{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:13:51Z","timestamp":1791508431575,"version":"4.3.4"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["c"],"abstract":"<jats:p>Background\/Aims: Obesity Resistance (OR) is characterized by limited weight gain and reduced fat accumulation despite an obesogenic diet. However, the metabolic risk, particularly regarding Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), remains unclear. The current study aims to investigate the presence of MASLD, as well as metabolic parameters and morphological aspects of adipose tissues in obesity-resistant (OR) R rats fed a high-fat diet (HFD). Methods: Male Wistar rats (n=71) were initially randomized into two groups: a) standard diet (SD, n=35) and b) high-fat diet (HFD, n=36). The protocol was performed for 14 weeks, including 4 weeks of induction and 10 weeks of exposure to obesity. Subsequently, after applying the tertile classification criterion, the animals were redistributed into three groups: a) control (C, n=12), fed a standard diet; b) obesity-prone (OP, n=12); and c) OR (n=12). Body weight evolution, adiposity, nutritional behavior, metabolic markers, and liver morphology were assessed, along with the staging of MASLD. Results: OR rats exhibited lower body weight, total fat pads, and leptin compared to OP but higher values than C. MASLD was observed in 50% of OR animals, while 37.5% progressed to metabolic dysfunction-associated steatohepatitis (MASH). OP rats had a higher incidence of MASH (87.5%). Conclusion: Chronic HFD exposure in OR rats lead to metabolic changes and MASLD development, including MASH, demonstrating that OR does not protect against HFD-induced hepatic alterations.<\/jats:p>","DOI":"10.33594\/000000791","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T03:07:31Z","timestamp":1751944051000},"page":"434-452","source":"Crossref","is-referenced-by-count":5,"title":["High-Fat Diet Induces MASLD and Adipose Tissue Changes in Obesity-Resistant Rats"],"prefix":"10.33594","volume":"59","author":[{"name":"Postgraduate Program in Nutrition and Health, Health Sciences Center, Department of Integrated Health Education, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Rangel Madureira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Physiological Science, Health Sciences Center, Department of Physiological Sciences, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Valois","family":"Pereira Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Nutrition and Health, Health Sciences Center, Department of Integrated Health Education, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete","family":"Corr\u00eaa Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Physiological Science, Health Sciences Center, Department of Physiological Sciences, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiany","family":"de Oliveira Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Physiological Science, Health Sciences Center, Department of Physiological Sciences, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno","family":"Souza Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Health Sciences Center, Morphology Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidianne","family":"Narducci Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Veterinary Medicine, University of Vila Velha, Vila Velha, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno Valentim","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Health Sciences Center, Department of Morphology, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Soares Leopoldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Nutrition and Health, Health Sciences Center, Department of Integrated Health Education, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Physiological Science, Health Sciences Center, Department of Physiological Sciences, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Physical Education and Sports Center, Sports Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Lima-Leopoldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Postgraduate Program in Nutrition and Health, Health Sciences Center, Department of Integrated Health Education, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Physical Education and Sports Center, Sports Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, (Esp\u00edrito Santo), Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19235","published-online":{"date-parts":[[2025,6,2]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:05:13Z","timestamp":1757405113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cellphysiolbiochem.com\/Articles\/000791\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.33594\/000000791","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]}}}