{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:39:27Z","timestamp":1777084767445,"version":"3.51.4"},"reference-count":118,"publisher":"Aerospace Medical Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>INTRODUCTION:<\/jats:bold>\n                    Spaceflight presents unique challenges to ocular health, as visual disturbances such as dry eye symptoms have been frequently reported by astronauts. Matrix metalloproteinases (MMPs), a family of extracellular matrix-degrading enzymes, are known mediators of ocular surface inflammation and tissue remodeling on Earth, particularly in dry eye disease. This review explores the potential role of MMPs in spaceflight-associated ocular conditions, including spaceflight-associated dry eye syndrome and spaceflight-associated neuro-ocular syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    We searched literature on topics relating to metallomatrix proteins and spaceflight using databases PubMed, MedLine, Embase, and Central from inception to April 2025.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Although there are limited studies on direct measurements of tear MMPs during spaceflight, indirect clinical evidence and analog studies suggest that microgravity, radiation, and systemic inflammation may upregulate MMP expression. This contributes to epithelial barrier disruption and impaired wound healing. Rodent models and simulated microgravity experiments further support the mechanosensitive regulation of MMPs across various tissues.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DISCUSSION:<\/jats:bold>\n                    Given the safety and accessibility of tear collection, MMPs may be useful biomarkers for assessing ocular and systemic changes in astronauts. Understanding MMP expression and regulation in space may inform preventive strategies to preserve vision during long-duration missions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      Stephanian B, Ong J, Lee R, Gibson R, Berdahl J, Waisberg E, Mader TH, Lee AG.\n                      <jats:italic>Ocular matrix metalloproteinases in spaceflight<\/jats:italic>\n                      . Aerosp Med Hum Perform. 2026; 97(1):47\u201354.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.3357\/amhp.6730.2026","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:42:14Z","timestamp":1770730934000},"page":"47-54","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Matrix Metalloproteinases in Spaceflight"],"prefix":"10.3357","volume":"97","author":[{"given":"Brooke","family":"Stephanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Berdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Waisberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Mader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1911","reference":[{"issue":"1","key":"B1","series-title":"NPJ Microgravity.","first-page":"37","article-title":"Ocular conditions and injuries, detection and management in spaceflight","volume":"9","author":"Meer E","year":"2023","unstructured":"Meer E, Grob S, Antonsen EL, Sawyer A. Ocular conditions and injuries, detection and management in spaceflight. NPJ Microgravity. 2023 May 16; 9(1):37."},{"issue":"9","key":"B2","series-title":"JAMA Ophthalmol.","first-page":"808","article-title":"Severe spaceflight-associated neuro-ocular syndrome in an astronaut with 2 predisposing factors","volume":"142","author":"Brunstetter TJ","year":"2024","unstructured":"Brunstetter TJ, Zwart SR, Brandt K, Brown DM, Clemett SJ,  Severe spaceflight-associated neuro-ocular syndrome in an astronaut with 2 predisposing factors. JAMA Ophthalmol. 2024 Sep 1; 142(9):808\u201317."},{"issue":"5","key":"B3","series-title":"JAMA Ophthalmol.","first-page":"553","article-title":"Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery","volume":"138","author":"Macias BR","year":"2020","unstructured":"Macias BR, Patel NB, Gibson CR, Samuels BC, Laurie SS,  Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery. JAMA Ophthalmol. 2020 May 1; 138(5):553\u20139."},{"issue":"3","key":"B4","series-title":"Biomedicine & Aging Pathology.","first-page":"97","article-title":"Metalloproteinases and eye diseases","volume":"3","author":"Pescosolido N","year":"2013","unstructured":"Pescosolido N, Giannotti R, Buomprisco G. Metalloproteinases and eye diseases. Biomedicine & Aging Pathology. 2013 Jul-Sep; 3(3):97\u2013105."},{"issue":"3","key":"B5","series-title":"Ocul Surf.","first-page":"276","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig JP","year":"2017","unstructured":"Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS,  TFOS DEWS II definition and classification report. Ocul Surf. 2017 Jul; 15(3):276\u201383."},{"key":"B6","series-title":"Exp Eye Res.","first-page":"108523","article-title":"Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome: a review study","volume":"205","author":"Shoari A","year":"2021","unstructured":"Shoari A, Kanavi MR, Rasaee MJ. Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome: a review study. Exp Eye Res. 2021 Apr; 205:108523."},{"key":"B7","article-title":"Background: preflight screening, in-flight capabilities, and postflight testing","author":"Gibson CR","year":"2009","unstructured":"Gibson CR, Duncan J. Background: preflight screening, in-flight capabilities, and postflight testing. Houston (TX): NASA Johnson Space Center; 2009 Jul 27. Report No.: JSC-CN-18652."},{"key":"B8","series-title":"Space physiology and medicine.","first-page":"245","article-title":"Neurology","author":"Reschke MF","year":"2016","unstructured":"Reschke MF, Cl\u00e9ment G, Thorson SL, Harm DL, Mader TH,  Neurology. In: Nicogossian A, Williams R, Huntoon C, Doarn C, Polk J, Scheider V, editors. Space physiology and medicine. New York (NY): Springer; 2016:245\u201382."},{"issue":"1","key":"B9","series-title":"J Neuroophthalmol.","first-page":"84","article-title":"Origins of cerebral edema: implications for spaceflight-associated neuro-ocular syndrome","volume":"40","author":"Galdamez LA","year":"2020","unstructured":"Galdamez LA, Brunstetter TJ, Lee AG, Tarver WJ. Origins of cerebral edema: implications for spaceflight-associated neuro-ocular syndrome. J Neuroophthalmol. 2020 Mar; 40(1):84\u201391."