{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:57:13Z","timestamp":1789469833916,"version":"build-2803163510"},"reference-count":68,"publisher":"Aerospace Medical Association","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    <jats:bold>INTRODUCTION:<\/jats:bold>\n                    Acute mountain sickness (AMS) is a common condition in individuals ascending rapidly to high altitudes and often presents with headaches, fatigue, and gastrointestinal symptoms. AMS is prevalent above 16,000 ft (4900 m), but some individuals experience it at lower elevations. This pilot study assessed the prevalence and timing of AMS symptoms in unacclimatized individuals exposed to 16,000 ft (4900 m) in a controlled hypobaric environment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    A total of 10 healthy, unacclimatized men and women were exposed to an altitude of 16,000 ft (4900 m) for 5 h. Physiological parameters, including heart rate (HR), oxygen saturation (S\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    ), and respiratory rate (RR), were recorded alongside AMS symptom severity using the 2018 Lake Louise Questionnaire (LLQ) and divided into low, moderate, and high responders based on severity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    All subjects experienced some degree of AMS symptoms, with LLQ scores increasing over time. Two subjects could not complete the full exposure due to moderate and severe symptoms. HR increased (\u0394 = 7.0 \u00b1 0.6), while S\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    remained stable but lower than baseline (\u0394 = 9 \u00b1 4.2). LLQ score increases were strongly correlated with HR, S\n                    <jats:sub>p<\/jats:sub>\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    , and RR. RR remained stable across subjects but varied between AMS severity groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DISCUSSION:<\/jats:bold>\n                    This pilot study demonstrated that unacclimatized individuals rapidly exposed to 13,000 ft (4900 m) develop AMS symptoms in a controlled environment. The correlation between LLQ scores and physiological changes offers insight into AMS pathophysiology, supporting the need for further research into AMS susceptibility and genetic factors.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      Murphey JT, Hess HW, Schwob J, Monaco BA, Clemency BM, Hostler D.\n                      <jats:italic>Acute mountain sickness symptoms after rapid ascent to 4900 m<\/jats:italic>\n                      . Aerosp Med Hum Perform. 2025; 96(11):958\u2013963.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.3357\/amhp.6661.2025","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T21:31:02Z","timestamp":1763760662000},"page":"958-963","source":"Crossref","is-referenced-by-count":2,"title":["Acute Mountain Sickness Symptoms After Rapid Ascent to 4900 m"],"prefix":"10.3357","volume":"96","author":[{"given":"Joshua T.","family":"Murphey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden W.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Schwob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Clemency","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hostler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1911","reference":[{"issue":"6","key":"B1","series-title":"Prog Cardiovasc Dis.","first-page":"467","article-title":"Acute mountain sickness: pathophysiology, prevention, and treatment","volume":"52","author":"Imray C","year":"2010","unstructured":"Imray C, Wright A, Subudhi A, Roach R. Acute mountain sickness: pathophysiology, prevention, and treatment. Prog Cardiovasc Dis. 2010 May-Jun; 52(6):467\u201384."},{"issue":"2","key":"B2","series-title":"High Alt Med Biol.","first-page":"170","article-title":"Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness","volume":"19","author":"Wang C","year":"2018","unstructured":"Wang C, Jiang H, Duan J, Chen J, Wang Q,  Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. 2018 Jun; 19(2):170\u20137."},{"issue":"2","key":"B3","series-title":"Sleep Breath.","first-page":"103","article-title":"Prediction of the susceptibility to AMS in simulated altitude","volume":"12","author":"Burtscher M","year":"2008","unstructured":"Burtscher M, Szubski C, Faulhaber M. Prediction of the susceptibility to AMS in simulated altitude. Sleep Breath. 