{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:47:14Z","timestamp":1790934434221,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":551,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds","award":["KJQN201707"],"award-info":[{"award-number":["KJQN201707"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601973"],"award-info":[{"award-number":["31601973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160739"],"award-info":[{"award-number":["BK20160739"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M581816"],"award-info":[{"award-number":["2015M581816"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.3382\/ps\/pex408","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T20:16:31Z","timestamp":1518120991000},"page":"1209-1219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":137,"title":["Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens"],"prefix":"10.1016","volume":"97","author":[{"given":"J.F.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.W.","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.P.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3382\/ps\/pex408_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/00071660310001618334","article-title":"Effect of heat stress on oxidative stress, lipid peroxidation and some stress parameters in broilers","volume":"44","author":"Altan","year":"2003","journal-title":"Br. Poult. Sci."},{"key":"10.3382\/ps\/pex408_bib2","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.bcp.2008.08.008","article-title":"Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature","volume":"76","author":"Anand","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.3382\/ps\/pex408_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cbpa.2009.12.011","article-title":"Metabolic characteristics and oxidative damage to skeletal muscle in broiler chickens exposed to chronic heat stress","volume":"155","author":"Azad","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.3382\/ps\/pex408_bib4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1042\/bj20021619","article-title":"Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element","volume":"371","author":"Balogun","year":"2003","journal-title":"Biochem. J."},{"key":"10.3382\/ps\/pex408_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cbi.2008.05.009","article-title":"Concentration dependent antioxidant\/pro-oxidant activity of curcumin: Studies from AAPH induced hemolysis of RBCs","volume":"174","author":"Banerjee","year":"2008","journal-title":"Chem-Biol. Interact."},{"key":"10.3382\/ps\/pex408_bib6","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.2527\/jas.2008-1379","article-title":"Association of mitochondrial function and feed efficiency in poultry and livestock species","volume":"87","author":"Bottje","year":"2009","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps\/pex408_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jnutbio.2011.12.010","article-title":"Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity","volume":"24","author":"Carmona-Ramirez","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.3382\/ps\/pex408_bib8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.fitote.2011.04.003","article-title":"Hepatoprotective effect of curcumin in lipopolysaccharide\/-galactosamine model of liver injury in rats: relationship to HO-1\/CO antioxidant system","volume":"82","author":"Cern\u00fd","year":"2011","journal-title":"Fitoterapia"},{"key":"10.3382\/ps\/pex408_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijpara.2010.12.011","article-title":"Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters","volume":"41","author":"Charoensuk","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.3382\/ps\/pex408_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.freeradbiomed.2004.10.013","article-title":"Gene expression profiling of NRF2-mediated protection against oxidative injury","volume":"38","author":"Cho","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.3382\/ps\/pex408_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00204-010-0511-2","article-title":"Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats","volume":"84","author":"Elagamy","year":"2010","journal-title":"Arch. Toxicol."},{"key":"10.3382\/ps\/pex408_bib12","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.meatsci.2014.07.019","article-title":"pH inactivation of phosphofructokinase arrests postmortem glycolysis","volume":"98","author":"England","year":"2014","journal-title":"Meat Sci."},{"key":"10.3382\/ps\/pex408_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/ps\/86.3.538","article-title":"Physiological changes to transient exposure to heat stress observed in laying hens","volume":"86","author":"Franco-Jimenez","year":"2007","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex408_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bcp.2007.08.016","article-title":"Curcumin as \u201cCurecumin\u201d: From kitchen to clinic","volume":"75","author":"Goel","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.3382\/ps\/pex408_bib15","first-page":"790","article-title":"Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 2","volume":"91","author":"Gu","year":"2012","journal-title":"Intestinal oxidative stress. Poult. Sci."},{"key":"10.3382\/ps\/pex408_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/978-0-387-46401-5_21","article-title":"Clinical studies with curcumin","volume":"595","author":"Hsu","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.3382\/ps\/pex408_bib17","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.2527\/jas.2014-8739","article-title":"Heat stress impairs mitochondria functions and induces oxidative injury in broiler chickens","volume":"93","author":"Huang","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps\/pex408_bib18","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1089\/ars.2005.7.1728","article-title":"Evaluation for safety of antioxidant chemopreventive agents","volume":"7","author":"Kawanishi","year":"2005","journal-title":"Antioxid. Redox Sign."},{"key":"10.3382\/ps\/pex408_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1667\/RR1522.1","article-title":"Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice","volume":"173","author":"Lee","year":"2010","journal-title":"Radiat. Res."