{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:12:23Z","timestamp":1775805143474,"version":"3.50.1"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>Background\/Aims: We explored the fundamental feasibility, technical frame conditions and effectiveness of transcranial Tumor Destructive Mechanical Impulse (TMI) treatment of brain tumors. Methods: The optimal treatment parameters (total energy required, energy flux density, shock wave frequency) and applicator positions were explored and defined with respect to the special conditions given by propagation of shock waves through the skull. Results: As first clinical observations, we present the outcome of transcranial TMI treatment in two cases with brain metastases of malignant melanoma. In both cases, regression of metastases as well in the brain as in other sites was observed, in one of the cases with a complete tumor free recovery. Conclusion: In these cases, there were no identifiable signs of impairment of the surrounding brain tissue, and even indications of neuro-regenerative effects as described in the cited experimental literature, so that transcranial TMI treatment of brain tumors may be applied for further systematic investigation without any currently discernible risk for the intact surrounding brain tissue.<\/jats:p>","DOI":"10.33594\/000000859","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:23:42Z","timestamp":1775802222000},"page":"175-188","source":"Crossref","is-referenced-by-count":0,"title":["Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part III: Transcranial Application, Immune Profile, Blood-Brain Barrier, Neuroprotection, Neuromodulation and Neurostimulation"],"prefix":"10.33594","volume":"60","author":[{"given":"Axel Erich","family":"Theuer","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology, Charit\u00e9 University Hospital, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Exner","sequence":"additional","affiliation":[{"name":"Pediatrician\u2019s Office, Marktoberdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John David","family":"Mullins","sequence":"additional","affiliation":[{"name":"Shepherd Center Wound Clinic, Piedmont Atlanta Hospital, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Warlick","sequence":"additional","affiliation":[{"name":"SoftWave Tissue Regeneration Technology, Alpharetta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Strassmann","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, University of Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Eigentler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology, Charit\u00e9 University Hospital, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard Franz","family":"Walter","sequence":"additional","affiliation":[{"name":"International Neuroscience Institute, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19235","published-online":{"date-parts":[[2026,4,10]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:23:43Z","timestamp":1775802223000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellphysiolbiochem.com\/Articles\/000859\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,10]]}},"URL":"https:\/\/doi.org\/10.33594\/000000859","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]}}}