},{"issue":"4","key":"B10","series-title":"Curr Opin Chem Biol.","first-page":"466","article-title":"Matrix metalloproteinases","volume":"2","author":"Johnson LL","year":"1998","unstructured":"Johnson LL, Dyer R, Hupe DJ. Matrix metalloproteinases. Curr Opin Chem Biol. 1998 Aug; 2(4):466\u201371."},{"key":"B11","series-title":"Zinc metalloproteases in health and disease.","first-page":"173","article-title":"Matrix metalloproteinases","author":"Nagase H.","year":"1996","unstructured":"Nagase H. Matrix metalloproteinases. In: Zinc metalloproteases in health and disease. London: Taylor & Francis; 1996 Jul 30:173\u2013224."},{"key":"B12","series-title":"Int Immunopharmacol.","first-page":"105812","article-title":"Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients","volume":"77","author":"Ghasemi H","year":"2019","unstructured":"Ghasemi H, Yaraee R, Faghihzadeh S, Ghassemi-Broumand M, Mahmoudi M,  Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients. Int Immunopharmacol. 2019 Dec; 77:105812."},{"issue":"4","key":"B13","series-title":"Exp Eye Res.","first-page":"449","article-title":"Regulation of MMP-9 production by human corneal epithelial cells","volume":"73","author":"Li DQ","year":"2001","unstructured":"Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001 Oct; 73(4):449\u201359."},{"key":"B14","series-title":"Cornea.","first-page":"S24","article-title":"Expression of Wnt and MMP in epithelial cells during corneal wound healing","volume":"25","author":"Lyu J","year":"2006","unstructured":"Lyu J, Joo CK. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Cornea. 2006 Dec; 25(Suppl 1):S24\u20138."},{"issue":"1","key":"B15","series-title":"Jpn J Ophthalmol.","first-page":"92","article-title":"Expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells","volume":"62","author":"Iwatake A","year":"2018","unstructured":"Iwatake A, Murakami A, Ebihara N. Expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells. Jpn J Ophthalmol. 2018 Jan; 62(1):92\u2013100."},{"issue":"6","key":"B16","series-title":"Ophthalmic Res.","first-page":"315","article-title":"Inflammatory markers in the tears of patients with ocular surface disease","volume":"40","author":"Acera A","year":"2008","unstructured":"Acera A, Rocha G, Vecino E, Lema I, Dur\u00e1n JA. Inflammatory markers in the tears of patients with ocular surface disease. Ophthalmic Res. 2008; 40(6):315\u201321."},{"issue":"5","key":"B17","series-title":"Surv Ophthalmol.","first-page":"929","article-title":"Role of matrix metalloproteinases in infectious corneal ulcers","volume":"68","author":"Garc\u00eda-L\u00f3pez C","year":"2023","unstructured":"Garc\u00eda-L\u00f3pez C, Rodr\u00edguez-Calvo-de-Mora M, Borroni D, S\u00e1nchez-Gonz\u00e1lez JM, Romano V, Rocha-de-Lossada C. Role of matrix metalloproteinases in infectious corneal ulcers. Surv Ophthalmol. 2023 Sep; 68(5):929\u201339."},{"issue":"5","key":"B18","series-title":"Cornea.","first-page":"603","article-title":"Collagenolytic proteinases in keratoconus","volume":"25","author":"Mackiewicz Z","year":"2006","unstructured":"Mackiewicz Z, M\u00e4\u00e4tt\u00e4 M, Stenman M, Konttinen L, Tervo T, Konttinen YT. Collagenolytic proteinases in keratoconus. Cornea. 2006 Jun; 25(5):603\u201310."},{"issue":"2","key":"B19","series-title":"Invest Ophthalmol Vis Sci.","first-page":"404","article-title":"Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts","volume":"41","author":"Li DQ","year":"2000","unstructured":"Li DQ, Meller D, Liu Y, Tseng SC. Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):404\u201310."},{"issue":"4","key":"B20","series-title":"Exp Ther Med.","first-page":"3379","article-title":"Ocular cicatricial pemphigoid","volume":"20","author":"Branisteanu DC","year":"2020","unstructured":"Branisteanu DC, Stoleriu G, Branisteanu DE, Boda D, Branisteanu CI,  Ocular cicatricial pemphigoid. Exp Ther Med. 2020 Oct; 20(4):3379\u201382."},{"issue":"6","key":"B21","series-title":"Expert Opin Investig Drugs.","first-page":"797","article-title":"Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9","volume":"21","author":"Kowluru RA","year":"2012","unstructured":"Kowluru RA, Zhong Q, Santos JM. Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9. Expert Opin Investig Drugs. 2012 Jun; 21(6):797\u2013805."},{"issue":"1","key":"B22","series-title":"Prog Retin Eye Res.","first-page":"1","article-title":"MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology","volume":"21","author":"Sivak JM","year":"2002","unstructured":"Sivak JM, Fini ME. MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res. 2002 Jan; 21(1):1\u201322."},{"issue":"1","key":"B23","series-title":"NPJ Microgravity.","first-page":"1","article-title":"Ocular complaints and diagnoses in spaceflight","volume":"10","author":"Meer E","year":"2024","unstructured":"Meer E, Grob SR, Lehnhardt K, Sawyer A. Ocular complaints and diagnoses in spaceflight. NPJ Microgravity. 2024 Jan 2; 10(1):1."},{"issue":"3","key":"B24","series-title":"Jpn J Ophthalmol.","first-page":"256","article-title":"Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion","volume":"55","author":"Suzuki Y","year":"2011","unstructured":"Suzuki Y, Nakazawa M, Suzuki K, Yamazaki H, Miyagawa Y. Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Jpn J Ophthalmol. 2011 May; 55(3):256\u201363."},{"key":"B25","article-title":"One-carbon metabolism and SANS: 2022 update","author":"Smith SM","year":"2022","unstructured":"Smith SM, Bhatti MT, Chang AY, Chen JJ, Gibson CR,  One-carbon metabolism and SANS: 2022 update. Presented at: Human Research Program Investigators\u2019 Workshop [Virtual]; 2022 Feb 7; Galveston, TX. [Accessed 3 Nov. 2025]. Available from https:\/\/ntrs.nasa.gov\/citations\/20210022734."},{"key":"B26","series-title":"Spaceflight-associated neuro-ocular syndrome.","first-page":"55","article-title":"Genetics, vitamins, and spaceflight-associated neuro-ocular syndrome","author":"Zwart SR","year":"2022","unstructured":"Zwart SR, Smith SM. Genetics, vitamins, and spaceflight-associated neuro-ocular syndrome. In: Spaceflight-associated neuro-ocular syndrome. Cambridge (MA): Academic Press; 2022:55\u201365."},{"key":"B27","series-title":"Front Physiol.","first-page":"85","article-title":"Stress related shift toward inflammaging in cosmonauts after long-duration space flight","volume":"10","author":"Buchheim J-I","year":"2019","unstructured":"Buchheim J-I, Matzel S, Rykova M, Vassilieva G, Ponomarev S,  Stress related shift toward inflammaging in cosmonauts after long-duration space flight. Front Physiol. 