{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:04:58Z","timestamp":1758585898101,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":1493,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.3382\/ps\/pev217","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T20:44:22Z","timestamp":1437425062000},"page":"2066-2074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetic and pharmacodynamic properties of gamithromycin in turkey poults with respect to Ornithobacterium rhinotracheale"],"prefix":"10.1016","volume":"94","author":[{"given":"Anneleen","family":"Watteyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Devreese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegrid","family":"De Baere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Wyns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Plessers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Boyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Haesebrouck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siska","family":"Croubels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3382\/ps\/pev217_bib1","first-page":"1041","article-title":"Antimicrobial therapy of selected diseases in turkeys, laying hens, and minor poultry species in Canada","volume":"54","author":"Agunos","year":"2013","journal-title":"Can. Vet. J."},{"key":"10.3382\/ps\/pev217_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cll.2004.03.009","article-title":"Application of pharmacokinetics and pharmacodynamics to antimicrobial therapy of respiratory tract infections","volume":"24","author":"Andes","year":"2004","journal-title":"Clin. Lab. Med."},{"key":"10.3382\/ps\/pev217_bib3","unstructured":"Anonymous Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes 2010"},{"key":"10.3382\/ps\/pev217_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/vr.c6776","article-title":"Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial","volume":"168","author":"Baggott","year":"2011","journal-title":"Vet. Rec."},{"key":"10.3382\/ps\/pev217_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijantimicag.2010.01.023","article-title":"Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic\/pharmacodynamic indices","volume":"35","author":"Barbour","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.3382\/ps\/pev217_bib6","first-page":"672","article-title":"Pulmonary disposition of gamithromycin in foals and in vitro activity of the drug against Rhodococcus Equi and Streptococcus Equi Subsp Zooepidemicus","volume":"25","author":"Berghaus","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"10.3382\/ps\/pev217_bib7","doi-asserted-by":"crossref","first-page":"R327","DOI":"10.1152\/ajpregu.2001.281.1.R327","article-title":"Pulmonary surfactant in birds: coping with surface tension in a tubular lung","volume":"281","author":"Bernhard","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.3382\/ps\/pev217_bib8","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/ps\/77.12.1905","article-title":"Lung lining fluid antioxidants in male broilers: age-related changes under thermoneutral and cold temperature conditions","volume":"77","author":"Bottje","year":"1999","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pev217_bib9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1289\/ehp.97105188","article-title":"The avian respiratory system: a unique model for studies of respiratory toxicosis and for monitoring air quality","volume":"105","author":"Brown","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.3382\/ps\/pev217_bib10","unstructured":"CLSI Clinical and Laboratory Standard Institute. Performance standards for antimicrobial disk and dilution susceptibility test for bacteria isolated from animals: Approved standard - Fourth Edition and Supplement, VET01A4E and VET01S2E 2013 Wayne, PA, USA CLSI"},{"key":"10.3382\/ps\/pev217_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chroma.2015.04.022","article-title":"Development and validation of a liquid chromatography - tandem mass spectrometry method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid","volume":"1398","author":"De Baere","year":"2015","journal-title":"J. Chromatogr. A."},{"key":"10.3382\/ps\/pev217_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/00071668.2013.800942","article-title":"Adherence of five serovars of Ornithobacterium rhinotracheale to chicken tracheal epithelial cells","volume":"54","author":"De Haro-Cruz","year":"2013","journal-title":"Br. Poult. Sc."