},{"key":"10.3382\/ps\/pex408_bib20","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.2527\/jas.2013-6538","article-title":"Effects of acute heat stress on gene expression of brain-gut neuropeptides in broiler chickens","volume":"91","author":"Lei","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps\/pex408_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbpa.2006.01.032","article-title":"Acute heat stress induces oxidative stress in broiler chickens","volume":"144","author":"Lin","year":"2006","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.3382\/ps\/pex408_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2009.04.007","article-title":"Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease","volume":"47","author":"Morse","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.3382\/ps\/pex408_bib23","first-page":"419","article-title":"Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: Evidence of its antioxidant property","author":"Naik","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.3382\/ps\/pex408_bib24","series-title":"Nutrient Requirements of Poultry","author":"National Research Council (NRC).","year":"1994"},{"key":"10.3382\/ps\/pex408_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.toxlet.2007.03.011","article-title":"Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element","volume":"170","author":"Nishinaka","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.3382\/ps\/pex408_bib26","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3382\/ps.2010-00812","article-title":"Heat stress impairs performance parameters, induces intestinal injury, and decreases macrophage activity in broiler chickens","volume":"89","author":"Quinteiro-Filho","year":"2010","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex408_bib27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/14786419.2014.956212","article-title":"Dual effect of curcumin in preventing atherosclerosis: The potential role of pro-oxidant-antioxidant mechanisms","volume":"29","author":"Sahebkar","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.3382\/ps\/pex408_bib28","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1016\/j.fct.2012.08.029","article-title":"Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2\/HO-1 pathway in quail","volume":"50","author":"Sahin","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.3382\/ps\/pex408_bib29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.freeradbiomed.2007.05.009","article-title":"Role of prooxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)","volume":"43","author":"Sandur","year":"2007","journal-title":"Free Radical Bio. Med."},{"key":"10.3382\/ps\/pex408_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-4274(99)00124-1","article-title":"The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells","volume":"109","author":"Singhal","year":"1999","journal-title":"Toxicol. Lett."},{"key":"10.3382\/ps\/pex408_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12640-011-9249-8","article-title":"Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain","volume":"20","author":"Sood","year":"2011","journal-title":"Neurotoxicity Res."},{"key":"10.3382\/ps\/pex408_bib32","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.lfs.2005.09.017","article-title":"Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse","volume":"78","author":"Valentine","year":"2006","journal-title":"Life Sci."},{"key":"10.3382\/ps\/pex408_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","article-title":"Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia","volume":"1282","author":"Yang","year":"2009","journal-title":"Brain Res."},{"key":"10.3382\/ps\/pex408_bib34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cbpc.2009.10.010","article-title":"Effects of acute heat stress and subsequent stress removal on function of hepatic mitochondrial respiration, ROS production and lipid peroxidation in broiler chickens","volume":"151","author":"Yang","year":"2010","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.3382\/ps\/pex408_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cbpa.2010.01.008","article-title":"Effect of heat stress on the porcine small intestine: A morphological and gene expression study","volume":"156","author":"Yu","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.3382\/ps\/pex408_bib36","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1079\/BJN19970088","article-title":"Effect of environmental temperature on muscle protein turnover and heat production in tube-fed broiler chickens","volume":"77","author":"Yunianto","year":"1997","journal-title":"Br. J. Nutr."},{"key":"10.3382\/ps\/pex408_bib37","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3945\/jn.114.193573","article-title":"Curcumin attenuates D-galactosamine\/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice","volume":"144","author":"Zhang","year":"2014","journal-title":"J. Nutr."},{"key":"10.3382\/ps\/pex408_bib38","first-page":"63","article-title":"Effect of various levels of dietary curcumin on meat quality and antioxidant profile of breast muscle in broilers","author":"Zhang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.3382\/ps\/pex408_bib39","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.2527\/jas.2014-8244","article-title":"Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway","volume":"93","author":"Zhang","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps\/pex408_bib40","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.3382\/ps.2011-01446","article-title":"Dietary sodium butyrate alleviates the oxidative stress induced by corticosterone exposure and improves meat quality in broiler chickens","volume":"90","author":"Zhang","year":"2011","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pex408_bib41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.canep.2010.06.012","article-title":"Nrf2-ARE signaling pathway and natural products for cancer chemoprevention","volume":"34","author":"Zhao","year":"2010","journal-title":"Cancer Epidemiol."},{"key":"10.3382\/ps\/pex408_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2012.09.010","article-title":"Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1\/2-Nrf2 pathway","volume":"1482","author":"Zhao","year":"2012","journal-title":"Brain Res."},{"key":"10.3382\/ps\/pex408_bib43","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.freeradbiomed.2007.04.016","article-title":"De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation","volume":"43","author":"Zheng","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.3382\/ps\/pex408_bib44","first-page":"36","article-title":"Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: Possible involvement of the ERK1\/2 pathway","volume":"104","author":"Zhou","year":"2010","journal-title":"Basic Clin. Pharm. Toxicol."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119309861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119309861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/97\/4\/1209\/24374072\/pex408.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T20:36:19Z","timestamp":1758486979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579119309861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0032579119309861"],"URL":"https:\/\/doi.org\/10.3382\/ps\/pex408","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps\/pex408","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}