2019 Feb 19; 10:85."},{"issue":"2","key":"B28","series-title":"Gravit Space Biol.","first-page":"1","article-title":"Changes in protein and gene expression of adhesion molecules and cytokines of endothelial cells immediately following short-term spaceflight travel","volume":"23","author":"Muid S","year":"2010","unstructured":"Muid S, Froemming GR, Manaf A, Muszaphar S, Yusoff K, Nawawi H. Changes in protein and gene expression of adhesion molecules and cytokines of endothelial cells immediately following short-term spaceflight travel. Gravit Space Biol. 2010 Sep; 23(2):1\u20138."},{"issue":"1","key":"B29","series-title":"Sci Rep.","first-page":"10469","article-title":"Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents","volume":"11","author":"Kwok AT","year":"2021","unstructured":"Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S,  Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469."},{"issue":"4","key":"B30","series-title":"Radiat Res.","first-page":"333","article-title":"Spaceflight-relevant challenges of radiation and\/or reduced weight bearing cause arthritic responses in knee articular cartilage","volume":"186","author":"Willey JS","year":"2016","unstructured":"Willey JS, Kwok AT, Moore JE, Payne V, Lindburg CA,  Spaceflight-relevant challenges of radiation and\/or reduced weight bearing cause arthritic responses in knee articular cartilage. Radiat Res. 2016 Oct; 186(4):333\u201344."},{"issue":"18","key":"B31","series-title":"Int J Mol Sci.","first-page":"10014","article-title":"Omics studies of specialized cells and stem cells under microgravity conditions","volume":"25","author":"Abdelfattah F","year":"2024","unstructured":"Abdelfattah F, Schulz H, Wehland M, Corydon TJ, Sahana J,  Omics studies of specialized cells and stem cells under microgravity conditions. Int J Mol Sci. 2024 Sep 17; 25(18):10014."},{"issue":"1","key":"B32","series-title":"NPJ Microgravity.","first-page":"41","article-title":"Spaceflight effects on human vascular smooth muscle cell phenotype and function","volume":"10","author":"Scotti MM","year":"2024","unstructured":"Scotti MM, Wilson BK, Bubenik JL, Yu F, Swanson MS, Allen JB. Spaceflight effects on human vascular smooth muscle cell phenotype and function. NPJ Microgravity. 2024 Mar 28; 10(1):41."},{"issue":"4","key":"B33","series-title":"PLoS One.","first-page":"e61372","article-title":"Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a\/p21","volume":"8","author":"Blaber EA","year":"2013","unstructured":"Blaber EA, Dvorochkin N, Lee C, Alwood JS, Yousuf R,  Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a\/p21. PLoS One. 2013 Apr 18; 8(4):e61372."},{"issue":"18","key":"B34","series-title":"Int J Mol Sci.","first-page":"13746","article-title":"Heterotypic cell culture from mouse bone marrow under simulated microgravity: lessons for stromal lineage functions","volume":"24","author":"Markina E","year":"2023","unstructured":"Markina E, Tyrina E, Ratushnyy A, Andreeva E, Buravkova L. Heterotypic cell culture from mouse bone marrow under simulated microgravity: lessons for stromal lineage functions. Int J Mol Sci. 2023 Sep 6; 24(18):13746."},{"key":"B35","series-title":"Bone.","first-page":"115152","article-title":"Multiscale effects of spaceflight on murine tendon and bone","volume":"131","author":"Deymier AC","year":"2020","unstructured":"Deymier AC, Schwartz AG, Lim C, Wingender B, Kotiya A,  Multiscale effects of spaceflight on murine tendon and bone. Bone. 2020 Feb; 131:115152."},{"issue":"1","key":"B36","series-title":"NPJ Microgravity.","first-page":"40","article-title":"Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice","volume":"9","author":"Emanuelsson EB","year":"2023","unstructured":"Emanuelsson EB, Baselet B, Neefs M, Baatout S, Proesmans B,  Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice. NPJ Microgravity. 2023 Jun 7; 9(1):40."},{"issue":"1","key":"B37","series-title":"Sci Rep.","first-page":"8215","article-title":"Characterization of mouse ocular response to a 35-day spaceflight mission: evidence of blood-retinal barrier disruption and ocular adaptations","volume":"9","author":"Mao XW","year":"2019","unstructured":"Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T,  Characterization of mouse ocular response to a 35-day spaceflight mission: evidence of blood-retinal barrier disruption and ocular adaptations. Sci Rep. 2019 Jun 3; 9(1):8215."},{"issue":"2","key":"B38","series-title":"J Appl Physiol (1985).","first-page":"641","article-title":"Hindlimb unloading depresses corneal epithelial wound healing in mice","volume":"97","author":"Li Z","year":"2004","unstructured":"Li Z, Rivera CA, Burns AR, Smith CW. Hindlimb unloading depresses corneal epithelial wound healing in mice. J Appl Physiol (1985). 2004 Aug; 97(2):641\u20137."},{"issue":"10","key":"B39","series-title":"JAMA Ophthalmol.","first-page":"1195","article-title":"Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest","volume":"137","author":"Zwart SR","year":"2019","unstructured":"Zwart SR, Laurie SS, Chen JJ, Macias BR, Lee SMC,  Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest. JAMA Ophthalmol. 2019 Oct; 137(10):1195\u2013200."},{"issue":"2","key":"B40","series-title":"Afr Vision Eye Health.","first-page":"100","article-title":"Tear biochemistry: a review","volume":"69","author":"Gillan WD.","year":"2010","unstructured":"Gillan WD. Tear biochemistry: a review. Afr Vision Eye Health. 2010 Dec; 69(2):100\u20136."},{"issue":"13","key":"B41","series-title":"Invest Ophthalmol Vis Sci.","first-page":"8285","article-title":"Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis","volume":"54","author":"Acera A","year":"2013","unstructured":"Acera A, Vecino E, Duran JA. Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. Invest Ophthalmol Vis Sci. 2013 Dec; 54(13):8285\u201391."},{"key":"B42","series-title":"Life Sci Space Res.","first-page":"53","article-title":"Molecular and biomechanical changes of the cornea and lens in spaceflight","volume":"38","author":"Panzo N","year":"2025","unstructured":"Panzo N, Memon H, Ong J, Suh A, Sampige R,  Molecular and biomechanical changes of the cornea and lens in spaceflight. Life Sci Space Res. 2025 Mar 15; 38:53\u201361."