2008 May; 12(2):103\u20138."},{"issue":"1","key":"B4","series-title":"High Alt Med Biol.","first-page":"4","article-title":"The 2018 Lake Louise Acute Mountain Sickness Score","volume":"19","author":"Roach RC","year":"2018","unstructured":"Roach RC, Hackett PH, Oelz O, B\u00e4rtsch P, Luks AM,  The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol. 2018 Mar; 19(1):4\u20136."},{"issue":"3","key":"B5","series-title":"Respir Physiol.","first-page":"383","article-title":"Acute mountain sickness and the edemas of high altitude: a common pathogenesis?","volume":"46","author":"Hackett PH","year":"1981","unstructured":"Hackett PH, Rennie D, Grover RF, Reeves JT. Acute mountain sickness and the edemas of high altitude: a common pathogenesis? Respir Physiol. 1981 Dec; 46(3):383\u201390."},{"issue":"2","key":"B6","series-title":"Ann Intern Med.","first-page":"190","article-title":"Polycythemia in association with pulmonary disorders","volume":"7","author":"Waring JJ","year":"1933","unstructured":"Waring JJ, Yegge WB. Polycythemia in association with pulmonary disorders. Ann Intern Med. 1933 Aug; 7(2):190\u2013208."},{"key":"B7","article-title":"High altitude pulmonary edema","author":"Jensen JD","year":"2023","unstructured":"Jensen JD, Vincent AL. High altitude pulmonary edema. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. Accessed April 11, 2023. Available from http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430819\/."},{"issue":"22","key":"B8","series-title":"Cell Mol Life Sci.","first-page":"3583","article-title":"Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological","volume":"66","author":"Bailey DM","year":"2009","unstructured":"Bailey DM, B\u00e4rtsch P, Knauth M, Baumgartner RW. Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological. Cell Mol Life Sci. 2009 Nov; 66(22):3583\u201394."},{"issue":"18","key":"B9","series-title":"N Engl J Med.","first-page":"1284","article-title":"Prevention of high-altitude pulmonary edema by nifedipine","volume":"325","author":"B\u00e4rtsch P","year":"1991","unstructured":"B\u00e4rtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of high-altitude pulmonary edema by nifedipine. N Engl J Med. 1991 Oct 31; 325(18):1284\u20139."},{"issue":"1","key":"B10","series-title":"J Appl Physiol (1985).","first-page":"313","article-title":"High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?","volume":"131","author":"Turner REF","year":"2021","unstructured":"Turner REF, Gatterer H, Falla M, Lawley JS. High-altitude cerebral edema: its own entity or end-stage acute mountain sickness? J Appl Physiol (1985). 2021 Jul 1; 131(1):313\u201325."},{"issue":"3","key":"B11","series-title":"Respir Physiol.","first-page":"365","article-title":"Pattern of breathing and mouth occlusion pressure during acclimatization to high altitude","volume":"40","author":"Gautier H","year":"1980","unstructured":"Gautier H, Milic-Emili J, Miserocchi G, Siafakas NM. Pattern of breathing and mouth occlusion pressure during acclimatization to high altitude. Respir Physiol. 1980 Jun; 40(3):365\u201377."},{"issue":"2","key":"B12","series-title":"High Alt Med Biol.","first-page":"192","article-title":"Physiological responses in humans acutely exposed to high altitude (3480 m): minute ventilation and oxygenation are predictive for the development of acute mountain sickness","volume":"20","author":"Burtscher M","year":"2019","unstructured":"Burtscher M, Philadelphy M, Gatterer H, Burtscher J, Faulhaber M,  Physiological responses in humans acutely exposed to high altitude (3480 m): minute ventilation and oxygenation are predictive for the development of acute mountain sickness. High Alt Med Biol. 2019 Jun; 20(2):192\u20137."},{"issue":"4","key":"B13","series-title":"High Alt Med Biol.","first-page":"271","article-title":"Hypoxemia and acute mountain sickness: which comes first?","volume":"9","author":"Loeppky JA","year":"2008","unstructured":"Loeppky JA, Icenogle MV, Charlton GA, Conn CA, Maes D,  Hypoxemia and acute mountain sickness: which comes first? High Alt Med Biol. 2008 Winter; 9(4):271\u20139."