{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:11:27Z","timestamp":1780481487361,"version":"3.54.1"},"reference-count":0,"publisher":"Cell Physiol Biochem Press GmbH and Co KG","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Physiol Biochem"],"abstract":"<jats:p>Background\/Aims: To present a clinical case of metabolic syndrome (MetS) and to provide a concise pathophysiological overview with emphasis on underlying metabolic and inflammatory mechanisms. Methods: This study is a case report combined with a focused literature review. We describe a patient with MetS who was evaluated and treated at the Hospital of Vietnam National University in Hanoi, Vietnam. Results: A 20-year-old male presented with headaches and palpitations. Clinical examination revealed obesity (BMI 37.1) with a waist circumference of 111 cm, dyslipidemia (triglycerides\/HDL-cholesterol\/LDL-cholesterol\/total cholesterol: 3.84\/1.15\/4.39\/7.29 mmol\/L), and hyperglycemia (blood glucose 7.07 mmol\/L, HbA1c 7.2%). The patient also exhibited sinus tachycardia (114 beats\/min) and elevated blood pressure (170\/102 mmHg left arm, 162\/100 mmHg right arm), which was confirmed by 24-hour ambulatory blood pressure monitoring. The triglyceride-to-HDL cholesterol ratio (TG\/HDL) was calculated as approximately 3.34, indicating significant insulin resistance and increased cardiovascular risk. Based on these findings, a diagnosis of metabolic syndrome associated with obesity, type 2 diabetes mellitus, and hypertension was established. The clinical phenotype is consistent with adipose tissue dysfunction, chronic low-grade inflammation, and insulin resistance, which contribute to dyslipidemia and activation of neurohormonal pathways such as the renin\u2013angiotensin\u2013aldosterone system. The patient received prompt medical treatment and achieved clinical stabilization. Conclusion: This case highlights the early manifestation of metabolic syndrome and illustrates its underlying pathophysiological mechanisms. Effective management requires early diagnosis and a combined approach including lifestyle modification, weight reduction, and individualized pharmacological therapy to improve metabolic control and reduce the risk of long-term cardiovascular complications.<\/jats:p>","DOI":"10.33594\/000000871","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:21:58Z","timestamp":1780478518000},"page":"280-290","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Syndrome: a Clinical Case Report and Literature Review"],"prefix":"10.33594","volume":"60","author":[{"given":"Si Dung","family":"Chu","sequence":"first","affiliation":[{"name":"Health Management training Institute, Hanoi University of Public Health (HUPH), Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Tran","family":"Pham","sequence":"additional","affiliation":[{"name":"Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vietnam University of Traditional Medicine (VUTM), Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Quoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Board of directors, Vietnam University of Traditional Medicine (VUTM), Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19235","published-online":{"date-parts":[[2026,6,3]]},"container-title":["Cellular Physiology and Biochemistry"],"original-title":[],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:21:59Z","timestamp":1780478519000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellphysiolbiochem.com\/Articles\/000871\/index.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,3]]}},"URL":"https:\/\/doi.org\/10.33594\/000000871","relation":{},"ISSN":["1015-8987","1421-9778"],"issn-type":[{"value":"1015-8987","type":"print"},{"value":"1421-9778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]}}}