},{"issue":"6","key":"B43","series-title":"Arch Immunol Ther Exp (Warsz).","first-page":"419","article-title":"Effects of the initial treatment phase and adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in saliva and peripheral blood of patients with chronic periodontitis","volume":"54","author":"G\u00f3rska R","year":"2006","unstructured":"G\u00f3rska R, Nedzi-G\u00f3ra M. Effects of the initial treatment phase and adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in saliva and peripheral blood of patients with chronic periodontitis. Arch Immunol Ther Exp (Warsz). 2006 Dec; 54(6):419\u201326."},{"issue":"1","key":"B44","series-title":"J Periodontal Res.","first-page":"20","article-title":"Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis","volume":"39","author":"Choi DH","year":"2004","unstructured":"Choi DH, Moon IS, Choi BK, Paik JW, Kim YS,  Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis. J Periodontal Res. 2004 Feb; 39(1):20\u20136."},{"issue":"10","key":"B45","series-title":"Eye (Lond).","first-page":"1731","article-title":"Tear analysis as the next routine body fluid test","volume":"34","author":"Barmada A","year":"2020","unstructured":"Barmada A, Shippy SA. Tear analysis as the next routine body fluid test. Eye (Lond). 2020 Oct; 34(10):1731\u20133."},{"key":"B46","article-title":"Pilot study on the investigation of tear fluid biomarkers as an indicator of ocular, neurological, and immunological health in astronauts","author":"Morton S","year":"2018","unstructured":"Morton S, Crucian B, Hagan S, Satyamitra M, Daily A. Pilot study on the investigation of tear fluid biomarkers as an indicator of ocular, neurological, and immunological health in astronauts. Presented at: NASA Human Research Program Investigators\u2019 Workshop (HRP IWS 2018); 2018 Jan 22; Galveston, TX. Report No.: JSC-CN-40620. [Accessed 3 Nov. 2025]. Available from https:\/\/ntrs.nasa.gov\/citations\/20170010134."},{"issue":"1","key":"B47","series-title":"Ocul Immunol Inflamm.","first-page":"43","article-title":"Substance P level in tears as a potential biomarker for contact lens discomfort","volume":"29","author":"L\u00f3pez-de la Rosa A","year":"2021","unstructured":"L\u00f3pez-de la Rosa A, Garc\u00eda-V\u00e1zquez C, Fern\u00e1ndez I, Arroyo-Del Arroyo C, Enr\u00edquez-de-Salamanca A, Gonz\u00e1lez-Garc\u00eda MJ. Substance P level in tears as a potential biomarker for contact lens discomfort. Ocul Immunol Inflamm. 2021 Jan; 29(1):43\u201356."},{"key":"B48","series-title":"Biochem Biophys Res Commun.","first-page":"150744","article-title":"Ocular tear fluid biomarkers collected by contact lenses","volume":"734","author":"Boychev N","year":"2024","unstructured":"Boychev N, Yeung V, Yang M, Kanu LN, Ross AE,  Ocular tear fluid biomarkers collected by contact lenses. Biochem Biophys Res Commun. 2024 Nov 19; 734:150744."},{"issue":"10","key":"B49","series-title":"PLoS One.","first-page":"e0313027","article-title":"Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice","volume":"19","author":"Datta A","year":"2024","unstructured":"Datta A, Li XY, Nagpaul M. Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. PLoS One. 2024 Oct 31; 19(10):e0313027."},{"issue":"3","key":"B50","series-title":"Cesk Slov Oftalmol.","first-page":"122","article-title":"Modern biomarkers for early diagnosis of ocular surface disease in type 1 diabetes: a pilot study","volume":"81","author":"\u0160torm J","year":"2025","unstructured":"\u0160torm J, Burdov\u00e1 M\u010c, Uhl\u00edk J, Mina\u0159\u00edkov\u00e1 M, Lainov\u00e1 TV,  Modern biomarkers for early diagnosis of ocular surface disease in type 1 diabetes: a pilot study. Cesk Slov Oftalmol. 2025 Mar; 81(3):122\u20136."},{"issue":"7","key":"B51","series-title":"Transl Vis Sci Technol.","first-page":"9","article-title":"Tear fluid progranulin as a noninvasive biomarker for the monitoring of corneal innervation changes in patients with type 2 diabetes mellitus","volume":"13","author":"Zhou T","year":"2024","unstructured":"Zhou T, Dou Z, Cai Y, Zhu D, Fu Y. Tear fluid progranulin as a noninvasive biomarker for the monitoring of corneal innervation changes in patients with type 2 diabetes mellitus. Transl Vis Sci Technol. 2024 Jul 1; 13(7):9."},{"issue":"12","key":"B52","series-title":"Aviat Space Environ Med.","first-page":"1091","article-title":"Development of insulin resistance by astronauts during spaceflight","volume":"65","author":"Stein TP","year":"1994","unstructured":"Stein TP, Schulter MD, Boden G. Development of insulin resistance by astronauts during spaceflight. Aviat Space Environ Med. 1994 Dec; 65(12):1091\u20136."},{"issue":"12","key":"B53","series-title":"Eye (Lond).","first-page":"2409","article-title":"Spaceflight-associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development","volume":"37","author":"Ong J","year":"2023","unstructured":"Ong J, Mader TH, Gibson CR, Mason SS, Lee AG. Spaceflight-associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development. Eye (Lond). 2023 Aug; 37(12):2409\u201315."},{"issue":"3","key":"B54","series-title":"J Nutr.","first-page":"427","article-title":"Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism","volume":"142","author":"Zwart SR","year":"2012","unstructured":"Zwart SR, Gibson CR, Mader TH, Ericson K, Ploutz-Snyder R,  Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. J Nutr. 2012 Mar; 142(3):427\u201331."},{"issue":"1","key":"B55","series-title":"Biochem Biophys Res Commun.","first-page":"170","article-title":"Homocysteine modulates the proteolytic potential of human vascular endothelial cells","volume":"316","author":"Chaussalet M","year":"2004","unstructured":"Chaussalet M, Lamy E, Foucault-Bertaud A, Genovesio C, Sabatier F,  Homocysteine modulates the proteolytic potential of human vascular endothelial cells. Biochem Biophys Res Commun. 2004 Mar 26; 316(1):170\u20136."},{"issue":"1","key":"B56","series-title":"Epma J.","first-page":"1","article-title":"Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine","volume":"7","author":"Hagan S","year":"2016","unstructured":"Hagan S, Martin E, Enr\u00edquez-de-Salamanca A. Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine. Epma J. 2016 Dec; 7(1):1\u201320."},{"key":"B57","series-title":"A researcher\u2019s guide to: fruit fly research.","author":"Mains R","year":"2016","unstructured":"Mains R, Reynolds S, Lera M, Ellingson L. A researcher\u2019s guide to: fruit fly research. Houston (TX): NASA ISS Program Science Office; 2016 Nov."