{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:56:45Z","timestamp":1780541805677,"version":"3.54.1"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>BACKGROUND\/AIMS: Doxorubicin (DOXO) is a potent chemotherapeutic drug that is used in the treatment of a large number of cancers. Despite its important chemotherapeutic characteristics, its usage is limited because of the serious side effects; the most noticeable is cardiotoxicity which can manifest acutely or years after completion of treatment leading to left ventricular dysfunction, dilated cardiomyopathy and heart failure. Nootkatone (NK) is a recognized bioactive compound isolated from the heartwood of Cupressus nootkatensis and has been reported to have antiseptic, antioxidant, and anti-allergic activities. METHODS: Male C57B6\/J mice were used for mice model of DOXO-cardiac toxicity. Mice were given either DOXO or NK or DOXO+NK or vehicle (normal saline) after which the mice again had free access to food and water. Heart and plasma samples were collected 5 days after DOXO administration and were used for immunohistochemistry, electron microscopy and enzyme linked immunosorbent assay (ELISA). RESULTS: There were significant reduction in inflammatory markers in hearts of DOXO-NK- treated mice when compared with DOXO-treated mice. Moreover, there were significant increase in antioxidant proteins and reduction of oxidative stress in hearts of DOXO-NK-treated mice when compared with DOXO-treated mice. There was a significant reduction in myocardial damage as shown by significant reduction of troponin I in DOXO-NK- treated mice when compared with DOXO-treated mice. CONCLUSION: Nootkatone improves DOXO-induced myocardial injury through modulation of NF-\u03baB signals and reduction of oxidative stress.<\/jats:p>","DOI":"10.33594\/000000559","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T18:41:01Z","timestamp":1661366461000},"page":"401-417","source":"Crossref","is-referenced-by-count":16,"title":["Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-\u03baB Signals and Oxidative Stress"],"prefix":"10.33594","volume":"56","member":"19235","published-online":{"date-parts":[[2022,8,25]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T18:41:04Z","timestamp":1661366464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellphysiolbiochem.com\/Articles\/000559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,25]]}},"URL":"https:\/\/doi.org\/10.33594\/000000559","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,25]]}}}