{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:38:02Z","timestamp":1777343882753,"version":"3.51.4"},"reference-count":92,"publisher":"Aerospace Medical Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>INTRODUCTION:<\/jats:bold>\n                    Long-duration space missions pose a risk to visual health due to cephalad fluid shifts in microgravity; this can affect ocular structures, causing decreased astronaut performance in addition to long-term side effects. Understanding these changes is essential for developing effective countermeasures against spaceflight-associated neuro-ocular syndrome. We reviewed how head-down tilt (HDT)\u2014a terrestrial analog of microgravity\u2014affects ocular parameters measured by optical coherence tomography (OCT) and intraocular pressure (IOP).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    Seven databases were searched through May 2025 for studies involving human subjects undergoing HDT at any angle or duration with OCT-based outcomes: total retinal thickness (TRT), retinal nerve fiber layer thickness (RNFLT), and choroidal thickness. Two reviewers extracted data and assessed risk of bias using ROBINS-I v2.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    There were 11 studies (133 subjects\n                    <jats:bold>)<\/jats:bold>\n                    which met inclusion criteria. Mild HDT (\u223c6\u00b0) caused moderate IOP elevation (+2\u20134 mmHg) and slight TRT thickening over several days. Prolonged HDT (15\u201365 d) produced cumulative TRT (+35\u201354 \u00b5m) and RNFLT (+2\u20137 \u00b5m) increases, with occasional choroidal folds. Steeper tilts (\u201310\u00b0 to \u201315\u00b0) triggered rapid IOP rises (up to +7 mmHg) and acute choroidal thickness changes. Post-HDT recovery was often incomplete, with delayed normalization of TRT and RNFLT.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DISCUSSION:<\/jats:bold>\n                    HDT-induced changes in IOP and OCT parameters support the role of cephalad fluid shifts in disrupting cranial venous outflow and causing ocular structural changes. Future research should standardize methodology with longer follow-up periods to improve the translational relevance of findings to spaceflight-associated neuro-ocular syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      Roshdy MR, Botros M, Mokhles A, Matwiejuk W, Keriakos AR.\n                      <jats:italic>Microgravity-induced ocular changes assessed by optical coherence tomography<\/jats:italic>\n                      . Aerosp Med Hum Perform. 2026; 97(5):362\u2013371.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.3357\/amhp.6777.2026","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:02Z","timestamp":1777341542000},"page":"362-371","source":"Crossref","is-referenced-by-count":0,"title":["Microgravity-Induced Ocular Changes Assessed by Optical Coherence Tomography"],"prefix":"10.3357","volume":"97","author":[{"given":"Merna Raafat","family":"Roshdy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Botros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abanoub","family":"Mokhles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weronika","family":"Matwiejuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia R.","family":"Keriakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1911","reference":[{"issue":"10","key":"B1","series-title":"Ophthalmology.","first-page":"2058","article-title":"Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight","volume":"118","author":"Mader TH","year":"2011","unstructured":"Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG,  Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011 Oct; 118(10):2058\u201369."},{"key":"B2","series-title":"Front Neurol.","first-page":"648958","article-title":"Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome","volume":"12","author":"Ong J","year":"2021","unstructured":"Ong J, Lee AG, Moss HE. Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome. Front Neurol. 2021 Mar 26; 12:648958."},{"key":"B3","series-title":"NPJ Microgravity.","first-page":"7","article-title":"Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update","volume":"6","author":"Lee AG","year":"2020","unstructured":"Lee AG, Mader TH, Gibson CR, Tarver W, Rabiei P,  Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update. NPJ Microgravity. 2020 Feb 7; 6:7."},{"issue":"7","key":"B4","series-title":"Br J Ophthalmol.","first-page":"895","article-title":"Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures","volume":"107","author":"Ong J","year":"2023","unstructured":"Ong J, Tarver W, Brunstetter T, Mader TH, Gibson CR,  Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures. Br J Ophthalmol. 2023 Jul; 107(7):895\u2013900."},{"issue":"2","key":"B5","series-title":"J Neuroophthalmol.","first-page":"133","article-title":"Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis","volume":"37","author":"Mader TH","year":"2017","unstructured":"Mader TH, Gibson CR, Otto CA, Sargsyan AE, Miller NR,  Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis. J Neuroophthalmol. 2017 Jun; 37(2):133\u20139."},{"issue":"1","key":"B6","series-title":"Neuroophthalmology.","first-page":"29","article-title":"Persistent globe flattening in astronauts following long-duration spaceflight","volume":"45","author":"Mader TH","year":"2020","unstructured":"Mader TH, Gibson CR, Barratt MR, Miller NR, Subramanian PS,  Persistent globe flattening in astronauts following long-duration spaceflight. Neuroophthalmology. 