{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:54:26Z","timestamp":1789844066456,"version":"4.0.1"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>Background\/Aims: Ischemic reperfusion (I-R) injury is greatly influenced by the testicular torsion\/detorsion process (TDP). In this instance, the anti-inflammatory properties of platelet-rich plasma (PRP) combined with tadalafil (Td) significantly promote tissue healing in the I-R injury model. Methods: Five groups of rats were created: the control group, the I-R group not receiving any therapy, the I-R group receiving a single dosage of Td (0.25 mg\/kg, I.P.), the I-R group receiving a single dose of PRP (80 l, intratesticular), and the I-R group receiving both Td and PRP. Sperm morphology, motility, and histology were assessed. The levels of TNF-, BAX, antioxidant status, and testosterone were measured. Additionally, E-selectin expression was done. Results: PRP reduced oxidative stress, inflammation, and apoptosis while also boosting testosterone levels, which alleviated I-R injury. Otherwise, PRP reduces E-selectin expression, which modifies the pathways that control endothelial function. Td also partially demonstrated its testicular-protective activity at the same time. Conclusion: PRP's proven anti-inflammatory, antioxidant, and antiapoptotic potentials make it a natural treatment for testicular harm caused by tadalafil. For the first time, it was demonstrated that PRP therapy restored the functionality of the vascular endothelium, specifically the control of E-selectin expression. Combining Td and PRP therapy may be a promising strategy for improving response to PDE5 inhibitors.<\/jats:p>","DOI":"10.33594\/000000680","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T19:41:50Z","timestamp":1705520510000},"page":"14-32","source":"Crossref","is-referenced-by-count":8,"title":["Insights on Protective Effect of Platelet Rich Plasma and Tadalafil on Testicular Ischemia\/Reperfusion Injury in Rats Exposed to Testicular Torsion\/Detorsion"],"prefix":"10.33594","volume":"58","member":"19235","published-online":{"date-parts":[[2024,1,16]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T19:41:51Z","timestamp":1705520511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellphysiolbiochem.com\/Articles\/000680\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.33594\/000000680","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}