{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:45:49Z","timestamp":1790091949005,"version":"4.0.1"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>Neurodegenerative diseases (NDDs) are defined by the gradual degeneration of neuronal cells, wherein the accumulation of misfolded proteins can lead to memory impairments, motor dysfunctions, and other deteriorations. Despite the widespread impact, there are currently no viable pharmaceuticals to treat these disorders. Currently, more than 30 million individuals globally endure severe health issues, with few therapeutic alternatives for their management. The mTOR protein is a crucial regulator of cell death signals, survival, growth, and the fate of neural cells. Targeted modulation of mTOR signaling holds the potential for mitigating neurodegeneration in Alzheimer's, Huntington's, Amyotrophic Lateral Sclerosis (ALS), Parkinson's, and other neurodegenerative conditions. However, the advancement of successful mTOR-targeted therapeutics necessitates careful consideration of multiple factors. These include addressing protein aggregation and comprehending the complex interactions of cell death pathways within the neurological system. Additionally, mTOR modulates diverse signaling pathways, encompassing growth factors and proteins, including PI3K (phosphoinositide 3-kinase), Akt, AMPK, and SIRT1. Understanding these connections is crucial for effective therapeutic development. By comprehending the intricacies of the mTOR pathway, researchers have the opportunity to uncover novel and more precise therapies, offering optimism for the future management of NDDs.<\/jats:p>","DOI":"10.33594\/000000858","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:54:23Z","timestamp":1775555663000},"page":"136-174","source":"Crossref","is-referenced-by-count":4,"title":["mTOR Signalling in Neurodegenerative Disorders: Unveiling Key Factors, Mechanistic Insights, and Possible Therapeutic Interventions"],"prefix":"10.33594","volume":"60","author":[{"given":"Niraj Kumar","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioengineering, School of Biosciences and Technology, Galgotias University, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosleh Mohammad","family":"Abomughaid","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Avinash","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajeed G.","family":"Almutary","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, P.O. Box 59911, Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorabh","family":"Lakhanpal","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan M.","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Applied Sciences, University of Technology, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al-kuraishy","sequence":"additional","affiliation":[{"name":"Department of Clinical pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdoon A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graphic Era Deemed to be University, Dehradun 248002, Uttrakhand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Thakur","sequence":"additional","affiliation":[{"name":"Centre for Research Impact and Outcome, Chitkara University, Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Technology, UPES, Dehradun, Uttarakhand 248007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19235","published-online":{"date-parts":[[2026,4,7]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:54:23Z","timestamp":1775555663000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellphysiolbiochem.com\/Articles\/000858\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.33594\/000000858","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]}}}