},{"issue":"4","key":"B14","series-title":"J Travel Med.","first-page":"247","article-title":"Hypoxia\u2010related altitude illnesses","volume":"20","author":"Netzer N","year":"2013","unstructured":"Netzer N, Strohl K, Faulhaber M, Gatterer H, Burtscher M. Hypoxia\u2010related altitude illnesses. J Travel Med. 2013 Jul-Aug; 20(4):247\u201355."},{"issue":"973","key":"B15","series-title":"Postgrad Med J.","first-page":"748","article-title":"Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia","volume":"82","author":"Clarke C.","year":"2006","unstructured":"Clarke C. Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia. Postgrad Med J. 2006 Nov; 82(973):748\u201353."},{"issue":"2","key":"B16","series-title":"N Engl J Med.","first-page":"107","article-title":"High-altitude illness","volume":"345","author":"Hackett PH","year":"2001","unstructured":"Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001 Jul 12; 345(2):107\u201314."},{"issue":"8","key":"B17","series-title":"Ann Intern Med.","first-page":"587","article-title":"Acute mountain sickness in a general tourist population at moderate altitudes","volume":"118","author":"Honigman B","year":"1993","unstructured":"Honigman B, Theis MK, Koziol-McLain J, Roach R, Yip R,  Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med. 1993 Apr 15; 118(8):587."},{"key":"B18","series-title":"Front Physiol.","first-page":"709804","article-title":"Urinary metabolites as predictors of acute mountain sickness severity","volume":"12","author":"Sibomana I","year":"2021","unstructured":"Sibomana I, Foose DP, Raymer ML, Reo NV, Karl JP,  Urinary metabolites as predictors of acute mountain sickness severity. Front Physiol. 2021 Sep 13; 12:709804."},{"key":"B19","series-title":"Front Physiol.","first-page":"1397280","article-title":"Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications","volume":"15","author":"Wang B","year":"2024","unstructured":"Wang B, Chen S, Song J, Huang D, Xiao G. Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications. Front Physiol. 2024 Jun 24; 15:1397280."},{"issue":"1","key":"B20","series-title":"Commun Biol.","first-page":"548","article-title":"Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort","volume":"5","author":"Yang J","year":"2022","unstructured":"Yang J, Jia Z, Song X, Shi J, Wang X,  Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort. Commun Biol. 2022 Jun 6; 5(1):548."},{"issue":"13","key":"B21","series-title":"N Engl J Med.","first-page":"841","article-title":"Current concepts. Acute mountain sickness","volume":"319","author":"Johnson TS","year":"1988","unstructured":"Johnson TS, Rock PB. Current concepts. Acute mountain sickness. N Engl J Med. 1988 Sep 29; 319(13):841\u20135."},{"issue":"11","key":"B22","series-title":"J Clin Invest.","first-page":"5638","article-title":"Hypoxia-inducible factor signaling in pulmonary hypertension","volume":"130","author":"Pullamsetti SS","year":"2020","unstructured":"Pullamsetti SS, Mamazhakypov A, Weissmann N, Seeger W, Savai R. Hypoxia-inducible factor signaling in pulmonary hypertension. J Clin Invest. 2020 Nov 2; 130(11):5638\u201351."},{"key":"B23","series-title":"Biol Res.","first-page":"13","article-title":"Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease","volume":"49","author":"Iturriaga R","year":"2016","unstructured":"Iturriaga R, Del Rio R, Idiaquez J, Somers VK. Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease. Biol Res. 2016 Feb 26; 49:13."},{"issue":"1","key":"B24","series-title":"Respir Physiol Neurobiol.","first-page":"9","article-title":"Role of chemoreceptors in mediating dyspnea","volume":"167","author":"Buchanan GF","year":"2009","unstructured":"Buchanan GF, Richerson GB. Role of chemoreceptors in mediating dyspnea. Respir Physiol Neurobiol. 2009 May 30; 167(1):9\u201319."},{"issue":"5","key":"B25","series-title":"Am J Physiol Regul Integr Comp Physiol.","first-page":"R1473","article-title":"Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation","volume":"296","author":"Ainslie PN","year":"2009","unstructured":"Ainslie PN, Duffin J. Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1473\u201395."