2020 Sep 3; 45(1):29\u201335."},{"issue":"4","key":"B7","series-title":"Life (Basel).","first-page":"621","article-title":"Microgravity-induced fluid shift and ophthalmic changes","volume":"4","author":"Nelson ES","year":"2014","unstructured":"Nelson ES, Mulugeta L, Myers JG. Microgravity-induced fluid shift and ophthalmic changes. Life (Basel). 2014 Nov 7; 4(4):621\u201365."},{"issue":"1","key":"B8","series-title":"J Magn Reson Imaging.","first-page":"206","article-title":"Role of the spinal canal compliance in regulating posture-related cerebrospinal fluid hydrodynamics in humans","volume":"54","author":"Alperin N","year":"2021","unstructured":"Alperin N, Burman R, Lee SH. Role of the spinal canal compliance in regulating posture-related cerebrospinal fluid hydrodynamics in humans. J Magn Reson Imaging. 2021 Jul; 54(1):206\u201314."},{"issue":"5","key":"B9","series-title":"JAMA Ophthalmol.","first-page":"553","article-title":"Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery","volume":"138","author":"Macias BR","year":"2020","unstructured":"Macias BR, Patel NB, Gibson CR, Samuels BC, Laurie SS,  Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery. JAMA Ophthalmol. 2020 May 1; 138(5):553\u20139."},{"issue":"10","key":"B10","series-title":"Aviat Space Environ Med.","first-page":"983","article-title":"Ocular outcomes evaluation in a 14-day head-down bed rest study","volume":"85","author":"Taibbi G","year":"2014","unstructured":"Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ,  Ocular outcomes evaluation in a 14-day head-down bed rest study. Aviat Space Environ Med. 2014 Oct; 85(10):983\u201392."},{"issue":"15","key":"B11","series-title":"Physiol Rep.","first-page":"e14977","article-title":"Optic disc edema and chorioretinal folds develop during strict 6\u00b0 head-down tilt bed rest with or without artificial gravity","volume":"9","author":"Laurie SS","year":"2021","unstructured":"Laurie SS, Greenwald SH, Marshall-Goebel K, Pardon LP, Gupta A,  Optic disc edema and chorioretinal folds develop during strict 6\u00b0 head-down tilt bed rest with or without artificial gravity. Physiol Rep. 2021 Aug; 9(15):e14977."},{"issue":"2","key":"B12","series-title":"JAMA Ophthalmol.","first-page":"193","article-title":"Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station astronauts","volume":"136","author":"Patel N","year":"2018","unstructured":"Patel N, Pass A, Mason S, Gibson CR, Otto C. Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station astronauts. JAMA Ophthalmol. 2018 Feb 1; 136(2):193\u2013200."},{"issue":"1","key":"B13","series-title":"Fluids Barriers CNS.","first-page":"85","article-title":"Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension","volume":"19","author":"Mitchell JL","year":"2022","unstructured":"Mitchell JL, Buckham R, Lyons H, Walker JK, Yiangou A,  Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension. Fluids Barriers CNS. 2022 Nov 1; 19(1):85."},{"issue":"3","key":"B14","series-title":"J Glaucoma.","first-page":"255","article-title":"Head-down posture induces PERG alterations in early glaucoma","volume":"22","author":"Ventura LM","year":"2013","unstructured":"Ventura LM, Golubev I, Lee W, Nose I, Parel J-M,  Head-down posture induces PERG alterations in early glaucoma. J Glaucoma. 2013 Mar; 22(3):255\u201364."},{"issue":"8","key":"B15","series-title":"J Ocul Pharmacol Ther.","first-page":"598","article-title":"The effect of posture on intraocular pressure and systemic hemodynamic parameters in treated and untreated patients with primary open-angle glaucoma","volume":"33","author":"Katsanos A","year":"2017","unstructured":"Katsanos A, Dastiridou AI, Quaranta L, Rulli E, Riva I,  The effect of posture on intraocular pressure and systemic hemodynamic parameters in treated and untreated patients with primary open-angle glaucoma. J Ocul Pharmacol Ther. 2017 Oct; 33(8):598\u2013603."},{"issue":"7","key":"B16","series-title":"Aerosp Med Hum Perform.","first-page":"633","article-title":"Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest","volume":"88","author":"Taibbi G","year":"2017","unstructured":"Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ,  Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest. Aerosp Med Hum Perform. 2017 Jul 1; 88(7):633\u201340."},{"issue":"3","key":"B17","series-title":"Rev Lat Am Enfermagem.","first-page":"508","article-title":"The PICO strategy for the research question construction and evidence search","volume":"15","author":"da Costa Santos CM","year":"2007","unstructured":"da Costa Santos CM, de Mattos Pimenta CA, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007 Jun; 15(3):508\u201311."},{"issue":"3","key":"B18","series-title":"Transl Vis Sci Technol.","first-page":"17","article-title":"Repeatability of adaptive optics automated cone measurements in subjects with retinitis pigmentosa and novel metrics for assessment of image quality","volume":"8","author":"Gale MJ","year":"2019","unstructured":"Gale MJ, Harman GA, Chen J, Pennesi ME. Repeatability of adaptive optics automated cone measurements in subjects with retinitis pigmentosa and novel metrics for assessment of image quality. Transl Vis Sci Technol. 2019 May 8; 8(3):17."},{"issue":"7","key":"B19","series-title":"Biomed Opt Express.","first-page":"3786","article-title":"Retinal magnification factors at the fixation locus derived from schematic eyes with four individualized surfaces","volume":"13","author":"Huang X","year":"2022","unstructured":"Huang X, Anderson T, Dubra A. Retinal magnification factors at the fixation locus derived from schematic eyes with four individualized surfaces. Biomed Opt Express. 