{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:33Z","timestamp":1785404493129,"version":"3.56.0"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>This study aimed to examine the association between serum Secreted Frizzled-Related Protein 1 (SFRP1) levels and the presence of coronary artery calcification (CAC) in patients with Stage 5D chronic kidney disease (CKD) undergoing maintenance hemodialysis (MHD). A case-control study was conducted involving 76 patients with CKD Stage 5D undergoing MHD. Participants were stratified into three groups based on Coronary Artery Calcium Scores (CACS): non-calcified (CACS &lt; 100), low-score calcification (100 \u2264 CACS \u2264 400), and high-score calcification (CACS &gt; 400). Serum concentrations of SFRP1, hemoglobin, albumin, ferritin, C-reactive protein (CRP), calcium, phosphorus, 25-hydroxyvitamin D, and intact parathyroid hormone were measured. Correlations between biochemical parameters and CAC were evaluated, and multivariate linear regression analysis was employed to identify independent risk factors for CAC. CAC was detected in 60.5 % of the study population. Serum SFRP1 concentrations were significantly elevated in the high-score calcification group compared to both the low-score and non-calcified groups, with the lowest levels observed in the non-calcified group (p &lt; 0.01). Positive correlations were observed between CAC and serum levels of SFRP1 levels, phosphorus, age, hemoglobin, alkaline phosphatase, and age. Multivariate linear regression analysis identified serum SFRP1 and phosphorus levels as independent risk factors for CAC in this population (p &lt; 0.05). Receiver operating characteristic (ROC) curve analysis demonstrated that serum SFRP1 levels yielded an area under the curve (AUC) of 0.898 (95 % CI: 0.826\u20130.970, p &lt; 0.0001) for predicting CAC, with a Youden index of 0.738 at a cut-off value of 4.242 ng\/ml. Elevated serum SFRP1 levels were associated with an increased likelihood of CAC in patients with Stage 5D CKD undergoing MHD. These findings suggest that SFRP1 may represent a potential biomarker for identifying patients at risk for CAC in this population.<\/jats:p>","DOI":"10.33549\/physiolres.935693","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:56:20Z","timestamp":1778954180000},"page":"277","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum SFRP1 Levels and Coronary Artery Calcification in Stage 5D Chronic Kidney Disease Undergoing Maintenance Hemodialysis"],"prefix":"10.33549","author":[{"given":"H","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mdjbm03","id-type":"ROR","asserted-by":"publisher"}],"name":"Fourth Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2026,5,12]]},"container-title":["Physiological Research"],"original-title":[],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:56:21Z","timestamp":1778954181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/2026\/75_277.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.935693","relation":{},"ISSN":["1802-9973"],"issn-type":[{"value":"1802-9973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}