{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:51:07Z","timestamp":1791607867445,"version":"4.3.4"},"reference-count":14,"publisher":"Aerospace Medical Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["aerosp med hum perform"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p><jats:bold>INTRODUCTION:<\/jats:bold> Optic disc edema has been well documented in astronauts both during and after long-duration spaceflight and is hypothesized to largely result from increased pressure within the orbital subarachnoid space brought about by a generalized rise in intracranial pressure\n or from sequestration of cerebrospinal fluid within the orbital subarachnoid space with locally elevated optic nerve sheath pressure. In addition, a recent prospective study documented substantial spaceflight-associated peripapillary choroidal thickening, which may be a contributing factor\n in spaceflight-associated neuro-ocular syndrome. In the present article, based on the above, we offer a new perspective on the pathogenesis of microgravity-induced optic disc edema from a choroidal point of view. We propose that prolonged microgravity exposure may result in the transudation\n of fluid from the choroidal vasculature, which, in turn, may reach the optic nerve head, and ultimately may lead to fluid stasis within the prelaminar region secondary to impaired ocular glymphatic outflow. If confirmed, this viewpoint would shed new light on the development of optic disc\n edema in astronauts.<jats:bold>Wostyn P, Gibson CR, Mader TH. <jats:italic>Optic disc edema in astronauts from a choroidal point of view<\/jats:italic>. Aerosp Med Hum Perform. 2022; 93(4):396\u2013398.<\/jats:bold><\/jats:p>","DOI":"10.3357\/amhp.6010.2022","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:50:46Z","timestamp":1648702246000},"page":"396-398","source":"Crossref","is-referenced-by-count":16,"title":["Optic Disc Edema in Astronauts from a Choroidal Point of View"],"prefix":"10.3357","volume":"93","author":[{"given":"Peter","family":"Wostyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Mader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1911","reference":[{"issue":"10","key":"B1","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1167\/iovs.18-24463","article-title":"The impact of choroidal swelling on optic nerve 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