},{"key":"B58","series-title":"Human health and performance risks of space exploration missions.","first-page":"213","article-title":"Evidence report: risk of degenerative tissue or other health effects from radiation exposure","author":"Huff JL","year":"2013","unstructured":"Huff JL, Cucinotta FA. Evidence report: risk of degenerative tissue or other health effects from radiation exposure. In: McPhee J, Charles J, editors. Human health and performance risks of space exploration missions. Houston (TX): NASA Johnson Space Center; 2013:213\u201335."},{"issue":"3","key":"B59","series-title":"Life (Basel).","first-page":"491","article-title":"Space radiation: the number one risk to astronaut health beyond low Earth orbit","volume":"4","author":"Chancellor JC","year":"2014","unstructured":"Chancellor JC, Scott GB, Sutton JP. Space radiation: the number one risk to astronaut health beyond low Earth orbit. Life (Basel). 2014 Sep; 4(3):491\u2013510."},{"issue":"1","key":"B1","series-title":"NPJ Microgravity.","first-page":"37","article-title":"Ocular conditions and injuries, detection and management in spaceflight","volume":"9","author":"Meer E","year":"2023","unstructured":"Meer E, Grob S, Antonsen EL, Sawyer A. Ocular conditions and injuries, detection and management in spaceflight. NPJ Microgravity. 2023 May 16; 9(1):37."},{"issue":"9","key":"B2","series-title":"JAMA Ophthalmol.","first-page":"808","article-title":"Severe spaceflight-associated neuro-ocular syndrome in an astronaut with 2 predisposing factors","volume":"142","author":"Brunstetter TJ","year":"2024","unstructured":"Brunstetter TJ, Zwart SR, Brandt K, Brown DM, Clemett SJ,  Severe spaceflight-associated neuro-ocular syndrome in an astronaut with 2 predisposing factors. JAMA Ophthalmol. 2024 Sep 1; 142(9):808\u201317."},{"issue":"5","key":"B3","series-title":"JAMA Ophthalmol.","first-page":"553","article-title":"Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery","volume":"138","author":"Macias BR","year":"2020","unstructured":"Macias BR, Patel NB, Gibson CR, Samuels BC, Laurie SS,  Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery. JAMA Ophthalmol. 2020 May 1; 138(5):553\u20139."},{"issue":"3","key":"B4","series-title":"Biomedicine & Aging Pathology.","first-page":"97","article-title":"Metalloproteinases and eye diseases","volume":"3","author":"Pescosolido N","year":"2013","unstructured":"Pescosolido N, Giannotti R, Buomprisco G. Metalloproteinases and eye diseases. Biomedicine & Aging Pathology. 2013 Jul-Sep; 3(3):97\u2013105."},{"issue":"3","key":"B5","series-title":"Ocul Surf.","first-page":"276","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig JP","year":"2017","unstructured":"Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS,  TFOS DEWS II definition and classification report. Ocul Surf. 2017 Jul; 15(3):276\u201383."},{"key":"B6","series-title":"Exp Eye Res.","first-page":"108523","article-title":"Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome: a review study","volume":"205","author":"Shoari A","year":"2021","unstructured":"Shoari A, Kanavi MR, Rasaee MJ. Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome: a review study. Exp Eye Res. 2021 Apr; 205:108523."},{"key":"B7","article-title":"Background: preflight screening, in-flight capabilities, and postflight testing","author":"Gibson CR","year":"2009","unstructured":"Gibson CR, Duncan J. Background: preflight screening, in-flight capabilities, and postflight testing. Houston (TX): NASA Johnson Space Center; 2009 Jul 27. Report No.: JSC-CN-18652."},{"key":"B8","series-title":"Space physiology and medicine.","first-page":"245","article-title":"Neurology","author":"Reschke MF","year":"2016","unstructured":"Reschke MF, Cl\u00e9ment G, Thorson SL, Harm DL, Mader TH,  Neurology. In: Nicogossian A, Williams R, Huntoon C, Doarn C, Polk J, Scheider V, editors. Space physiology and medicine. New York (NY): Springer; 2016:245\u201382."},{"issue":"1","key":"B9","series-title":"J Neuroophthalmol.","first-page":"84","article-title":"Origins of cerebral edema: implications for spaceflight-associated neuro-ocular syndrome","volume":"40","author":"Galdamez LA","year":"2020","unstructured":"Galdamez LA, Brunstetter TJ, Lee AG, Tarver WJ. Origins of cerebral edema: implications for spaceflight-associated neuro-ocular syndrome. J Neuroophthalmol. 2020 Mar; 40(1):84\u201391."},{"issue":"4","key":"B10","series-title":"Curr Opin Chem Biol.","first-page":"466","article-title":"Matrix metalloproteinases","volume":"2","author":"Johnson LL","year":"1998","unstructured":"Johnson LL, Dyer R, Hupe DJ. Matrix metalloproteinases. Curr Opin Chem Biol. 1998 Aug; 2(4):466\u201371."},{"key":"B11","series-title":"Zinc metalloproteases in health and disease.","first-page":"173","article-title":"Matrix metalloproteinases","author":"Nagase H.","year":"1996","unstructured":"Nagase H. Matrix metalloproteinases. In: Zinc metalloproteases in health and disease. London: Taylor & Francis; 1996 Jul 30:173\u2013224."},{"key":"B12","series-title":"Int Immunopharmacol.","first-page":"105812","article-title":"Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients","volume":"77","author":"Ghasemi H","year":"2019","unstructured":"Ghasemi H, Yaraee R, Faghihzadeh S, Ghassemi-Broumand M, Mahmoudi M,  Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients. Int Immunopharmacol. 2019 Dec; 77:105812."},{"issue":"4","key":"B13","series-title":"Exp Eye Res.","first-page":"449","article-title":"Regulation of MMP-9 production by human corneal epithelial cells","volume":"73","author":"Li DQ","year":"2001","unstructured":"Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001 Oct; 73(4):449\u201359."},{"key":"B14","series-title":"Cornea.","first-page":"S24","article-title":"Expression of Wnt and MMP in epithelial cells during corneal wound healing","volume":"25","author":"Lyu J","year":"2006","unstructured":"Lyu J, Joo CK. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Cornea. 2006 Dec; 25(Suppl 1):S24\u20138."},{"issue":"1","key":"B15","series-title":"Jpn J Ophthalmol.","first-page":"92","article-title":"Expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells","volume":"62","author":"Iwatake A","year":"2018","unstructured":"Iwatake A, Murakami A, Ebihara N. Expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells. Jpn J Ophthalmol. 