2022 Jul 1; 13(7):3786\u2013808."},{"issue":"1","key":"B20","series-title":"BMC Med Res Methodol.","first-page":"243","article-title":"Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis","volume":"24","author":"Abbas A","year":"2024","unstructured":"Abbas A, Hefnawy MT, Negida A. Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis. BMC Med Res Methodol. 2024 Oct 18; 24(1):243."},{"issue":"7650","key":"B21","series-title":"BMJ.","first-page":"924","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt GH","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y,  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr 26; 336(7650):924\u20136."},{"key":"B22","series-title":"BMJ.","first-page":"l6890","article-title":"Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline","volume":"368","author":"Campbell M","year":"2020","unstructured":"Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE,  Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020 Jan 16; 368:l6890."},{"issue":"10","key":"B23","series-title":"JAMA Ophthalmol.","first-page":"1195","article-title":"Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest","volume":"137","author":"Zwart SR","year":"2019","unstructured":"Zwart SR, Laurie SS, Chen JJ, Macias BR, Lee SMC,  Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest. JAMA Ophthalmol. 2019 Oct 1; 137(10):1195\u2013200."},{"issue":"2","key":"B24","series-title":"J Appl Physiol (1985).","first-page":"613","article-title":"Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight","volume":"131","author":"Greenwald SH","year":"2021","unstructured":"Greenwald SH, Macias BR, Lee SMC, Marshall-Goebel K, Ebert DJ,  Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight. J Appl Physiol (1985). 2021 Aug 1; 131(2):613\u201320."},{"issue":"2","key":"B25","series-title":"JAMA Ophthalmol.","first-page":"165","article-title":"Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest","volume":"138","author":"Laurie SS","year":"2020","unstructured":"Laurie SS, Lee SMC, Macias BR, Patel N, Stern C,  Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest. JAMA Ophthalmol. 2020 Feb 1; 138(2):165\u201372."},{"issue":"5","key":"B26","series-title":"J Appl Physiol (1985).","first-page":"1220","article-title":"Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest","volume":"129","author":"Lawley JS","year":"2020","unstructured":"Lawley JS, Babu G, Janssen SLJE, Petersen LG, Hearon CM Jr,  Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest. J Appl Physiol (1985). 2020 Nov 1; 129(5):1220\u201331."},{"key":"B27","article-title":"70 days of 6 degrees-head down tilt bed rest and its impact on ocular parameters [presentation]","author":"Cromwell RL","unstructured":"Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder R, Taibbi G, Vizzeri G. 70 days of 6 degrees-head down tilt bed rest and its impact on ocular parameters [presentation]. Houston (TX): Universities Space Research Association; 2014 Jun 15. Report No.: JSC-CN-31352. Presented at: International Society of Gravitational Physiology (ISGP) 2014 Conference; 2014 June 15\u201320; Waterloo, Toronto, Canada. [Accessed 20 March 2026]. Available from https:\/\/ntrs.nasa.gov\/citations\/20140008716."},{"issue":"13","key":"B28","series-title":"Invest Ophthalmol Vis Sci.","first-page":"21","article-title":"Optic nerve head morphological changes over 12 hours in seated and head-down tilt postures","volume":"61","author":"Pardon LP","year":"2020","unstructured":"Pardon LP, Cheng H, Chettry P, Patel NB. Optic nerve head morphological changes over 12 hours in seated and head-down tilt postures. Invest Ophthalmol Vis Sci. 2020 Nov 2; 61(13):21."},{"issue":"4","key":"B29","series-title":"Br J Ophthalmol.","first-page":"493","article-title":"Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography","volume":"99","author":"Rim TH","year":"2015","unstructured":"Rim TH, Lee CS, Kim K, Kim SS. Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography. Br J Ophthalmol. 2015 Apr; 99(4):493\u20139."},{"issue":"4","key":"B30","series-title":"Aviat Space Environ Med.","first-page":"388","article-title":"Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt","volume":"83","author":"Shinojima A","year":"2012","unstructured":"Shinojima A, Iwasaki K-I, Aoki K, Ogawa Y, Yanagida R, Yuzawa M. Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt. Aviat Space Environ Med. 2012 Apr; 83(4):388\u201393."},{"issue":"5","key":"B31","series-title":"Surv Ophthalmol.","first-page":"445","article-title":"Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients","volume":"55","author":"Prata TS","year":"2010","unstructured":"Prata TS, De Moraes CGV, Kanadani FN, Ritch R, Paranhos A. Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients. Surv Ophthalmol. 2010 Jul 16; 55(5):445\u201353."},{"key":"B32","series-title":"Front Physiol.","first-page":"933450","article-title":"Acute effects of postural changes and lower body positive and negative pressure on the eye","volume":"13","author":"Van Akin MP","year":"2022","unstructured":"Van Akin MP, Lantz OM, Fellows AM, Toutain-Kidd C, Zegans M,  Acute effects of postural changes and lower body positive and negative pressure on the eye. Front Physiol. 2022 Aug 31; 13:933450."