},{"key":"B26","series-title":"Wilderness Environ Med.","first-page":"2S","article-title":"Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 update","volume":"35","author":"Luks AM","year":"2024","unstructured":"Luks AM, Beidleman BA, Freer L, Grissom CK, Keyes LE,  Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 update. Wilderness Environ Med. 2024 Mar; 35(1 Suppl):2S\u201319S."},{"key":"B27","first-page":"63","article-title":"Tibetan and Andean contrasts in adaptation to high-altitutde hypoxia","author":"Beall CM.","year":"2002","unstructured":"Beall CM. Tibetan and Andean contrasts in adaptation to high-altitutde hypoxia. In: Lahiri S, Prabhakar NR, Forster RE, eds. Oxygen sensing: molecule to man. Advances in Experimental Medicine and Biology, vol 475. New York (NY): Kluwer Academic Publishers; 2002:63\u201374."},{"issue":"2","key":"B28","series-title":"J Occup Environ Med.","first-page":"159","article-title":"The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness","volume":"53","author":"MacInnis MJ","year":"2011","unstructured":"MacInnis MJ, Wang P, Koehle MS, Rupert JL. The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness. J Occup Environ Med. 2011 Feb; 53(2):159\u201368."},{"issue":"6","key":"B29","series-title":"Physiology (Bethesda).","first-page":"403","article-title":"The genetic basis of chronic mountain sickness","volume":"29","author":"Ronen R","year":"2014","unstructured":"Ronen R, Zhou D, Bafna V, Haddad GG. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403\u201312."},{"issue":"1","key":"B30","series-title":"Sci Rep.","first-page":"5414","article-title":"EDN1 gene potentially involved in the development of acute mountain sickness","volume":"10","author":"Yu J","year":"2020","unstructured":"Yu J, Liu C, Zhang C, Bian S, Yang J,  EDN1 gene potentially involved in the development of acute mountain sickness. Sci Rep. 2020 Mar 25; 10(1):5414."},{"key":"B31","series-title":"Eur Respir J.","first-page":"PA1809","article-title":"Acute mountain sickness in women \u2013 a pilot study","volume":"62","author":"Taalaibekova A","year":"2023","unstructured":"Taalaibekova A, Meyer M, Ulrich S, Mirzalieva G, Mademilov M,  Acute mountain sickness in women \u2013 a pilot study. Eur Respir J. 2023; 62(suppl 67):PA1809."},{"issue":"10","key":"B32","series-title":"J Clin Med.","first-page":"2869","article-title":"Sex-specific difference in the effect of altitude on sleep and nocturnal breathing in young healthy volunteers","volume":"11","author":"Li T","year":"2022","unstructured":"Li T, Tan L, Furian M, Zhang Y, Luo L,  Sex-specific difference in the effect of altitude on sleep and nocturnal breathing in young healthy volunteers. J Clin Med. 2022 May 19; 11(10):2869."},{"issue":"1","key":"B33","series-title":"Mil Med Res.","first-page":"38","article-title":"Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis","volume":"6","author":"Hou YP","year":"2019","unstructured":"Hou YP, Wu JL, Tan C, Chen Y, Guo R, Luo YJ. Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis. Mil Med Res. 2019 Dec 9; 6(1):38."},{"issue":"18","key":"B34","series-title":"J Exp Biol.","first-page":"3161","article-title":"Frontiers of hypoxia research: acute mountain sickness","volume":"204","author":"Roach RC","year":"2001","unstructured":"Roach RC, Hackett PH. Frontiers of hypoxia research: acute mountain sickness. J Exp Biol. 2001 Sep; 204(18):3161\u201370."},{"issue":"6","key":"B1","series-title":"Prog Cardiovasc Dis.","first-page":"467","article-title":"Acute mountain sickness: pathophysiology, prevention, and treatment","volume":"52","author":"Imray C","year":"2010","unstructured":"Imray C, Wright A, Subudhi A, Roach R. Acute mountain sickness: pathophysiology, prevention, and treatment. Prog Cardiovasc Dis. 2010 May-Jun; 52(6):467\u201384."},{"issue":"2","key":"B2","series-title":"High Alt Med Biol.","first-page":"170","article-title":"Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness","volume":"19","author":"Wang C","year":"2018","unstructured":"Wang C, Jiang H, Duan J, Chen J, Wang Q,  Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. 2018 Jun; 19(2):170\u20137."