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Sodium depletion excessively activates the renin-angiotensin-aldosterone system (RAAS), which stimulates NHE, reduces sodium loss, and mitigates late metabolic acidosis. Interestingly, NaCl supplementation suppresses systemic RAS activity while also preventing late metabolic acidosis, potentially through renal RAS-mediated NHE upregulation. Circulating and renal RAS may have distinct roles in regulating NHE activation and in maturity-related changes in sodium and acid-base homeostasis in premature infants.<\/jats:p>","DOI":"10.33549\/physiolres.935622","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:38:01Z","timestamp":1773221881000},"page":"3","source":"Crossref","is-referenced-by-count":0,"title":["The role of renal Na+\/H+ exchange in the regulation of acid-base and sodium homeostasis in premature infants"],"prefix":"10.33549","author":[{"given":"E","family":"Sulyok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mauchart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1","family":"V\u00e1rnagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"B\u00f3dis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.\tPitts RF. 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