{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:34:56Z","timestamp":1777894496611,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T00:00:00Z","timestamp":1569628800000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.3382\/ps\/pey484","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T02:38:30Z","timestamp":1538620710000},"page":"1146-1152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Zinc source influences the gene expression of zinc transporters in jejunum and cecal tonsils during broiler challenge with Eimeria maximaand Clostridium perfringens"],"prefix":"10.1016","volume":"98","author":[{"given":"B","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bortoluzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W D","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Graugnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Applegate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3382\/ps\/pey484_bib1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3899\/jrheum.140628","article-title":"Calprotectin as a biomarker for rheumatoid arthritis: a systematic review","volume":"42","author":"Abildtrup","year":"2015","journal-title":"J. Rheumatol."},{"key":"10.3382\/ps\/pey484_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1095-6433(00)80009-4","article-title":"Mechanisms of regulation of metallothionein gene expression","volume":"126","author":"Andrews","year":"2000","journal-title":"Comp. Biochem. Physiol. A: Mol. Integr. Physiol."},{"key":"10.3382\/ps\/pey484_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-1135(96)01289-8","article-title":"Clostridial population and the intestinal lesions in chickens infected with Clostridium perfringensand Eimeria necatrix","volume":"54","author":"Baba","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.3382\/ps\/pey484_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0076-6879(91)05080-F","article-title":"Nutritional and physiological significance of metallothionein","volume":"205","author":"Bremner","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.3382\/ps\/pey484_bib5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00018-002-8454-2","article-title":"Metallothionein: the multipurpose protein","volume":"59","author":"Coyle","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.3382\/ps\/pey484_bib6","series-title":"Guide for the Care and Use of Animals in Agricultural Research and Teaching","author":"Federation of Animal Science Societies (FASS)","year":"2010"},{"key":"10.3382\/ps\/pey484_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3390\/nu9060624","article-title":"Zinc in Infection and Inflammation","volume":"9","author":"Gammoh","year":"2017","journal-title":"Nutrients"},{"key":"10.3382\/ps\/pey484_bib8","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jnutbio.2011.07.005","article-title":"Comparison of intracellular zinc signals in nonadherent lymphocytes from young-adult and elderly donors: role of zinc transporters (Zip family) and proinflammatory cytokines","volume":"23","author":"Giacconi","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.3382\/ps\/pey484_bib9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.bi.55.070186.004405","article-title":"Metallothionein","volume":"55","author":"Hamer","year":"1986","journal-title":"Annu. Rev. Biochem."},{"key":"10.3382\/ps\/pey484_bib10","doi-asserted-by":"crossref","first-page":"26389","DOI":"10.1074\/jbc.M200462200","article-title":"Functional characterization of a novel mammalian zinc transporter, ZnT6","volume":"277","author":"Huang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.3382\/ps\/pey484_bib11","doi-asserted-by":"crossref","first-page":"1452S","DOI":"10.1093\/jn\/133.5.1452S","article-title":"Zinc-altered immune function","volume":"133","author":"Ibs","year":"2003","journal-title":"J. Nutr."},{"key":"10.3382\/ps\/pey484_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3923\/ijps.2011.225.230","article-title":"Effects of zinc supplementation on laying performance, serum chemistry and zn residue in tibia bone, liver, excreta and egg shell of laying hens","volume":"10","author":"Idowu","year":"2011","journal-title":"Int. J. Poult. Sci."},{"key":"10.3382\/ps\/pey484_bib13","doi-asserted-by":"crossref","first-page":"19049","DOI":"10.1074\/jbc.M200910200","article-title":"Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells","volume":"277","author":"Kambe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.3382\/ps\/pey484_bib14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jcp.22900","article-title":"Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation","volume":"227","author":"Kelleher","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.3382\/ps\/pey484_bib15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1572-0241.2007.01556.x","article-title":"Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices","volume":"103","author":"Langhorst","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.3382\/ps\/pey484_bib16","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/00365520701416709","article-title":"Serum and mucosal S100 proteins, calprotectin (S100A8\/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease","volume":"42","author":"Leach","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"10.3382\/ps\/pey484_bib17","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1073\/pnas.0502257102","article-title":"Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response","volume":"102","author":"Liuzzi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3382\/ps\/pey484_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3382\/ps\/pey484_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1079\/WPS200593","article-title":"Necrotic enteritis; a continuing challenge for the poultry industry","volume":"62","author":"McDevitt","year":"2006","journal-title":"Worlds Poult. Sci. J."