},{"key":"10.3382\/ps\/pev217_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2885.1984.tb00878.x","article-title":"Effects of erythromycin-inactivating Lactobacillus crop flora on blood levels of erythromycin given orally to chicks","volume":"7","author":"Devriese","year":"1984","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3382\/ps\/pev217_bib14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/vr.137.17.435","article-title":"In-Vitro Antibiotic-Sensitivity of Ornithobacterium rhinotracheale Strains from Poultry and Wild Birds","volume":"137","author":"Devriese","year":"1995","journal-title":"Vet. Rec."},{"key":"10.3382\/ps\/pev217_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03079450120054596","article-title":"Antibiotic sensitivity and resistance in Ornithobacterium rhinotracheale strains from Belgian broiler chickens","volume":"30","author":"Devriese","year":"2001","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib16","first-page":"51","article-title":"Degradation of macrolide-lincosamide-streptogramin antibiotics by Lactobacillus strains from animals","volume":"132A","author":"Dutta","year":"1981","journal-title":"Ann. Microbiol. (Paris)"},{"key":"10.3382\/ps\/pev217_bib17","unstructured":"EMA European Medicines Agency. Committee for Medicinal Products for Veterinary Use. European public MRL assessment report (EPMAR) - Gamithromycin (porcine) 2015 EMA\/CVMP\/350415\/2014. 23 February 2015"},{"key":"10.3382\/ps\/pev217_bib18","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/ps\/77.11.1704","article-title":"Influence of feed deprivation on ventilation and gas exchange in broilers: relationship to pulmonary hypertension syndrome","volume":"77","author":"Fedde","year":"1998","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pev217_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/03079450903055413","article-title":"Efficacy of four enrofloxacin treatment regimens against experimental infection in turkey poults with avian pneumovirus and Ornithobacterium rhinotracheale","volume":"38","author":"Garmyn","year":"2009","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib20","series-title":"Antimicrobial Therapy in Veterinary Medicine","first-page":"211","article-title":"Macrolides, Azalides and Ketolides","author":"Gigu\u00e8re","year":"2013"},{"key":"10.3382\/ps\/pev217_bib21","first-page":"342","article-title":"Rational dosing of antimicrobial agents for Bovine Respiratory Disease: the use of plasma versus tissue concentrations in predicting efficacy","volume":"9","author":"Gigu\u00e8re","year":"2011","journal-title":"Intern. J. Appl. Res. Vet. Med."},{"key":"10.3382\/ps\/pev217_bib22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2460\/ajvr.72.3.326","article-title":"Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells, and lung tissue in cattle","volume":"72","author":"Gigu\u00e8re","year":"2011","journal-title":"Am. J. Vet. Res."},{"key":"10.3382\/ps\/pev217_bib23","series-title":"Avian Immunology","first-page":"251","article-title":"The Avian Respiratory System","author":"H\u00e4rtle","year":"2014"},{"key":"10.3382\/ps\/pev217_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1586\/17476348.1.1.7","article-title":"MICs, MPCs and PK\/PDs: a match (sometimes) made in hosts","volume":"1","author":"Hesje","year":"2007","journal-title":"Expert Rev. Resp. Med."},{"key":"10.3382\/ps\/pev217_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/03079450500268476","article-title":"Development of a lavage procedure to collect lung secretions from chickens for evaluating respiratory humoral immunity","volume":"34","author":"Holt","year":"2005","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2885.2009.01125.x","article-title":"Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity","volume":"33","author":"Huang","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3382\/ps\/pev217_bib27","series-title":"Guide to Antimicrobial Use in Animals","first-page":"77","article-title":"Strategies to minimise the impact of antimicrobial treatment on the selection of resistant bacteria","author":"Lees","year":"2008"},{"key":"10.3382\/ps\/pev217_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.diagmicrobio.2004.12.005","article-title":"Pharmacodynamics of an 800-mg dose of telithromycin in patients with community-acquired pneumonia caused by extracellular pathogens","volume":"52","author":"Lodise","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.3382\/ps\/pev217_bib29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/03079450500096414","article-title":"Synergy between avian pneumovirus and Ornithobacterium rhinotracheale in turkeys","volume":"34","author":"Marien","year":"2005","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vetmic.2006.11.012","article-title":"Efficacy of enrofloxacin, florfenicol and amoxicillin against Ornithobacterium rhinotracheale and Escherichia coli O2:K1 dual infection in turkeys following APV priming","volume":"121","author":"Marien","year":"2007","journal-title":"Vet. Microbiol."