},{"issue":"2","key":"B33","series-title":"Aviat Space Environ Med.","first-page":"148","article-title":"Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject","volume":"84","author":"Taibbi G","year":"2013","unstructured":"Taibbi G, Kaplowitz K, Cromwell RL, Godley BF, Zanello SB, Vizzeri G. Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject. Aviat Space Environ Med. 2013 Feb; 84(2):148\u201354."},{"issue":"3","key":"B34","series-title":"J Glaucoma.","first-page":"204","article-title":"Changes in intraocular pressure during prolonged (7-day) head-down tilt bedrest","volume":"12","author":"Chiquet C","year":"2003","unstructured":"Chiquet C, Custaud M-A, Le Traon AP, Millet C, Gharib C, Denis P. Changes in intraocular pressure during prolonged (7-day) head-down tilt bedrest. J Glaucoma. 2003 Jun; 12(3):204\u20138."},{"issue":"4","key":"B35","series-title":"J Neuroophthalmol.","first-page":"462","article-title":"Why a one-way ticket to Mars may result in a one-way directional glymphatic flow to the eye","volume":"37","author":"Wostyn P","year":"2017","unstructured":"Wostyn P, Killer HE, De Deyn PP. Why a one-way ticket to Mars may result in a one-way directional glymphatic flow to the eye. J Neuroophthalmol. 2017 Dec; 37(4):462\u20133."},{"issue":"8","key":"B36","series-title":"JAMA Ophthalmol.","first-page":"763","article-title":"Changes in optic nerve head and retinal morphology during spaceflight and acute fluid shift reversal","volume":"140","author":"Pardon LP","year":"2022","unstructured":"Pardon LP, Macias BR, Ferguson CR, Greenwald SH, Ploutz-Snyder R,  Changes in optic nerve head and retinal morphology during spaceflight and acute fluid shift reversal. JAMA Ophthalmol. 2022 Aug 1; 140(8):763\u201370."},{"issue":"1","key":"B37","series-title":"Aviat Space Environ Med.","first-page":"64","article-title":"Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space","volume":"83","author":"Wiener TC.","year":"2012","unstructured":"Wiener TC. Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space. Aviat Space Environ Med. 2012 Jan; 83(1):64\u20136."},{"issue":"2","key":"B38","series-title":"J Appl Physiol (1985).","first-page":"352","article-title":"The impact of ocular hemodynamics and intracranial pressure on intraocular pressure during acute gravitational changes","volume":"123","author":"Nelson ES","year":"2017","unstructured":"Nelson ES, Mulugeta L, Feola A, Raykin J, Myers JG,  The impact of ocular hemodynamics and intracranial pressure on intraocular pressure during acute gravitational changes. J Appl Physiol (1985). 2017 Aug 1; 123(2):352\u201363."},{"issue":"6","key":"B39","series-title":"J Appl Physiol (1985).","first-page":"1349","article-title":"MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6\u00b0 head-down tilt bed rest with and without daily centrifugation","volume":"133","author":"Sater SH","year":"2022","unstructured":"Sater SH, Conley Natividad G, Seiner AJ, Fu AQ, Shrestha D,  MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6\u00b0 head-down tilt bed rest with and without daily centrifugation. J Appl Physiol (1985). 2022 Dec 1; 133(6):1349\u201355."},{"issue":"4","key":"B40","series-title":"Am J Ophthalmol.","first-page":"523","article-title":"Intraocular and episcleral venous pressure increase during inverted posture","volume":"103","author":"Friberg TR","year":"1987","unstructured":"Friberg TR, Sanborn G, Weinreb RN. Intraocular and episcleral venous pressure increase during inverted posture. Am J Ophthalmol. 1987 Apr 15; 103(4):523\u20136."},{"issue":"11","key":"B41","series-title":"Br J Ophthalmol.","first-page":"1547","article-title":"The effect of head tilt on the measurements of retinal nerve fibre layer and macular thickness by spectral-domain optical coherence tomography","volume":"95","author":"Hwang YH","year":"2011","unstructured":"Hwang YH, Lee JY, Kim YY. The effect of head tilt on the measurements of retinal nerve fibre layer and macular thickness by spectral-domain optical coherence tomography. Br J Ophthalmol. 2011 Nov; 95(11):1547\u201351."},{"issue":"1","key":"B42","series-title":"Aerosp Med Hum Perform.","first-page":"10","article-title":"Intracranial and intraocular pressure during various degrees of head-down tilt","volume":"88","author":"Marshall-Goebel K","year":"2017","unstructured":"Marshall-Goebel K, Mulder E, Bershad E, Laing C, Eklund A,  Intracranial and intraocular pressure during various degrees of head-down tilt. Aerosp Med Hum Perform. 2017 Jan 1; 88(1):10\u20136."},{"issue":"1","key":"B43","series-title":"JAMA Ophthalmol.","first-page":"59","article-title":"Effect of nightly lower body negative pressure on choroid engorgement in a model of spaceflight-associated neuro-ocular syndrome: a randomized crossover trial","volume":"140","author":"Hearon CM","year":"2022","unstructured":"Hearon CM Jr, Dias KA, Babu G, Marshall JET, Leidner J,  Effect of nightly lower body negative pressure on choroid engorgement in a model of spaceflight-associated neuro-ocular syndrome: a randomized crossover trial. JAMA Ophthalmol. 2022 Jan 1; 140(1):59\u201365."},{"issue":"3","key":"B44","series-title":"Invest Ophthalmol Vis Sci.","first-page":"32","article-title":"Ocular deformations in spaceflight-associated neuro-ocular syndrome and idiopathic intracranial hypertension","volume":"64","author":"Sibony PA","year":"2023","unstructured":"Sibony PA, Laurie SS, Ferguson CR, Pardon LP, Young M,  Ocular deformations in spaceflight-associated neuro-ocular syndrome and idiopathic intracranial hypertension. Invest Ophthalmol Vis Sci. 2023 Mar 1; 64(3):32."