tPrata JC. Airborne microplastics: Consequences to human health? Environ Pollut 2018;234:115-126. https:\/\/doi.org\/10.1016\/j.envpol.2017.11.043","DOI":"10.1016\/j.envpol.2017.11.043"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4.\tWallace DC. Mitochondria and cancer. Nat Rev Cancer 2012;12:685-698. https:\/\/doi.org\/10.1038\/nrc3365","DOI":"10.1038\/nrc3365"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5.\tNunnari J and Suomalainen A. Mitochondria: in sickness and in health. Cell 2012;148:1145-1159. https:\/\/doi.org\/10.1016\/j.cell.2012.02.035","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.\tRaimundo N. Mitochondrial pathology: stress signals from the energy factory. Trends Mol Med 2014;20:282-292. https:\/\/doi.org\/10.1016\/j.molmed.2014.01.005","DOI":"10.1016\/j.molmed.2014.01.005"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"7.\tAndrady AL. Microplastics in the marine environment. Mar Pollut Bull 2011;62:1596-1605. https:\/\/doi.org\/10.1016\/j.marpolbul.2011.05.030","DOI":"10.1016\/j.marpolbul.2011.05.030"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.\tAllen S, Allen, D, Phoenix VR, Le Roux G, Jim\u00e9nez PD, Simonneau A, Binet S, Galop D. Atmospheric transport and deposition of microplastics in a remote mountain catchment. Nat Geosci 2019;12:339-344. https:\/\/doi.org\/10.1038\/s41561-019-0335-5","DOI":"10.1038\/s41561-019-0335-5"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.\tBesseling E, Redondo-Hasselerharm P, Foekema EM, Koelmans AA. Quantifying ecological risks of aquatic micro- and nanoplastic. Crit Rev Env Sci Tec 2018;49:32-80. https:\/\/doi.org\/10.1080\/10643389.2018.1531688","DOI":"10.1080\/10643389.2018.1531688"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.\tLuo D, Chu X, Wu Y, Wang Z, Liao Z, Ji X, Ju J, ET AL. Micro- and nano-plastics in the atmosphere: A review of occurrence, properties and human health risks. J Hazard Mater 2024;465:133412. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.133412","DOI":"10.1016\/j.jhazmat.2023.133412"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.\tPradel A, Catrouillet C, Gigault J. The environmental fate of nanoplastics: What we know and what we need to know about aggregation. NanoImpact 2023;29:100453. https:\/\/doi.org\/10.1016\/j.impact.2023.100453","DOI":"10.1016\/j.impact.2023.100453"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.\tCole M, Lindeque P, Fileman E, Halsband C, Goodhead R, Moger J, Galloway TS. Microplastic ingestion by zooplankton. Environ Sci Technol 2013;47:6646-6655. https:\/\/doi.org\/10.1021\/es400663f","DOI":"10.1021\/es400663f"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13.\tRochman CM, Tahir A, Williams SL, Baxa DV, Lam R, Miller JT, ET AL. Anthropogenic debris in seafood: Plastic debris and fibers from textiles in fish and bivalves sold for human consumption. Sci Rep 2015;5:14340. https:\/\/doi.org\/10.1038\/srep14340","DOI":"10.1038\/srep14340"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.\tVan Cauwenberghe L and Janssen CR. Microplastics in bivalves cultured for human consumption. Environ Pollut 2014;193:65-70. https:\/\/doi.org\/10.1016\/j.envpol.2014.06.010","DOI":"10.1016\/j.envpol.2014.06.010"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.\tBrowne MA, Dissanayake A, Galloway TS, Lowe DM, Thompson RC. Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L). Environ Sci Technol 2008;42:5026-5031. https:\/\/doi.org\/10.1021\/es800249a","DOI":"10.1021\/es800249a"},{"key":"ref15","unstructured":"16.\tBastyans S, Jackson S, Fejer G. Micro and nano-plastics, a threat to human health? Emerg Top Life Sci 2022;6:411-422. https:\/\/doi.org\/10.1042\/ETLS20220024"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.\tWright SL, Thompson RC, Galloway TS. The physical impacts of microplastics on marine organisms: a review. Environ Pollut 2013;178:483-492. https:\/\/doi.org\/10.1016\/j.envpol.2013.02.031","DOI":"10.1016\/j.envpol.2013.02.031"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.\tMattsson K, Ekvall MT, Hansson LA, Linse S, Malmendal A, Cedervall T. Altered behavior, physiology, and metabolism in fish exposed to polystyrene nanoparticles. Environ Sci Technol 2015;49:553-561. https:\/\/doi.org\/10.1021\/es5053655","DOI":"10.1021\/es5053655"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.