},{"issue":"2","key":"B3","series-title":"Sleep Breath.","first-page":"103","article-title":"Prediction of the susceptibility to AMS in simulated altitude","volume":"12","author":"Burtscher M","year":"2008","unstructured":"Burtscher M, Szubski C, Faulhaber M. Prediction of the susceptibility to AMS in simulated altitude. Sleep Breath. 2008 May; 12(2):103\u20138."},{"issue":"1","key":"B4","series-title":"High Alt Med Biol.","first-page":"4","article-title":"The 2018 Lake Louise Acute Mountain Sickness Score","volume":"19","author":"Roach RC","year":"2018","unstructured":"Roach RC, Hackett PH, Oelz O, B\u00e4rtsch P, Luks AM,  The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol. 2018 Mar; 19(1):4\u20136."},{"issue":"3","key":"B5","series-title":"Respir Physiol.","first-page":"383","article-title":"Acute mountain sickness and the edemas of high altitude: a common pathogenesis?","volume":"46","author":"Hackett PH","year":"1981","unstructured":"Hackett PH, Rennie D, Grover RF, Reeves JT. Acute mountain sickness and the edemas of high altitude: a common pathogenesis? Respir Physiol. 1981 Dec; 46(3):383\u201390."},{"issue":"2","key":"B6","series-title":"Ann Intern Med.","first-page":"190","article-title":"Polycythemia in association with pulmonary disorders","volume":"7","author":"Waring JJ","year":"1933","unstructured":"Waring JJ, Yegge WB. Polycythemia in association with pulmonary disorders. Ann Intern Med. 1933 Aug; 7(2):190\u2013208."},{"key":"B7","article-title":"High altitude pulmonary edema","author":"Jensen JD","year":"2023","unstructured":"Jensen JD, Vincent AL. High altitude pulmonary edema. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. Accessed April 11, 2023. Available from http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430819\/."},{"issue":"22","key":"B8","series-title":"Cell Mol Life Sci.","first-page":"3583","article-title":"Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological","volume":"66","author":"Bailey DM","year":"2009","unstructured":"Bailey DM, B\u00e4rtsch P, Knauth M, Baumgartner RW. Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological. Cell Mol Life Sci. 2009 Nov; 66(22):3583\u201394."},{"issue":"18","key":"B9","series-title":"N Engl J Med.","first-page":"1284","article-title":"Prevention of high-altitude pulmonary edema by nifedipine","volume":"325","author":"B\u00e4rtsch P","year":"1991","unstructured":"B\u00e4rtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of high-altitude pulmonary edema by nifedipine. N Engl J Med. 1991 Oct 31; 325(18):1284\u20139."},{"issue":"1","key":"B10","series-title":"J Appl Physiol (1985).","first-page":"313","article-title":"High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?","volume":"131","author":"Turner REF","year":"2021","unstructured":"Turner REF, Gatterer H, Falla M, Lawley JS. High-altitude cerebral edema: its own entity or end-stage acute mountain sickness? J Appl Physiol (1985). 2021 Jul 1; 131(1):313\u201325."},{"issue":"3","key":"B11","series-title":"Respir Physiol.","first-page":"365","article-title":"Pattern of breathing and mouth occlusion pressure during acclimatization to high altitude","volume":"40","author":"Gautier H","year":"1980","unstructured":"Gautier H, Milic-Emili J, Miserocchi G, Siafakas NM. Pattern of breathing and mouth occlusion pressure during acclimatization to high altitude. Respir Physiol. 1980 Jun; 40(3):365\u201377."},{"issue":"2","key":"B12","series-title":"High Alt Med Biol.","first-page":"192","article-title":"Physiological responses in humans acutely exposed to high altitude (3480 m): minute ventilation and oxygenation are predictive for the development of acute mountain sickness","volume":"20","author":"Burtscher M","year":"2019","unstructured":"Burtscher M, Philadelphy M, Gatterer H, Burtscher J, Faulhaber M,  Physiological responses in humans acutely exposed to high altitude (3480 m): minute ventilation and oxygenation are predictive for the development of acute mountain sickness. High Alt Med Biol. 2019 Jun; 20(2):192\u20137."},{"issue":"4","key":"B13","series-title":"High Alt Med Biol.","first-page":"271","article-title":"Hypoxemia and acute mountain sickness: which comes first?","volume":"9","author":"Loeppky JA","year":"2008","unstructured":"Loeppky JA, Icenogle MV, Charlton GA, Conn CA, Maes D,  Hypoxemia and acute mountain sickness: which comes first? High Alt Med Biol. 2008 Winter; 9(4):271\u20139."