2018 Jan; 62(1):92\u2013100."},{"issue":"6","key":"B16","series-title":"Ophthalmic Res.","first-page":"315","article-title":"Inflammatory markers in the tears of patients with ocular surface disease","volume":"40","author":"Acera A","year":"2008","unstructured":"Acera A, Rocha G, Vecino E, Lema I, Dur\u00e1n JA. Inflammatory markers in the tears of patients with ocular surface disease. Ophthalmic Res. 2008; 40(6):315\u201321."},{"issue":"5","key":"B17","series-title":"Surv Ophthalmol.","first-page":"929","article-title":"Role of matrix metalloproteinases in infectious corneal ulcers","volume":"68","author":"Garc\u00eda-L\u00f3pez C","year":"2023","unstructured":"Garc\u00eda-L\u00f3pez C, Rodr\u00edguez-Calvo-de-Mora M, Borroni D, S\u00e1nchez-Gonz\u00e1lez JM, Romano V, Rocha-de-Lossada C. Role of matrix metalloproteinases in infectious corneal ulcers. Surv Ophthalmol. 2023 Sep; 68(5):929\u201339."},{"issue":"5","key":"B18","series-title":"Cornea.","first-page":"603","article-title":"Collagenolytic proteinases in keratoconus","volume":"25","author":"Mackiewicz Z","year":"2006","unstructured":"Mackiewicz Z, M\u00e4\u00e4tt\u00e4 M, Stenman M, Konttinen L, Tervo T, Konttinen YT. Collagenolytic proteinases in keratoconus. Cornea. 2006 Jun; 25(5):603\u201310."},{"issue":"2","key":"B19","series-title":"Invest Ophthalmol Vis Sci.","first-page":"404","article-title":"Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts","volume":"41","author":"Li DQ","year":"2000","unstructured":"Li DQ, Meller D, Liu Y, Tseng SC. Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):404\u201310."},{"issue":"4","key":"B20","series-title":"Exp Ther Med.","first-page":"3379","article-title":"Ocular cicatricial pemphigoid","volume":"20","author":"Branisteanu DC","year":"2020","unstructured":"Branisteanu DC, Stoleriu G, Branisteanu DE, Boda D, Branisteanu CI,  Ocular cicatricial pemphigoid. Exp Ther Med. 2020 Oct; 20(4):3379\u201382."},{"issue":"6","key":"B21","series-title":"Expert Opin Investig Drugs.","first-page":"797","article-title":"Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9","volume":"21","author":"Kowluru RA","year":"2012","unstructured":"Kowluru RA, Zhong Q, Santos JM. Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9. Expert Opin Investig Drugs. 2012 Jun; 21(6):797\u2013805."},{"issue":"1","key":"B22","series-title":"Prog Retin Eye Res.","first-page":"1","article-title":"MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology","volume":"21","author":"Sivak JM","year":"2002","unstructured":"Sivak JM, Fini ME. MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res. 2002 Jan; 21(1):1\u201322."},{"issue":"1","key":"B23","series-title":"NPJ Microgravity.","first-page":"1","article-title":"Ocular complaints and diagnoses in spaceflight","volume":"10","author":"Meer E","year":"2024","unstructured":"Meer E, Grob SR, Lehnhardt K, Sawyer A. Ocular complaints and diagnoses in spaceflight. NPJ Microgravity. 2024 Jan 2; 10(1):1."},{"issue":"3","key":"B24","series-title":"Jpn J Ophthalmol.","first-page":"256","article-title":"Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion","volume":"55","author":"Suzuki Y","year":"2011","unstructured":"Suzuki Y, Nakazawa M, Suzuki K, Yamazaki H, Miyagawa Y. Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Jpn J Ophthalmol. 2011 May; 55(3):256\u201363."},{"key":"B25","article-title":"One-carbon metabolism and SANS: 2022 update","author":"Smith SM","year":"2022","unstructured":"Smith SM, Bhatti MT, Chang AY, Chen JJ, Gibson CR,  One-carbon metabolism and SANS: 2022 update. Presented at: Human Research Program Investigators\u2019 Workshop [Virtual]; 2022 Feb 7; Galveston, TX. [Accessed 3 Nov. 2025]. Available from https:\/\/ntrs.nasa.gov\/citations\/20210022734."},{"key":"B26","series-title":"Spaceflight-associated neuro-ocular syndrome.","first-page":"55","article-title":"Genetics, vitamins, and spaceflight-associated neuro-ocular syndrome","author":"Zwart SR","year":"2022","unstructured":"Zwart SR, Smith SM. Genetics, vitamins, and spaceflight-associated neuro-ocular syndrome. In: Spaceflight-associated neuro-ocular syndrome. Cambridge (MA): Academic Press; 2022:55\u201365."},{"key":"B27","series-title":"Front Physiol.","first-page":"85","article-title":"Stress related shift toward inflammaging in cosmonauts after long-duration space flight","volume":"10","author":"Buchheim J-I","year":"2019","unstructured":"Buchheim J-I, Matzel S, Rykova M, Vassilieva G, Ponomarev S,  Stress related shift toward inflammaging in cosmonauts after long-duration space flight. Front Physiol. 2019 Feb 19; 10:85."},{"issue":"2","key":"B28","series-title":"Gravit Space Biol.","first-page":"1","article-title":"Changes in protein and gene expression of adhesion molecules and cytokines of endothelial cells immediately following short-term spaceflight travel","volume":"23","author":"Muid S","year":"2010","unstructured":"Muid S, Froemming GR, Manaf A, Muszaphar S, Yusoff K, Nawawi H. Changes in protein and gene expression of adhesion molecules and cytokines of endothelial cells immediately following short-term spaceflight travel. Gravit Space Biol. 2010 Sep; 23(2):1\u20138."},{"issue":"1","key":"B29","series-title":"Sci Rep.","first-page":"10469","article-title":"Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents","volume":"11","author":"Kwok AT","year":"2021","unstructured":"Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S,  Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469."},{"issue":"4","key":"B30","series-title":"Radiat Res.","first-page":"333","article-title":"Spaceflight-relevant challenges of radiation and\/or reduced weight bearing cause arthritic responses in knee articular cartilage","volume":"186","author":"Willey JS","year":"2016","unstructured":"Willey JS, Kwok AT, Moore JE, Payne V, Lindburg CA,  Spaceflight-relevant challenges of radiation and\/or reduced weight bearing cause arthritic responses in knee articular cartilage. Radiat Res. 2016 Oct; 186(4):333\u201344."},{"issue":"18","key":"B31","series-title":"Int J Mol Sci.","first-page":"10014","article-title":"Omics studies of specialized cells and stem cells under microgravity conditions","volume":"25","author":"Abdelfattah F","year":"2024","unstructured":"Abdelfattah F, Schulz H, Wehland M, Corydon TJ, Sahana J,  Omics studies of specialized cells and stem cells under microgravity conditions. Int J Mol Sci. 2024 Sep 17; 25(18):10014."