{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:06:59Z","timestamp":1790320019396,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":672,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3382\/ps\/pex251","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T04:46:34Z","timestamp":1506055594000},"page":"4208-4216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of synbiotic supplementation on layer production and cecal Salmonella load during a Salmonella challenge"],"prefix":"10.1016","volume":"96","author":[{"given":"A","family":"Luoma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Markazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Shanmugasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Murugesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mohnl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3382\/ps\/pex251_bib1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ps\/83.7.1093","article-title":"Microflora ecology of the chicken intestine using 16S ribosomal DNA primers.","volume":"83","author":"Amit-Romach","year":"2004","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib2","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.3382\/ps.0702433","article-title":"Effect of fructooligosaccharide on Salmonella colonization of the chicken intestine.","volume":"70","author":"Bailey","year":"1991","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/03079459108418749","article-title":"Experimental infection of chickens with Salmonella enteritidis.","volume":"20","author":"Barrow","year":"1991","journal-title":"Avian Pathol."},{"key":"10.3382\/ps\/pex251_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-2427(03)00155-7","article-title":"Antibody responses in the serum and gut of chicken lines differing in cecal carriage of Salmonella Enteritidis.","volume":"96","author":"Berthelot-H\u00e9rault","year":"2003","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3382\/ps\/pex251_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2672.1993.tb02993.x","article-title":"Distribution of pathogen inhibition in the Lactobacillus isolates of a commercial probiotic consortium.","volume":"74","author":"Chateau","year":"1993","journal-title":"J. Appl. Bacteriol."},{"key":"10.3382\/ps\/pex251_bib6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/ps\/86.6.1121","article-title":"Microarchitecture and spatial relationship between bacteria and ileal, cecal, and colonic epithelium in chicks fed a direct-fed microbial, PrimaLac, and salinomycin.","volume":"86","author":"Chichlowski","year":"2007","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0165-2427(98)00112-3","article-title":"Role of the humoral immune system in Salmonella enteritidis phage type four infection in chickens.","volume":"63","author":"Desmidt","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3382\/ps\/pex251_bib8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2672.2003.01817.x","article-title":"Investigation of Salmonella contamination and disinfection in farm egg-packing plants.","volume":"94","author":"Davies","year":"2003","journal-title":"J. Applied Micro."},{"key":"10.3382\/ps\/pex251_bib9","first-page":"158","article-title":"Delivery of viable Lactobacillus reuteri to the gastrointestinal tract of poultry.","volume":"70","author":"Dobrogosz","year":"1991","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1128\/CMR.00066-12","article-title":"Salmonella enterica serovar Typhimurium skills to succeed in the host: Virulence and regulation.","volume":"26","author":"Fabrega","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"10.3382\/ps\/pex251_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0145-305X(01)00014-3","article-title":"Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar Enteritidis antigen.","volume":"25","author":"Fukutome","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.3382\/ps\/pex251_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1637\/8090-081807.1","article-title":"Serotype-specific and serotype-independent strategies for preharvest control of food-borne Salmonella in poultry.","volume":"51","author":"Gast","year":"2007","journal-title":"Avian Dis."},{"key":"10.3382\/ps\/pex251_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3382\/ps.2007-00259","article-title":"Association of interleukin-10 cluster genes and Salmonella response in the chicken.","volume":"87","author":"Ghebremicael","year":"2008","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary manipulation of the human colonic microbiota, introducing the concept of prebiotics.","volume":"125","author":"Gibson","year":"1995","journal-title":"J. Nutr."},{"key":"10.3382\/ps\/pex251_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2672.1997.00280.x","article-title":"Antibiotic use in animal agriculture.","volume":"83","author":"Gustafson","year":"1997","journal-title":"J. Applied Micro."},{"key":"10.3382\/ps\/pex251_bib16","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2307\/1591255","article-title":"Biological control of Salmonella typhimurium in young chickens.","volume":"34","author":"Hinton","year":"1990","journal-title":"Avian Dis."},{"key":"10.3382\/ps\/pex251_bib17","first-page":"43","article-title":"The vertical transmission of salmonellas and formic acid treatment of chicken feed.","volume":"100","author":"Humphrey","year":"1988","journal-title":"A possible strategy for control. Epidemiol. Infect."},{"key":"10.3382\/ps\/pex251_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1079\/WPS19980010","article-title":"Natural and synthetic oligosaccharides in broiler chicken diets.","volume":"54","author":"Iji","year":"1998","journal-title":"World's Poult. Sci. J."