{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:19:06Z","timestamp":1782746346693,"version":"3.54.5"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>Background\/Aims: Acinetobacter baumannii is a ubiquitous opportunistic microorganism associated with high morbidity and mortality Particularly among burn patients and immunocompromised individuals. This study aimed to assess the time-dependent antimicrobial effectiveness of indolicidin in combination with tigecycline against multidrug-resistant (MDR) A. baumannii isolates from patients with wound infections. Methods: The antimicrobial synergy between indolicidin and tigecycline was evaluated using the checkerboard broth microdilution method And anti-biofilm activity was assessed using the crystal violet assay. Ten isolates resistant to multiple antibiotics were identified and confirmed using the API 20-NE system. Results: Fractional inhibitory concentration (FIC) values ranged from 0.97 to 250 \u00b5g\/ml. The results demonstrated that the inhibitory activity of indolicidin and tigecycline was significantly enhanced when combined With FIC values between 0.046 and 0.312 \u00b5g\/ml. The MIC of indolicidin for isolate A4 decreased from 62.5 to 0.97 \u00b5g\/ml \u2022 While the MIC of tigecycline decreased from 500 to 15.6 \u00b5g\/ml \u2022 Indicating a strong synergistic effect. Additionally The combination therapy led to a 78% reduction in biofilm formation. Conclusion: This study suggests a novel combination therapy for treating wound infections caused by MDR A. baumannii \u2022 Demonstrating significant efficacy in both bacterial inhibition and biofilm reduction.<\/jats:p>","DOI":"10.33594\/000000759","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:05:52Z","timestamp":1740405952000},"page":"92-99","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Activity of Indolicidin and Tigecycline Against Multidrug-Resistant Acinetobacter Baumannii Clinical Isolates"],"prefix":"10.33594","volume":"59","member":"19235","published-online":{"date-parts":[[2025,1,24]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:05:53Z","timestamp":1740405953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellphysiolbiochem.com\/Articles\/000759\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,24]]}},"URL":"https:\/\/doi.org\/10.33594\/000000759","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}