},{"issue":"4","key":"B14","series-title":"J Travel Med.","first-page":"247","article-title":"Hypoxia\u2010related altitude illnesses","volume":"20","author":"Netzer N","year":"2013","unstructured":"Netzer N, Strohl K, Faulhaber M, Gatterer H, Burtscher M. Hypoxia\u2010related altitude illnesses. J Travel Med. 2013 Jul-Aug; 20(4):247\u201355."},{"issue":"973","key":"B15","series-title":"Postgrad Med J.","first-page":"748","article-title":"Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia","volume":"82","author":"Clarke C.","year":"2006","unstructured":"Clarke C. Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia. Postgrad Med J. 2006 Nov; 82(973):748\u201353."},{"issue":"2","key":"B16","series-title":"N Engl J Med.","first-page":"107","article-title":"High-altitude illness","volume":"345","author":"Hackett PH","year":"2001","unstructured":"Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001 Jul 12; 345(2):107\u201314."},{"issue":"8","key":"B17","series-title":"Ann Intern Med.","first-page":"587","article-title":"Acute mountain sickness in a general tourist population at moderate altitudes","volume":"118","author":"Honigman B","year":"1993","unstructured":"Honigman B, Theis MK, Koziol-McLain J, Roach R, Yip R,  Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med. 1993 Apr 15; 118(8):587."},{"key":"B18","series-title":"Front Physiol.","first-page":"709804","article-title":"Urinary metabolites as predictors of acute mountain sickness severity","volume":"12","author":"Sibomana I","year":"2021","unstructured":"Sibomana I, Foose DP, Raymer ML, Reo NV, Karl JP,  Urinary metabolites as predictors of acute mountain sickness severity. Front Physiol. 2021 Sep 13; 12:709804."},{"key":"B19","series-title":"Front Physiol.","first-page":"1397280","article-title":"Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications","volume":"15","author":"Wang B","year":"2024","unstructured":"Wang B, Chen S, Song J, Huang D, Xiao G. Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications. Front Physiol. 2024 Jun 24; 15:1397280."},{"issue":"1","key":"B20","series-title":"Commun Biol.","first-page":"548","article-title":"Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort","volume":"5","author":"Yang J","year":"2022","unstructured":"Yang J, Jia Z, Song X, Shi J, Wang X,  Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort. Commun Biol. 2022 Jun 6; 5(1):548."},{"issue":"13","key":"B21","series-title":"N Engl J Med.","first-page":"841","article-title":"Current concepts. Acute mountain sickness","volume":"319","author":"Johnson TS","year":"1988","unstructured":"Johnson TS, Rock PB. Current concepts. Acute mountain sickness. N Engl J Med. 1988 Sep 29; 319(13):841\u20135."},{"issue":"11","key":"B22","series-title":"J Clin Invest.","first-page":"5638","article-title":"Hypoxia-inducible factor signaling in pulmonary hypertension","volume":"130","author":"Pullamsetti SS","year":"2020","unstructured":"Pullamsetti SS, Mamazhakypov A, Weissmann N, Seeger W, Savai R. Hypoxia-inducible factor signaling in pulmonary hypertension. J Clin Invest. 2020 Nov 2; 130(11):5638\u201351."},{"key":"B23","series-title":"Biol Res.","first-page":"13","article-title":"Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease","volume":"49","author":"Iturriaga R","year":"2016","unstructured":"Iturriaga R, Del Rio R, Idiaquez J, Somers VK. Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease. Biol Res. 2016 Feb 26; 49:13."},{"issue":"1","key":"B24","series-title":"Respir Physiol Neurobiol.","first-page":"9","article-title":"Role of chemoreceptors in mediating dyspnea","volume":"167","author":"Buchanan GF","year":"2009","unstructured":"Buchanan GF, Richerson GB. Role of chemoreceptors in mediating dyspnea. Respir Physiol Neurobiol. 2009 May 30; 167(1):9\u201319."},{"issue":"5","key":"B25","series-title":"Am J Physiol Regul Integr Comp Physiol.","first-page":"R1473","article-title":"Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation","volume":"296","author":"Ainslie PN","year":"2009","unstructured":"Ainslie PN, Duffin J. Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1473\u201395."