},{"key":"10.3382\/ps\/pey484_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<257::AID-PATH756>3.0.CO;2-U","article-title":"Cytokines and the hepatic acute phase response","volume":"181","author":"Moshage","year":"1997","journal-title":"J. Pathol."},{"key":"10.3382\/ps\/pey484_bib21","series-title":"Nutrient Requirements of Poultry","author":"NRC","year":"1994"},{"key":"10.3382\/ps\/pey484_bib22","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3382\/ps.2012-02966","article-title":"Expression of digestive enzymes and nutrient transporters in the intestine of Eimeria maxima-infected chickens","volume":"92","author":"Paris","year":"2013","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pey484_bib23","first-page":"467","article-title":"Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease","volume":"90","author":"Quadri","year":"2012","journal-title":"Am. J. Med. Genet."},{"key":"10.3382\/ps\/pey484_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02795457","article-title":"Serum and liver zinc, copper, and iron in chicks infected with Eimeria acervulina or Eimeria tenella","volume":"17","author":"Richards","year":"1988","journal-title":"Biol. Trace Elem. Res."},{"key":"10.3382\/ps\/pey484_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3184\/175815508X334578","article-title":"Zinc in broiler feeding and nutrition","volume":"1","author":"Salim","year":"2008","journal-title":"Avian Biol Res"},{"key":"10.3382\/ps\/pey484_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00011-012-0559-y","article-title":"Zip14 expression induced by lipopolysaccharides in macrophages attenuates inflammatory response","volume":"62","author":"Sayadi","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.3382\/ps\/pey484_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2164-5-32","article-title":"In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters tissue expression","volume":"5","author":"Seve","year":"2004","journal-title":"BMC Genomics"},{"key":"10.3382\/ps\/pey484_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1297-9716-43-74","article-title":"The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review","volume":"43","author":"Shojadoost","year":"2012","journal-title":"Vet. Res."},{"key":"10.3382\/ps\/pey484_bib29","first-page":"1293","article-title":"Bioavailability and immunity response in broiler breeders on organically complexed zinc supplementation","volume":"4","author":"Soni","year":"2013","journal-title":"Food Sci. Nutr."},{"key":"10.3382\/ps\/pey484_bib30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1017\/S0043933914000531","article-title":"The efficacy of organic minerals in poultry nutrition: review and implications of recent studies","volume":"70","author":"\u015awi\u0105tkiewicz","year":"2014","journal-title":"Worlds Poult. Sci. J."},{"key":"10.3382\/ps\/pey484_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S0007114515001592","article-title":"The influence of dietary zinc source and coccidial vaccine exposure on intracellular zinc homeostasis and immune status in broiler chickens","volume":"114","author":"Troche","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.3382\/ps\/pey484_bib32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3382\/ps.0490523","article-title":"Effects of serial inoculations with Eimeria acervulinaor Eimeria necatrixupon zinc and oleic acid absorption in chicks","volume":"49","author":"Turk","year":"1970","journal-title":"Poult. Sci."},{"key":"10.3382\/ps\/pey484_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ajhg.2012.01.018","article-title":"Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10 , a manganese transporter in man","volume":"90","author":"Tuschl","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.3382\/ps\/pey484_bib34","first-page":"56","article-title":"Clostridial enteritis - A syndrome emerging world-wide","volume":"16","author":"Van Der Sluis","year":"2000","journal-title":"World Poult."},{"key":"10.3382\/ps\/pey484_bib35","first-page":"42","article-title":"Clostridial enteritis is an often underestimated problem","volume":"16","author":"Van Der Sluis","year":"2000","journal-title":"World Poult."},{"key":"10.3382\/ps\/pey484_bib36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/hmg\/ddh049","article-title":"Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter","volume":"13","author":"Wang","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.3382\/ps\/pey484_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jnutbio.2012.07.005","article-title":"Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation","volume":"24","author":"Wong","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.3382\/ps\/pey484_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1369\/jhc.6A7032.2006","article-title":"Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract","volume":"55","author":"Yu","year":"2007","journal-title":"J Histochem. Cytochem."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119303876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119303876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/98\/3\/1146\/27789241\/pey484.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T20:35:44Z","timestamp":1758486944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579119303876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0032579119303876"],"URL":"https:\/\/doi.org\/10.3382\/ps\/pey484","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc source influences the gene expression of zinc transporters in jejunum and cecal tonsils during broiler challenge with Eimeria maximaand Clostridium perfringens","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps\/pey484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}