},{"key":"10.3382\/ps\/pev217_bib31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/03079450600711052","article-title":"mparison of the efficacy of four antimicrobial treatment schemes against experimental Ornithobacterium rhinotracheale infection in turkey poults pre-infected with avian pneumovirus","volume":"35","author":"Marien","year":"2006","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib32","series-title":"Antimicrobial Therapy in Veterinary Medicine","first-page":"79","article-title":"The pharmacodynamics of antimicrobial agents","author":"Martinez","year":"2013"},{"key":"10.3382\/ps\/pev217_bib33","series-title":"Avian Physiology","first-page":"233","article-title":"Respiration","author":"Powell","year":"2000"},{"key":"10.3382\/ps\/pev217_bib34","first-page":"250","article-title":"Bronchoalveolar lavage","volume":"135","author":"Reynolds","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.3382\/ps\/pev217_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2885.1997.00095.x","article-title":"Interspecies allometric analysis of the womparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species","volume":"20","author":"Riviere","year":"1997","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3382\/ps\/pev217_bib36","unstructured":"Schwarz A. de Gussem M. Van Mullem K. Popp C. Windhaus H. Wijnen P. Klosterhalfen D. G\u00f6hen S. Marien M. In vitro susceptibility of Ornithobacterium rhinotracheale strains isolated from turkeys in Germany and the Netherlands 2012 Salvador, Brazil Abstract book of World Poultry Congress 2012, 5-9 August"},{"issue":"Suppl 1","key":"10.3382\/ps\/pev217_bib37","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S0924-8579(01)00406-X","article-title":"Macrolides: pharmacolinetics and pharmacodynamics","volume":"18","author":"Van Bambeke","year":"2001","journal-title":"Int. J. Antimicrob. Agents."},{"key":"10.3382\/ps\/pev217_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/03079459994704","article-title":"Ornithobacterium rhinotracheale: a review","volume":"28","author":"Van Empel","year":"1999","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib39","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/vr.149.20.611","article-title":"In vitro antibiotic sensitivity of strains of Ornithobacterium rhinotracheale isolated in The Netherlands between 1996 and 1999","volume":"149","author":"van Veen","year":"2001","journal-title":"Vet. Rec."},{"key":"10.3382\/ps\/pev217_bib40","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/vr.165.22.668","article-title":"Control of Ornithobacterium rhinotracheale in poultry","volume":"28","author":"Warner","year":"2009","journal-title":"Vet. Rec."},{"key":"10.3382\/ps\/pev217_bib41","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3382\/ps.2012-02932","article-title":"Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens","volume":"92","author":"Watteyn","year":"2013","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pev217_bib42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1080\/03079457.2013.823144","article-title":"Clinical efficacy of florfenicol administered in the drinking water against Ornithobacterium rhinotracheale in turkeys housed in different environmental conditions: a pharmacokinetic\/pharmacodynamic approach","volume":"42","author":"Watteyn","year":"2013","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pev217_bib43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.rvsc.2013.11.012","article-title":"Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs","volume":"96","author":"Wyns","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"10.3382\/ps\/pev217_bib44","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1128\/JCM.01337-13","article-title":"Isolation and characterization of small-colony variants of Ornithobacterium rhinotracheale","volume":"51","author":"Zahra","year":"2013","journal-title":"J Clin. Microbiol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119322412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119322412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/94\/9\/2066\/4475912\/pev217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T20:49:48Z","timestamp":1758487788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579119322412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0032579119322412"],"URL":"https:\/\/doi.org\/10.3382\/ps\/pev217","relation":{},"ISSN":["0032-5791"],"issn-type":[{"type":"print","value":"0032-5791"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic and pharmacodynamic properties of gamithromycin in turkey poults with respect to Ornithobacterium rhinotracheale","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps\/pev217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}