},{"key":"B26","series-title":"Wilderness Environ Med.","first-page":"2S","article-title":"Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 update","volume":"35","author":"Luks AM","year":"2024","unstructured":"Luks AM, Beidleman BA, Freer L, Grissom CK, Keyes LE,  Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 update. Wilderness Environ Med. 2024 Mar; 35(1 Suppl):2S\u201319S."},{"key":"B27","first-page":"63","article-title":"Tibetan and Andean contrasts in adaptation to high-altitutde hypoxia","author":"Beall CM.","year":"2002","unstructured":"Beall CM. Tibetan and Andean contrasts in adaptation to high-altitutde hypoxia. In: Lahiri S, Prabhakar NR, Forster RE, eds. Oxygen sensing: molecule to man. Advances in Experimental Medicine and Biology, vol 475. New York (NY): Kluwer Academic Publishers; 2002:63\u201374."},{"issue":"2","key":"B28","series-title":"J Occup Environ Med.","first-page":"159","article-title":"The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness","volume":"53","author":"MacInnis MJ","year":"2011","unstructured":"MacInnis MJ, Wang P, Koehle MS, Rupert JL. The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness. J Occup Environ Med. 2011 Feb; 53(2):159\u201368."},{"issue":"6","key":"B29","series-title":"Physiology (Bethesda).","first-page":"403","article-title":"The genetic basis of chronic mountain sickness","volume":"29","author":"Ronen R","year":"2014","unstructured":"Ronen R, Zhou D, Bafna V, Haddad GG. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403\u201312."},{"issue":"1","key":"B30","series-title":"Sci Rep.","first-page":"5414","article-title":"EDN1 gene potentially involved in the development of acute mountain sickness","volume":"10","author":"Yu J","year":"2020","unstructured":"Yu J, Liu C, Zhang C, Bian S, Yang J,  EDN1 gene potentially involved in the development of acute mountain sickness. Sci Rep. 2020 Mar 25; 10(1):5414."},{"key":"B31","series-title":"Eur Respir J.","first-page":"PA1809","article-title":"Acute mountain sickness in women \u2013 a pilot study","volume":"62","author":"Taalaibekova A","year":"2023","unstructured":"Taalaibekova A, Meyer M, Ulrich S, Mirzalieva G, Mademilov M,  Acute mountain sickness in women \u2013 a pilot study. Eur Respir J. 2023; 62(suppl 67):PA1809."},{"issue":"10","key":"B32","series-title":"J Clin Med.","first-page":"2869","article-title":"Sex-specific difference in the effect of altitude on sleep and nocturnal breathing in young healthy volunteers","volume":"11","author":"Li T","year":"2022","unstructured":"Li T, Tan L, Furian M, Zhang Y, Luo L,  Sex-specific difference in the effect of altitude on sleep and nocturnal breathing in young healthy volunteers. J Clin Med. 2022 May 19; 11(10):2869."},{"issue":"1","key":"B33","series-title":"Mil Med Res.","first-page":"38","article-title":"Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis","volume":"6","author":"Hou YP","year":"2019","unstructured":"Hou YP, Wu JL, Tan C, Chen Y, Guo R, Luo YJ. Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis. Mil Med Res. 2019 Dec 9; 6(1):38."},{"issue":"18","key":"B34","series-title":"J Exp Biol.","first-page":"3161","article-title":"Frontiers of hypoxia research: acute mountain sickness","volume":"204","author":"Roach RC","year":"2001","unstructured":"Roach RC, Hackett PH. Frontiers of hypoxia research: acute mountain sickness. J Exp Biol. 2001 Sep; 204(18):3161\u201370."}],"container-title":["Aerospace Medicine and Human Performance"],"original-title":[],"link":[{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/96\/11\/article-p958.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/96\/11\/article-p958.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/96\/11\/article-p958.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:59:12Z","timestamp":1777082352000},"score":1,"resource":{"primary":{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/96\/11\/article-p958.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":68,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.3357\/amhp.6661.2025","relation":{},"ISSN":["2375-6314","2375-6322"],"issn-type":[{"value":"2375-6314","type":"print"},{"value":"2375-6322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}