{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:19:59Z","timestamp":1790021999092,"version":"4.0.1"},"reference-count":18,"publisher":"Aerospace Medical Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["aerosp med hum perform"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Tactical aviators require administration of enhanced inspired oxygen concentrations (hyperoxia) to reduce risk of hypobaric hypoxia and decompression injuries. Hyperoxia is not without consequence; it reduces cerebral perfusion (CBF). Characterizing the relationship\n between F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> and CBF is necessary to establish F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> levels that do not reduce CBF yet are sufficient to mitigate risk of in-flight physiological stressors. To achieve that goal, this study\u2019s objective was to determine whether a dose-response\n relationship exists between F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> and CBF and, if so, the F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> at which CBF significantly declines.<jats:bold>METHODS:<\/jats:bold> Healthy male and female subjects (<jats:italic>N<\/jats:italic> = 26) were randomized to receive either low dose F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> of 30%, 40%,\n 50%, and 100% (Arm 1) or high dose F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> of 60%, 70%, 80%, and 100% (Arm 2), followed by a return to 21% for both groups. Subjects were placed within a 3-Tesla MRI scanner equipped with pseudocontinuous arterial spin labeling software (pCASL) to measure CBF. Baseline CBF\n measurements were obtained during exposure to 21% F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub>, with subsequent CBF measurements obtained at each predetermined F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> level.<jats:bold>RESULTS:<\/jats:bold> Baseline CBF did not differ between subjects in Arm 1 and Arm 2. Low dose F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub>\n \u2264 50% did not affect CBF. In contrast, high dose F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> \u2265 60% significantly reduced CBF. Exposure to 100% F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> led to similar reductions of CBF for subjects in both Arm 1 and Arm 2.<jats:bold>DISCUSSION:<\/jats:bold> The neurovascular system appears to respond\n to increasing F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> levels in a dose dependent manner, with significant reductions in CBF with F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> exposures \u2265 60%.<jats:bold>Damato EG, Fillioe SJ, Vannix IS, Norton LK, Margevicius SP, Beebe JL, Decker MJ. <jats:italic>Characterizing the dose response of\n hyperoxia with brain perfusion<\/jats:italic>. Aerosp Med Hum Perform. 2022; 93(6):493\u2013498.<\/jats:bold><\/jats:p>","DOI":"10.3357\/amhp.6056.2022","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:32:16Z","timestamp":1655872336000},"page":"493-498","source":"Crossref","is-referenced-by-count":10,"title":["Characterizing the Dose Response of Hyperoxia with Brain Perfusion"],"prefix":"10.3357","volume":"93","author":[{"given":"Elizabeth G.","family":"Damato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth J.","family":"Fillioe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Vannix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily K.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee P.","family":"Margevicius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Beebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1911","reference":[{"issue":"18","key":"B1","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1113\/JP279453","article-title":"Neurovascular and cortical responses to hyperoxia: enhanced cognition and electroencephalographic activity despite reduced perfusion","volume":"598","author":"Damato","year":"2020","journal-title":"J Physiol."},{"issue":"8","key":"B2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3357\/ASEM.2941.2011","article-title":"In-flight hypoxia events in tactical jet aviation: characteristics compared to normobaric training","volume":"82","author":"Deussing","year":"2011","journal-title":"Aviat Space Environ Med."},{"issue":"6","key":"B3","first-page":"2453","article-title":"Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA. 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