},{"issue":"5","key":"B45","series-title":"J Occup Environ Med.","first-page":"477","article-title":"Relationship between carbon dioxide levels and reported headaches on the International Space Station","volume":"56","author":"Law J","year":"2014","unstructured":"Law J, Van Baalen M, Foy M, Mason SS, Mendez C,  Relationship between carbon dioxide levels and reported headaches on the International Space Station. J Occup Environ Med. 2014 May; 56(5):477\u201383. Erratum in: J Occup Environ Med. 2014 Sep; 56(9):e82."},{"issue":"4","key":"B46","series-title":"J Urol.","first-page":"1213","article-title":"The effect of the modified Z Trendelenburg position on intraocular pressure during robotic assisted laparoscopic radical prostatectomy: a randomized, controlled study","volume":"193","author":"Raz O","year":"2015","unstructured":"Raz O, Boesel TW, Arianayagam M, Lau H, Vass J,  The effect of the modified Z Trendelenburg position on intraocular pressure during robotic assisted laparoscopic radical prostatectomy: a randomized, controlled study. J Urol. 2015 Apr; 193(4):1213\u20139."},{"issue":"10","key":"B1","series-title":"Ophthalmology.","first-page":"2058","article-title":"Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight","volume":"118","author":"Mader TH","year":"2011","unstructured":"Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG,  Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011 Oct; 118(10):2058\u201369."},{"key":"B2","series-title":"Front Neurol.","first-page":"648958","article-title":"Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome","volume":"12","author":"Ong J","year":"2021","unstructured":"Ong J, Lee AG, Moss HE. Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome. Front Neurol. 2021 Mar 26; 12:648958."},{"key":"B3","series-title":"NPJ Microgravity.","first-page":"7","article-title":"Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update","volume":"6","author":"Lee AG","year":"2020","unstructured":"Lee AG, Mader TH, Gibson CR, Tarver W, Rabiei P,  Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update. NPJ Microgravity. 2020 Feb 7; 6:7."},{"issue":"7","key":"B4","series-title":"Br J Ophthalmol.","first-page":"895","article-title":"Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures","volume":"107","author":"Ong J","year":"2023","unstructured":"Ong J, Tarver W, Brunstetter T, Mader TH, Gibson CR,  Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures. Br J Ophthalmol. 2023 Jul; 107(7):895\u2013900."},{"issue":"2","key":"B5","series-title":"J Neuroophthalmol.","first-page":"133","article-title":"Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis","volume":"37","author":"Mader TH","year":"2017","unstructured":"Mader TH, Gibson CR, Otto CA, Sargsyan AE, Miller NR,  Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis. J Neuroophthalmol. 2017 Jun; 37(2):133\u20139."},{"issue":"1","key":"B6","series-title":"Neuroophthalmology.","first-page":"29","article-title":"Persistent globe flattening in astronauts following long-duration spaceflight","volume":"45","author":"Mader TH","year":"2020","unstructured":"Mader TH, Gibson CR, Barratt MR, Miller NR, Subramanian PS,  Persistent globe flattening in astronauts following long-duration spaceflight. Neuroophthalmology. 2020 Sep 3; 45(1):29\u201335."},{"issue":"4","key":"B7","series-title":"Life (Basel).","first-page":"621","article-title":"Microgravity-induced fluid shift and ophthalmic changes","volume":"4","author":"Nelson ES","year":"2014","unstructured":"Nelson ES, Mulugeta L, Myers JG. Microgravity-induced fluid shift and ophthalmic changes. Life (Basel). 2014 Nov 7; 4(4):621\u201365."},{"issue":"1","key":"B8","series-title":"J Magn Reson Imaging.","first-page":"206","article-title":"Role of the spinal canal compliance in regulating posture-related cerebrospinal fluid hydrodynamics in humans","volume":"54","author":"Alperin N","year":"2021","unstructured":"Alperin N, Burman R, Lee SH. Role of the spinal canal compliance in regulating posture-related cerebrospinal fluid hydrodynamics in humans. J Magn Reson Imaging. 2021 Jul; 54(1):206\u201314."},{"issue":"5","key":"B9","series-title":"JAMA Ophthalmol.","first-page":"553","article-title":"Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery","volume":"138","author":"Macias BR","year":"2020","unstructured":"Macias BR, Patel NB, Gibson CR, Samuels BC, Laurie SS,  Association of long-duration spaceflight with anterior and posterior ocular structure changes in astronauts and their recovery. JAMA Ophthalmol. 2020 May 1; 138(5):553\u20139."},{"issue":"10","key":"B10","series-title":"Aviat Space Environ Med.","first-page":"983","article-title":"Ocular outcomes evaluation in a 14-day head-down bed rest study","volume":"85","author":"Taibbi G","year":"2014","unstructured":"Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ,  Ocular outcomes evaluation in a 14-day head-down bed rest study. Aviat Space Environ Med. 2014 Oct; 85(10):983\u201392."},{"issue":"15","key":"B11","series-title":"Physiol Rep.","first-page":"e14977","article-title":"Optic disc edema and chorioretinal folds develop during strict 6\u00b0 head-down tilt bed rest with or without artificial gravity","volume":"9","author":"Laurie SS","year":"2021","unstructured":"Laurie SS, Greenwald SH, Marshall-Goebel K, Pardon LP, Gupta A,  Optic disc edema and chorioretinal folds develop during strict 6\u00b0 head-down tilt bed rest with or without artificial gravity. Physiol Rep. 2021 Aug; 9(15):e14977."