\tZhang Q, Xu EG, Li J, Chen Q, Ma L, Zeng EY, Shi H. A Review of Microplastics in Table Salt, Drinking Water, and Air: Direct Human Exposure. 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Impact of Micro- and Nanoplastics on Mitochondria. Metabolites 2022;12:897. https:\/\/doi.org\/10.3390\/metabo12100897","DOI":"10.3390\/metabo12100897"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.\tLeslie HA, van Velzen MJM, Brandsma SH, Vethaak AD, Garcia-Vallejo JJ, Lamoree MH. Discovery and quantification of plastic particle pollution in human blood. Environ Int 2022;163:107199. https:\/\/doi.org\/10.1016\/j.envint.2022.107199","DOI":"10.1016\/j.envint.2022.107199"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.\tGeppner L, Ramer G, Tomasetig D, Grundh\u00f6fer L, K\u00fcss J, Kaup M, Henjakovic M. A novel enzymatic method for isolation of plastic particles from human blood. Environ Toxicol Pharmacol 2023;104:104318. https:\/\/doi.org\/10.1016\/j.etap.2023.104318","DOI":"10.1016\/j.etap.2023.104318"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.\tGuo X, Wang L, Wang X, Li D, Wang H, Xu H, Liu Y, ET AL. Discovery and analysis of microplastics in human bone marrow. J Hazard Mater 2024;477:135266. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135266","DOI":"10.1016\/j.jhazmat.2024.135266"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26.\tWang K, Du Y, Li P, Guan C, Zhou M, Wu L, Liu Z, Huang Z. Nanoplastics causes heart aging\/myocardial cell senescence through the Ca(2+)\/mtDNA\/cGAS-STING signaling cascade. J Nanobiotechnology 2024;22:96. https:\/\/doi.org\/10.1186\/s12951-024-02375-x","DOI":"10.1186\/s12951-024-02375-x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27.\tDeLoid GM, Cao X, Bitounis D, Singh D, Llopis PM, Buckley B, Demokritou P. Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium. Food Chem Toxicol 2021;158:112609. https:\/\/doi.org\/10.1016\/j.fct.2021.112609","DOI":"10.1016\/j.fct.2021.112609"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.\tLennicke C and Cocheme HM. Redox metabolism: ROS as specific molecular regulators of cell signaling and function. Mol Cell 2021;81:3691-3707. https:\/\/doi.org\/10.1016\/j.molcel.2021.08.018","DOI":"10.1016\/j.molcel.2021.08.018"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.\tChen YR and Zweier JL. Cardiac mitochondria and reactive oxygen species generation. Circ Res 2014;114:524-537. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.300559","DOI":"10.1161\/circresaha.114.300559"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30.\tWei J, Wang X, Liu Q, Zhou N, Zhu S, Li Z, Li X, Yao J, Zhang L. The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3\/Caspase-1 signaling pathway and oxidative stress in Wistar rats. Environ Toxicol 2021;36:935-944. https:\/\/doi.org\/10.1002\/tox.23095","DOI":"10.1002\/tox.23095"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.\tLu T, Li D, Yuan X, Wang Z, Shao Z, Feng X, Yang C, ET AL. Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart. Cardiovasc Toxicol 2024;24:291-301. https:\/\/doi.org\/10.1007\/s12012-024-09837-6","DOI":"10.1007\/s12012-024-09837-6"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32.\tZhang T, Yang S, Ge Y, Wan X, Zhu Y, Yang F, Li J, ET AL. Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics. Part Fibre Toxicol 2023;20:46. https:\/\/doi.org\/10.1186\/s12989-023-00557-3","DOI":"10.1186\/s12989-023-00557-3"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33.\tDuan Z, Wang J, Zhang H, Wang Y, Chen Y, Cong J, Gong Z, ET AL. Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development. J Hazard Mater 2023;458:131679. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.131679","DOI":"10.1016\/j.jhazmat.2023.131679"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.\tVlacil AK, B\u00e4nfer S, Jacob R, Trippel N, Kuzu I, Schieffer B, Grote K. Polystyrene microplastic particles induce endothelial activation. PLoS One 2021;16:e0260181. https:\/\/doi.org\/10.1371\/journal.pone.0260181","DOI":"10.1371\/journal.pone.0260181"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35.\tFu Y, Fan M, Xu L, Wang H, Hu Q, Jin Y. Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells. 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