},{"key":"10.3382\/ps\/pex251_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/00071660410001730851","article-title":"Immunomodulation by probiotic Lactobacilli in layer and meat-type chickens.","volume":"45","author":"Koenen","year":"2004","journal-title":"Br. Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib20","first-page":"683","article-title":"Quantification and distribution of chicken immunoglobulins IgA, IgM and IgG in serum and secretions.","volume":"27","author":"Lebacq-Verheyden","year":"1974","journal-title":"Immunology."},{"key":"10.3382\/ps\/pex251_bib21","first-page":"666","article-title":"Embryo vaccination against Eimeria tenella and E.","volume":"91","author":"Lillehoj","year":"2005","journal-title":"acervulina infections using recombinant proteins and cytokine adjuvants. J. Parasitol."},{"key":"10.3382\/ps\/pex251_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1751-0813.1977.tb14891.x","article-title":"Prevention of Salmonella typhimurium infection inpoultry by pretreatment of chickens and poults with intestinal extracts.","volume":"53","author":"Lloyd","year":"1977","journal-title":"Aust. Vet. J."},{"key":"10.3382\/ps\/pex251_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/tvjl.1999.0423","article-title":"Prospects for \u2018competitive exclusion' treatment to control salmonellas and other foodborne pathogens in poultry.","volume":"159","author":"Mead","year":"2000","journal-title":"Vet. J."},{"key":"10.3382\/ps\/pex251_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1079\/AHR2005103","article-title":"Probiotic alternatives to reduce gastrointestinal infections: The poultry experience.","volume":"6","author":"Nava","year":"2005","journal-title":"Anim. Health Res. Rev."},{"key":"10.3382\/ps\/pex251_bib25","first-page":"1418","article-title":"In vitro fructooligosaccharide utilization and inhibition of Salmonella spp.","volume":"74","author":"Oyarzabal","year":"1995","journal-title":"by selected bacteria. Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/ps\/82.4.627","article-title":"Application of prebiotics and probiotics in poultry production.","volume":"82","author":"Patterson","year":"2003","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0168-1656(00)00375-8","article-title":"Probiotic bacteria: Safety, functional and technological properties.","volume":"84","author":"Saarela","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.3382\/ps\/pex251_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1095-6433(02)00121-6","article-title":"Histological alterations of intestinal villi in chickens fed dried Bacillus subtilis var.","volume":"133","author":"Samanya","year":"2002","journal-title":"natto. Comp. Biochem. Physiol."},{"key":"10.3382\/ps\/pex251_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0378-1135(00)00193-0","article-title":"Dynamics of lymphocyte subpopulation changes in the cecal tonsils of chickens infected with Salmonella enteritidis.","volume":"74","author":"Sasai","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.3382\/ps\/pex251_bib30","first-page":"123","article-title":"Characterization and antibiogram of Salmonella spp.","volume":"2","author":"Selvaraj","year":"2010","journal-title":"from poultry specimens. J. Microbiol. Antimicrob."},{"key":"10.3382\/ps\/pex251_bib31","first-page":"670","article-title":"Immune responses against Salmonella enterica serovar enteritidis infection in virally immunosuppressed chickens.","volume":"10","author":"Sheela","year":"2003","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.3382\/ps\/pex251_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3382\/ps.0520197","article-title":"Influence of the implantation of Lactobacillus acidophilus in chicks on the growth, feed conversion, malabsorption of fats syndrome and intestinal flora.","volume":"52","author":"Tortuero","year":"1973","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex251_bib33","first-page":"185","article-title":"Immune response following vaccination against Salmonella Enteritidis using 2 commercial bacterins in laying hens.","volume":"74","author":"Tran","year":"2010","journal-title":"Can. J. Vet. Res."},{"key":"10.3382\/ps\/pex251_bib34","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/S0264-410X(02)00227-X","article-title":"The effect of vaccination with a Salmonella enteritidis aroA mutant on early cellular responses in caecal lamina propria of newly-hatched chickens.","volume":"20","author":"Van Immerseel","year":"2002","journal-title":"Vaccine."},{"key":"10.3382\/ps\/pex251_bib35","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0950268805004711","article-title":"Vaccination and early protection against non-host-specific Salmonella serotypes in poultry: Exploitation of innate immunity and microbial activity.","volume":"133","author":"Van Immerseel","year":"2005","journal-title":"Epidemiol Infect."},{"key":"10.3382\/ps\/pex251_bib36","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.3382\/ps.2012-02339","article-title":"Different combinations of probiotics improve the production performance, egg quality, and immune response of layer hens.","volume":"91","author":"Zhang","year":"2012","journal-title":"Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119312131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119312131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/96\/12\/4208\/22660847\/pex251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T20:42:10Z","timestamp":1758487330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579119312131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0032579119312131"],"URL":"https:\/\/doi.org\/10.3382\/ps\/pex251","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of synbiotic supplementation on layer production and cecal Salmonella load during a Salmonella challenge","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps\/pex251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}