},{"issue":"2","key":"B12","series-title":"JAMA Ophthalmol.","first-page":"193","article-title":"Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station astronauts","volume":"136","author":"Patel N","year":"2018","unstructured":"Patel N, Pass A, Mason S, Gibson CR, Otto C. Optical coherence tomography analysis of the optic nerve head and surrounding structures in long-duration International Space Station astronauts. JAMA Ophthalmol. 2018 Feb 1; 136(2):193\u2013200."},{"issue":"1","key":"B13","series-title":"Fluids Barriers CNS.","first-page":"85","article-title":"Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension","volume":"19","author":"Mitchell JL","year":"2022","unstructured":"Mitchell JL, Buckham R, Lyons H, Walker JK, Yiangou A,  Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension. Fluids Barriers CNS. 2022 Nov 1; 19(1):85."},{"issue":"3","key":"B14","series-title":"J Glaucoma.","first-page":"255","article-title":"Head-down posture induces PERG alterations in early glaucoma","volume":"22","author":"Ventura LM","year":"2013","unstructured":"Ventura LM, Golubev I, Lee W, Nose I, Parel J-M,  Head-down posture induces PERG alterations in early glaucoma. J Glaucoma. 2013 Mar; 22(3):255\u201364."},{"issue":"8","key":"B15","series-title":"J Ocul Pharmacol Ther.","first-page":"598","article-title":"The effect of posture on intraocular pressure and systemic hemodynamic parameters in treated and untreated patients with primary open-angle glaucoma","volume":"33","author":"Katsanos A","year":"2017","unstructured":"Katsanos A, Dastiridou AI, Quaranta L, Rulli E, Riva I,  The effect of posture on intraocular pressure and systemic hemodynamic parameters in treated and untreated patients with primary open-angle glaucoma. J Ocul Pharmacol Ther. 2017 Oct; 33(8):598\u2013603."},{"issue":"7","key":"B16","series-title":"Aerosp Med Hum Perform.","first-page":"633","article-title":"Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest","volume":"88","author":"Taibbi G","year":"2017","unstructured":"Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ,  Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest. Aerosp Med Hum Perform. 2017 Jul 1; 88(7):633\u201340."},{"issue":"3","key":"B17","series-title":"Rev Lat Am Enfermagem.","first-page":"508","article-title":"The PICO strategy for the research question construction and evidence search","volume":"15","author":"da Costa Santos CM","year":"2007","unstructured":"da Costa Santos CM, de Mattos Pimenta CA, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007 Jun; 15(3):508\u201311."},{"issue":"3","key":"B18","series-title":"Transl Vis Sci Technol.","first-page":"17","article-title":"Repeatability of adaptive optics automated cone measurements in subjects with retinitis pigmentosa and novel metrics for assessment of image quality","volume":"8","author":"Gale MJ","year":"2019","unstructured":"Gale MJ, Harman GA, Chen J, Pennesi ME. Repeatability of adaptive optics automated cone measurements in subjects with retinitis pigmentosa and novel metrics for assessment of image quality. Transl Vis Sci Technol. 2019 May 8; 8(3):17."},{"issue":"7","key":"B19","series-title":"Biomed Opt Express.","first-page":"3786","article-title":"Retinal magnification factors at the fixation locus derived from schematic eyes with four individualized surfaces","volume":"13","author":"Huang X","year":"2022","unstructured":"Huang X, Anderson T, Dubra A. Retinal magnification factors at the fixation locus derived from schematic eyes with four individualized surfaces. Biomed Opt Express. 2022 Jul 1; 13(7):3786\u2013808."},{"issue":"1","key":"B20","series-title":"BMC Med Res Methodol.","first-page":"243","article-title":"Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis","volume":"24","author":"Abbas A","year":"2024","unstructured":"Abbas A, Hefnawy MT, Negida A. Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis. BMC Med Res Methodol. 2024 Oct 18; 24(1):243."},{"issue":"7650","key":"B21","series-title":"BMJ.","first-page":"924","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt GH","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y,  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr 26; 336(7650):924\u20136."},{"key":"B22","series-title":"BMJ.","first-page":"l6890","article-title":"Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline","volume":"368","author":"Campbell M","year":"2020","unstructured":"Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE,  Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020 Jan 16; 368:l6890."},{"issue":"10","key":"B23","series-title":"JAMA Ophthalmol.","first-page":"1195","article-title":"Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest","volume":"137","author":"Zwart SR","year":"2019","unstructured":"Zwart SR, Laurie SS, Chen JJ, Macias BR, Lee SMC,  Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest. JAMA Ophthalmol. 2019 Oct 1; 137(10):1195\u2013200."},{"issue":"2","key":"B24","series-title":"J Appl Physiol (1985).","first-page":"613","article-title":"Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight","volume":"131","author":"Greenwald SH","year":"2021","unstructured":"Greenwald SH, Macias BR, Lee SMC, Marshall-Goebel K, Ebert DJ,  Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight. J Appl Physiol (1985). 2021 Aug 1; 131(2):613\u201320."