},{"issue":"1","key":"B32","series-title":"NPJ Microgravity.","first-page":"41","article-title":"Spaceflight effects on human vascular smooth muscle cell phenotype and function","volume":"10","author":"Scotti MM","year":"2024","unstructured":"Scotti MM, Wilson BK, Bubenik JL, Yu F, Swanson MS, Allen JB. Spaceflight effects on human vascular smooth muscle cell phenotype and function. NPJ Microgravity. 2024 Mar 28; 10(1):41."},{"issue":"4","key":"B33","series-title":"PLoS One.","first-page":"e61372","article-title":"Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a\/p21","volume":"8","author":"Blaber EA","year":"2013","unstructured":"Blaber EA, Dvorochkin N, Lee C, Alwood JS, Yousuf R,  Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a\/p21. PLoS One. 2013 Apr 18; 8(4):e61372."},{"issue":"18","key":"B34","series-title":"Int J Mol Sci.","first-page":"13746","article-title":"Heterotypic cell culture from mouse bone marrow under simulated microgravity: lessons for stromal lineage functions","volume":"24","author":"Markina E","year":"2023","unstructured":"Markina E, Tyrina E, Ratushnyy A, Andreeva E, Buravkova L. Heterotypic cell culture from mouse bone marrow under simulated microgravity: lessons for stromal lineage functions. Int J Mol Sci. 2023 Sep 6; 24(18):13746."},{"key":"B35","series-title":"Bone.","first-page":"115152","article-title":"Multiscale effects of spaceflight on murine tendon and bone","volume":"131","author":"Deymier AC","year":"2020","unstructured":"Deymier AC, Schwartz AG, Lim C, Wingender B, Kotiya A,  Multiscale effects of spaceflight on murine tendon and bone. Bone. 2020 Feb; 131:115152."},{"issue":"1","key":"B36","series-title":"NPJ Microgravity.","first-page":"40","article-title":"Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice","volume":"9","author":"Emanuelsson EB","year":"2023","unstructured":"Emanuelsson EB, Baselet B, Neefs M, Baatout S, Proesmans B,  Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice. NPJ Microgravity. 2023 Jun 7; 9(1):40."},{"issue":"1","key":"B37","series-title":"Sci Rep.","first-page":"8215","article-title":"Characterization of mouse ocular response to a 35-day spaceflight mission: evidence of blood-retinal barrier disruption and ocular adaptations","volume":"9","author":"Mao XW","year":"2019","unstructured":"Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T,  Characterization of mouse ocular response to a 35-day spaceflight mission: evidence of blood-retinal barrier disruption and ocular adaptations. Sci Rep. 2019 Jun 3; 9(1):8215."},{"issue":"2","key":"B38","series-title":"J Appl Physiol (1985).","first-page":"641","article-title":"Hindlimb unloading depresses corneal epithelial wound healing in mice","volume":"97","author":"Li Z","year":"2004","unstructured":"Li Z, Rivera CA, Burns AR, Smith CW. Hindlimb unloading depresses corneal epithelial wound healing in mice. J Appl Physiol (1985). 2004 Aug; 97(2):641\u20137."},{"issue":"10","key":"B39","series-title":"JAMA Ophthalmol.","first-page":"1195","article-title":"Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest","volume":"137","author":"Zwart SR","year":"2019","unstructured":"Zwart SR, Laurie SS, Chen JJ, Macias BR, Lee SMC,  Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest. JAMA Ophthalmol. 2019 Oct; 137(10):1195\u2013200."},{"issue":"2","key":"B40","series-title":"Afr Vision Eye Health.","first-page":"100","article-title":"Tear biochemistry: a review","volume":"69","author":"Gillan WD.","year":"2010","unstructured":"Gillan WD. Tear biochemistry: a review. Afr Vision Eye Health. 2010 Dec; 69(2):100\u20136."},{"issue":"13","key":"B41","series-title":"Invest Ophthalmol Vis Sci.","first-page":"8285","article-title":"Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis","volume":"54","author":"Acera A","year":"2013","unstructured":"Acera A, Vecino E, Duran JA. Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. Invest Ophthalmol Vis Sci. 2013 Dec; 54(13):8285\u201391."},{"key":"B42","series-title":"Life Sci Space Res.","first-page":"53","article-title":"Molecular and biomechanical changes of the cornea and lens in spaceflight","volume":"38","author":"Panzo N","year":"2025","unstructured":"Panzo N, Memon H, Ong J, Suh A, Sampige R,  Molecular and biomechanical changes of the cornea and lens in spaceflight. Life Sci Space Res. 2025 Mar 15; 38:53\u201361."},{"issue":"6","key":"B43","series-title":"Arch Immunol Ther Exp (Warsz).","first-page":"419","article-title":"Effects of the initial treatment phase and adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in saliva and peripheral blood of patients with chronic periodontitis","volume":"54","author":"G\u00f3rska R","year":"2006","unstructured":"G\u00f3rska R, Nedzi-G\u00f3ra M. Effects of the initial treatment phase and adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in saliva and peripheral blood of patients with chronic periodontitis. Arch Immunol Ther Exp (Warsz). 2006 Dec; 54(6):419\u201326."},{"issue":"1","key":"B44","series-title":"J Periodontal Res.","first-page":"20","article-title":"Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis","volume":"39","author":"Choi DH","year":"2004","unstructured":"Choi DH, Moon IS, Choi BK, Paik JW, Kim YS,  Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis. J Periodontal Res. 2004 Feb; 39(1):20\u20136."},{"issue":"10","key":"B45","series-title":"Eye (Lond).","first-page":"1731","article-title":"Tear analysis as the next routine body fluid test","volume":"34","author":"Barmada A","year":"2020","unstructured":"Barmada A, Shippy SA. Tear analysis as the next routine body fluid test. Eye (Lond). 2020 Oct; 34(10):1731\u20133."},{"key":"B46","article-title":"Pilot study on the investigation of tear fluid biomarkers as an indicator of ocular, neurological, and immunological health in astronauts","author":"Morton S","year":"2018","unstructured":"Morton S, Crucian B, Hagan S, Satyamitra M, Daily A. Pilot study on the investigation of tear fluid biomarkers as an indicator of ocular, neurological, and immunological health in astronauts. Presented at: NASA Human Research Program Investigators\u2019 Workshop (HRP IWS 2018); 2018 Jan 22; Galveston, TX. Report No.: JSC-CN-40620. [Accessed 3 Nov. 2025]. Available from https:\/\/ntrs.nasa.gov\/citations\/20170010134."