{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:48:25Z","timestamp":1790484505186,"version":"4.1.0"},"reference-count":0,"publisher":"Aerospace Medical Association","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["aerosp med hum perform"],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Artificial hypergravity has been proposed to prevent or treat various forms of physiological deconditioning experienced during spaceflight. We have previously reported that cerebral blood flow decreased at 15\u221221 min of +1.5-G<jats:sub>z<\/jats:sub> centrifugation without\n decreases in arterial pressure at heart level. We reanalyzed our previous data to clarify time-dependent changes in cerebral blood flow and arterial pressure during mild +G<jats:sub>z<\/jats:sub> hypergravity.<jats:bold>METHOD:<\/jats:bold> We reanalyzed data for 0\u201320 min during +1.5-G<jats:sub>z<\/jats:sub> centrifugation\n on 13 male subjects for whom physiological data were steadily recorded. Mean cerebral blood flow velocity in the middle cerebral artery (MCBFV<jats:sub>MCA<\/jats:sub>), mean arterial pressure at heart level (MAP<jats:sub>heart<\/jats:sub>), and middle cerebral artery level (MAP<jats:sub>MCA<\/jats:sub>) during centrifugation\n were averaged every 5 min and compared with prehypergravity data (+1.0 G<jats:sub>z<\/jats:sub>, 5 min).<jats:bold>RESULTS:<\/jats:bold> MAP<jats:sub>heart<\/jats:sub> did not change significantly, but MAP<jats:sub>MCA<\/jats:sub> decreased significantly throughout centrifugation compared to prehypergravity data (\u221216.7% to \u221224.7%).\n MCBFV<jats:sub>MCA<\/jats:sub> tended to be decreased at 0\u20135 min of +1.5-G<jats:sub>z<\/jats:sub> centrifugation (\u22123.3%), but this was not statistically significant. MCBFV<jats:sub>MCA<\/jats:sub> was significantly decreased at 5\u201310 min (\u22125.5%). MCBFV<jats:sub>MCA<\/jats:sub> at 10\u201315 min and 15\u201320\n min were also significantly decreased to almost the same level (\u22126.9% and \u22126.8%, respectively).<jats:bold>DISCUSSION:<\/jats:bold> No significant change in MAP<jats:sub>heart<\/jats:sub> was detected, whereas MAP<jats:sub>MCA<\/jats:sub> decreased significantly from the beginning of +1.5-G<jats:sub>z<\/jats:sub> centrifugation.\n On the other hand, MCBFV<jats:sub>MCA<\/jats:sub> gradually decreased and became roughly flat in the latter half of 20-min centrifugation. Understanding the different time-dependent changes in cerebral blood flow and arterial pressure under mild +G<jats:sub>z<\/jats:sub> hypergravity might be important for implementation\n of centrifuging as a countermeasure for spaceflight-induced deconditioning.<jats:bold>Konishi T, Kurazumi T, Kato T, Takko C, Ogawa Y, Iwasaki K. <jats:italic>Time-dependent changes in cerebral blood flow and arterial pressure during mild +G<\/jats:italic><\/jats:bold><jats:sub><jats:bold><jats:italic>z<\/jats:italic><\/jats:bold><\/jats:sub><jats:bold><jats:italic> hypergravity<\/jats:italic>. Aerosp\n Med Hum Perform. 2018; 89(9):787\u2013791.<\/jats:bold><\/jats:p>","DOI":"10.3357\/amhp.5106.2018","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T04:33:41Z","timestamp":1534826021000},"page":"787-791","source":"Crossref","is-referenced-by-count":7,"title":["Time-Dependent Changes in Cerebral Blood Flow and Arterial Pressure During Mild +Gz Hypergravity"],"prefix":"10.3357","volume":"89","author":[{"given":"Toru","family":"Konishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kurazumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Takko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yojiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1911","container-title":["Aerospace Medicine and Human Performance"],"original-title":[],"link":[{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/89\/9\/article-p787.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/89\/9\/article-p787.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/89\/9\/article-p787.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:33:17Z","timestamp":1728304397000},"score":1,"resource":{"primary":{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/89\/9\/article-p787.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":0,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.3357\/amhp.5106.2018","relation":{},"ISSN":["2375-6314","2375-6322"],"issn-type":[{"value":"2375-6314","type":"print"},{"value":"2375-6322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}