},{"issue":"2","key":"B25","series-title":"JAMA Ophthalmol.","first-page":"165","article-title":"Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest","volume":"138","author":"Laurie SS","year":"2020","unstructured":"Laurie SS, Lee SMC, Macias BR, Patel N, Stern C,  Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest. JAMA Ophthalmol. 2020 Feb 1; 138(2):165\u201372."},{"issue":"5","key":"B26","series-title":"J Appl Physiol (1985).","first-page":"1220","article-title":"Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest","volume":"129","author":"Lawley JS","year":"2020","unstructured":"Lawley JS, Babu G, Janssen SLJE, Petersen LG, Hearon CM Jr,  Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest. J Appl Physiol (1985). 2020 Nov 1; 129(5):1220\u201331."},{"key":"B27","article-title":"70 days of 6 degrees-head down tilt bed rest and its impact on ocular parameters [presentation]","author":"Cromwell RL","unstructured":"Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder R, Taibbi G, Vizzeri G. 70 days of 6 degrees-head down tilt bed rest and its impact on ocular parameters [presentation]. Houston (TX): Universities Space Research Association; 2014 Jun 15. Report No.: JSC-CN-31352. Presented at: International Society of Gravitational Physiology (ISGP) 2014 Conference; 2014 June 15\u201320; Waterloo, Toronto, Canada. [Accessed 20 March 2026]. Available from https:\/\/ntrs.nasa.gov\/citations\/20140008716."},{"issue":"13","key":"B28","series-title":"Invest Ophthalmol Vis Sci.","first-page":"21","article-title":"Optic nerve head morphological changes over 12 hours in seated and head-down tilt postures","volume":"61","author":"Pardon LP","year":"2020","unstructured":"Pardon LP, Cheng H, Chettry P, Patel NB. Optic nerve head morphological changes over 12 hours in seated and head-down tilt postures. Invest Ophthalmol Vis Sci. 2020 Nov 2; 61(13):21."},{"issue":"4","key":"B29","series-title":"Br J Ophthalmol.","first-page":"493","article-title":"Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography","volume":"99","author":"Rim TH","year":"2015","unstructured":"Rim TH, Lee CS, Kim K, Kim SS. Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography. Br J Ophthalmol. 2015 Apr; 99(4):493\u20139."},{"issue":"4","key":"B30","series-title":"Aviat Space Environ Med.","first-page":"388","article-title":"Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt","volume":"83","author":"Shinojima A","year":"2012","unstructured":"Shinojima A, Iwasaki K-I, Aoki K, Ogawa Y, Yanagida R, Yuzawa M. Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt. Aviat Space Environ Med. 2012 Apr; 83(4):388\u201393."},{"issue":"5","key":"B31","series-title":"Surv Ophthalmol.","first-page":"445","article-title":"Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients","volume":"55","author":"Prata TS","year":"2010","unstructured":"Prata TS, De Moraes CGV, Kanadani FN, Ritch R, Paranhos A. Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients. Surv Ophthalmol. 2010 Jul 16; 55(5):445\u201353."},{"key":"B32","series-title":"Front Physiol.","first-page":"933450","article-title":"Acute effects of postural changes and lower body positive and negative pressure on the eye","volume":"13","author":"Van Akin MP","year":"2022","unstructured":"Van Akin MP, Lantz OM, Fellows AM, Toutain-Kidd C, Zegans M,  Acute effects of postural changes and lower body positive and negative pressure on the eye. Front Physiol. 2022 Aug 31; 13:933450."},{"issue":"2","key":"B33","series-title":"Aviat Space Environ Med.","first-page":"148","article-title":"Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject","volume":"84","author":"Taibbi G","year":"2013","unstructured":"Taibbi G, Kaplowitz K, Cromwell RL, Godley BF, Zanello SB, Vizzeri G. Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject. Aviat Space Environ Med. 2013 Feb; 84(2):148\u201354."},{"issue":"3","key":"B34","series-title":"J Glaucoma.","first-page":"204","article-title":"Changes in intraocular pressure during prolonged (7-day) head-down tilt bedrest","volume":"12","author":"Chiquet C","year":"2003","unstructured":"Chiquet C, Custaud M-A, Le Traon AP, Millet C, Gharib C, Denis P. Changes in intraocular pressure during prolonged (7-day) head-down tilt bedrest. J Glaucoma. 2003 Jun; 12(3):204\u20138."},{"issue":"4","key":"B35","series-title":"J Neuroophthalmol.","first-page":"462","article-title":"Why a one-way ticket to Mars may result in a one-way directional glymphatic flow to the eye","volume":"37","author":"Wostyn P","year":"2017","unstructured":"Wostyn P, Killer HE, De Deyn PP. Why a one-way ticket to Mars may result in a one-way directional glymphatic flow to the eye. J Neuroophthalmol. 2017 Dec; 37(4):462\u20133."},{"issue":"8","key":"B36","series-title":"JAMA Ophthalmol.","first-page":"763","article-title":"Changes in optic nerve head and retinal morphology during spaceflight and acute fluid shift reversal","volume":"140","author":"Pardon LP","year":"2022","unstructured":"Pardon LP, Macias BR, Ferguson CR, Greenwald SH, Ploutz-Snyder R,  Changes in optic nerve head and retinal morphology during spaceflight and acute fluid shift reversal. JAMA Ophthalmol. 2022 Aug 1; 140(8):763\u201370."},{"issue":"1","key":"B37","series-title":"Aviat Space Environ Med.","first-page":"64","article-title":"Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space","volume":"83","author":"Wiener TC.","year":"2012","unstructured":"Wiener TC. Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space. Aviat Space Environ Med. 2012 Jan; 83(1):64\u20136."