},{"issue":"1","key":"B47","series-title":"Ocul Immunol Inflamm.","first-page":"43","article-title":"Substance P level in tears as a potential biomarker for contact lens discomfort","volume":"29","author":"L\u00f3pez-de la Rosa A","year":"2021","unstructured":"L\u00f3pez-de la Rosa A, Garc\u00eda-V\u00e1zquez C, Fern\u00e1ndez I, Arroyo-Del Arroyo C, Enr\u00edquez-de-Salamanca A, Gonz\u00e1lez-Garc\u00eda MJ. Substance P level in tears as a potential biomarker for contact lens discomfort. Ocul Immunol Inflamm. 2021 Jan; 29(1):43\u201356."},{"key":"B48","series-title":"Biochem Biophys Res Commun.","first-page":"150744","article-title":"Ocular tear fluid biomarkers collected by contact lenses","volume":"734","author":"Boychev N","year":"2024","unstructured":"Boychev N, Yeung V, Yang M, Kanu LN, Ross AE,  Ocular tear fluid biomarkers collected by contact lenses. Biochem Biophys Res Commun. 2024 Nov 19; 734:150744."},{"issue":"10","key":"B49","series-title":"PLoS One.","first-page":"e0313027","article-title":"Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice","volume":"19","author":"Datta A","year":"2024","unstructured":"Datta A, Li XY, Nagpaul M. Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. PLoS One. 2024 Oct 31; 19(10):e0313027."},{"issue":"3","key":"B50","series-title":"Cesk Slov Oftalmol.","first-page":"122","article-title":"Modern biomarkers for early diagnosis of ocular surface disease in type 1 diabetes: a pilot study","volume":"81","author":"\u0160torm J","year":"2025","unstructured":"\u0160torm J, Burdov\u00e1 M\u010c, Uhl\u00edk J, Mina\u0159\u00edkov\u00e1 M, Lainov\u00e1 TV,  Modern biomarkers for early diagnosis of ocular surface disease in type 1 diabetes: a pilot study. Cesk Slov Oftalmol. 2025 Mar; 81(3):122\u20136."},{"issue":"7","key":"B51","series-title":"Transl Vis Sci Technol.","first-page":"9","article-title":"Tear fluid progranulin as a noninvasive biomarker for the monitoring of corneal innervation changes in patients with type 2 diabetes mellitus","volume":"13","author":"Zhou T","year":"2024","unstructured":"Zhou T, Dou Z, Cai Y, Zhu D, Fu Y. Tear fluid progranulin as a noninvasive biomarker for the monitoring of corneal innervation changes in patients with type 2 diabetes mellitus. Transl Vis Sci Technol. 2024 Jul 1; 13(7):9."},{"issue":"12","key":"B52","series-title":"Aviat Space Environ Med.","first-page":"1091","article-title":"Development of insulin resistance by astronauts during spaceflight","volume":"65","author":"Stein TP","year":"1994","unstructured":"Stein TP, Schulter MD, Boden G. Development of insulin resistance by astronauts during spaceflight. Aviat Space Environ Med. 1994 Dec; 65(12):1091\u20136."},{"issue":"12","key":"B53","series-title":"Eye (Lond).","first-page":"2409","article-title":"Spaceflight-associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development","volume":"37","author":"Ong J","year":"2023","unstructured":"Ong J, Mader TH, Gibson CR, Mason SS, Lee AG. Spaceflight-associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development. Eye (Lond). 2023 Aug; 37(12):2409\u201315."},{"issue":"3","key":"B54","series-title":"J Nutr.","first-page":"427","article-title":"Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism","volume":"142","author":"Zwart SR","year":"2012","unstructured":"Zwart SR, Gibson CR, Mader TH, Ericson K, Ploutz-Snyder R,  Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. J Nutr. 2012 Mar; 142(3):427\u201331."},{"issue":"1","key":"B55","series-title":"Biochem Biophys Res Commun.","first-page":"170","article-title":"Homocysteine modulates the proteolytic potential of human vascular endothelial cells","volume":"316","author":"Chaussalet M","year":"2004","unstructured":"Chaussalet M, Lamy E, Foucault-Bertaud A, Genovesio C, Sabatier F,  Homocysteine modulates the proteolytic potential of human vascular endothelial cells. Biochem Biophys Res Commun. 2004 Mar 26; 316(1):170\u20136."},{"issue":"1","key":"B56","series-title":"Epma J.","first-page":"1","article-title":"Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine","volume":"7","author":"Hagan S","year":"2016","unstructured":"Hagan S, Martin E, Enr\u00edquez-de-Salamanca A. Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine. Epma J. 2016 Dec; 7(1):1\u201320."},{"key":"B57","series-title":"A researcher\u2019s guide to: fruit fly research.","author":"Mains R","year":"2016","unstructured":"Mains R, Reynolds S, Lera M, Ellingson L. A researcher\u2019s guide to: fruit fly research. Houston (TX): NASA ISS Program Science Office; 2016 Nov."},{"key":"B58","series-title":"Human health and performance risks of space exploration missions.","first-page":"213","article-title":"Evidence report: risk of degenerative tissue or other health effects from radiation exposure","author":"Huff JL","year":"2013","unstructured":"Huff JL, Cucinotta FA. Evidence report: risk of degenerative tissue or other health effects from radiation exposure. In: McPhee J, Charles J, editors. Human health and performance risks of space exploration missions. Houston (TX): NASA Johnson Space Center; 2013:213\u201335."},{"issue":"3","key":"B59","series-title":"Life (Basel).","first-page":"491","article-title":"Space radiation: the number one risk to astronaut health beyond low Earth orbit","volume":"4","author":"Chancellor JC","year":"2014","unstructured":"Chancellor JC, Scott GB, Sutton JP. Space radiation: the number one risk to astronaut health beyond low Earth orbit. Life (Basel). 2014 Sep; 4(3):491\u2013510."}],"container-title":["Aerospace Medicine and Human Performance"],"original-title":[],"link":[{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/97\/1\/article-p47.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/97\/1\/article-p47.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/97\/1\/article-p47.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:59:00Z","timestamp":1777082340000},"score":1,"resource":{"primary":{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/97\/1\/article-p47.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":118,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3357\/amhp.6730.2026","relation":{},"ISSN":["2375-6314","2375-6322"],"issn-type":[{"value":"2375-6314","type":"print"},{"value":"2375-6322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}