},{"issue":"2","key":"B38","series-title":"J Appl Physiol (1985).","first-page":"352","article-title":"The impact of ocular hemodynamics and intracranial pressure on intraocular pressure during acute gravitational changes","volume":"123","author":"Nelson ES","year":"2017","unstructured":"Nelson ES, Mulugeta L, Feola A, Raykin J, Myers JG,  The impact of ocular hemodynamics and intracranial pressure on intraocular pressure during acute gravitational changes. J Appl Physiol (1985). 2017 Aug 1; 123(2):352\u201363."},{"issue":"6","key":"B39","series-title":"J Appl Physiol (1985).","first-page":"1349","article-title":"MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6\u00b0 head-down tilt bed rest with and without daily centrifugation","volume":"133","author":"Sater SH","year":"2022","unstructured":"Sater SH, Conley Natividad G, Seiner AJ, Fu AQ, Shrestha D,  MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6\u00b0 head-down tilt bed rest with and without daily centrifugation. J Appl Physiol (1985). 2022 Dec 1; 133(6):1349\u201355."},{"issue":"4","key":"B40","series-title":"Am J Ophthalmol.","first-page":"523","article-title":"Intraocular and episcleral venous pressure increase during inverted posture","volume":"103","author":"Friberg TR","year":"1987","unstructured":"Friberg TR, Sanborn G, Weinreb RN. Intraocular and episcleral venous pressure increase during inverted posture. Am J Ophthalmol. 1987 Apr 15; 103(4):523\u20136."},{"issue":"11","key":"B41","series-title":"Br J Ophthalmol.","first-page":"1547","article-title":"The effect of head tilt on the measurements of retinal nerve fibre layer and macular thickness by spectral-domain optical coherence tomography","volume":"95","author":"Hwang YH","year":"2011","unstructured":"Hwang YH, Lee JY, Kim YY. The effect of head tilt on the measurements of retinal nerve fibre layer and macular thickness by spectral-domain optical coherence tomography. Br J Ophthalmol. 2011 Nov; 95(11):1547\u201351."},{"issue":"1","key":"B42","series-title":"Aerosp Med Hum Perform.","first-page":"10","article-title":"Intracranial and intraocular pressure during various degrees of head-down tilt","volume":"88","author":"Marshall-Goebel K","year":"2017","unstructured":"Marshall-Goebel K, Mulder E, Bershad E, Laing C, Eklund A,  Intracranial and intraocular pressure during various degrees of head-down tilt. Aerosp Med Hum Perform. 2017 Jan 1; 88(1):10\u20136."},{"issue":"1","key":"B43","series-title":"JAMA Ophthalmol.","first-page":"59","article-title":"Effect of nightly lower body negative pressure on choroid engorgement in a model of spaceflight-associated neuro-ocular syndrome: a randomized crossover trial","volume":"140","author":"Hearon CM","year":"2022","unstructured":"Hearon CM Jr, Dias KA, Babu G, Marshall JET, Leidner J,  Effect of nightly lower body negative pressure on choroid engorgement in a model of spaceflight-associated neuro-ocular syndrome: a randomized crossover trial. JAMA Ophthalmol. 2022 Jan 1; 140(1):59\u201365."},{"issue":"3","key":"B44","series-title":"Invest Ophthalmol Vis Sci.","first-page":"32","article-title":"Ocular deformations in spaceflight-associated neuro-ocular syndrome and idiopathic intracranial hypertension","volume":"64","author":"Sibony PA","year":"2023","unstructured":"Sibony PA, Laurie SS, Ferguson CR, Pardon LP, Young M,  Ocular deformations in spaceflight-associated neuro-ocular syndrome and idiopathic intracranial hypertension. Invest Ophthalmol Vis Sci. 2023 Mar 1; 64(3):32."},{"issue":"5","key":"B45","series-title":"J Occup Environ Med.","first-page":"477","article-title":"Relationship between carbon dioxide levels and reported headaches on the International Space Station","volume":"56","author":"Law J","year":"2014","unstructured":"Law J, Van Baalen M, Foy M, Mason SS, Mendez C,  Relationship between carbon dioxide levels and reported headaches on the International Space Station. J Occup Environ Med. 2014 May; 56(5):477\u201383. Erratum in: J Occup Environ Med. 2014 Sep; 56(9):e82."},{"issue":"4","key":"B46","series-title":"J Urol.","first-page":"1213","article-title":"The effect of the modified Z Trendelenburg position on intraocular pressure during robotic assisted laparoscopic radical prostatectomy: a randomized, controlled study","volume":"193","author":"Raz O","year":"2015","unstructured":"Raz O, Boesel TW, Arianayagam M, Lau H, Vass J,  The effect of the modified Z Trendelenburg position on intraocular pressure during robotic assisted laparoscopic radical prostatectomy: a randomized, controlled study. J Urol. 2015 Apr; 193(4):1213\u20139."}],"container-title":["Aerospace Medicine and Human Performance"],"original-title":[],"link":[{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/97\/5\/article-p362.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/97\/5\/article-p362.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asma.kglmeridian.com\/downloadpdf\/journals\/amhp\/97\/5\/article-p362.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:04Z","timestamp":1777341544000},"score":1,"resource":{"primary":{"URL":"https:\/\/asma.kglmeridian.com\/view\/journals\/amhp\/97\/5\/article-p362.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":92,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3357\/amhp.6777.2026","relation":{},"ISSN":["2375-6314","2375-6322"],"issn-type":[{"value":"2375-6314","type":"print"},{"value":"2375-6322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}