{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:22:08Z","timestamp":1791249728956,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:00:00Z","timestamp":1570838400000},"content-version":"vor","delay-in-days":2628,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3382\/ps.2012-02236","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T10:46:57Z","timestamp":1342608417000},"page":"1997-2003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters"],"prefix":"10.1016","volume":"91","author":[{"given":"M.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3382\/ps.2012-02236_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2141\/jpsa.010058","article-title":"Changes in the density of immunoreactive avian \u03b2-defensin-3 and \u221211 in the hen uterus in response to lipopolysaccharide inoculation","volume":"48","author":"Abdel Mageed","year":"2011","journal-title":"J. Poult. Sci."},{"key":"10.3382\/ps.2012-02236_bib2","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3382\/ps.2011-01394","article-title":"Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and influx of leukocytes in hen ovary","volume":"90","author":"Abdelsalam","year":"2011","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2012-02236_bib3","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.virol.2009.08.001","article-title":"Induction of innate host responses in the lungs of chickens following infection with a very virulent strain of Marek's disease virus","volume":"93","author":"Abdul-Careem","year":"2009","journal-title":"Virology"},{"key":"10.3382\/ps.2012-02236_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.anireprosci.2011.09.003","article-title":"Changes in the expression of Toll-like receptors in the chicken testis during sexual maturation and Salmonella infection","volume":"128","author":"Anastasiadou","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.3382\/ps.2012-02236_bib5","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1128\/jvi.67.6.3528-3533.1993","article-title":"Transformation- associated cytokine 9E3\/CEF4 is chemotactic for chicken peripheral blood mononuclear cells","volume":"67","author":"Barker","year":"1993","journal-title":"J. Virol."},{"key":"10.3382\/ps.2012-02236_bib6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1637\/7654-052506R.1","article-title":"Epididymal stone formation and decreased sperm production in roosters vaccinated with a killed strain of avian infectious bronchitis virus","volume":"50","author":"Boltz","year":"2006","journal-title":"Avian Dis."},{"key":"10.3382\/ps.2012-02236_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-010-1026-0","article-title":"Avian toll-like receptors","volume":"343","author":"Brownlie","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.3382\/ps.2012-02236_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/82763","article-title":"IL-6 switches the differentiation of monocytes from dendritic cells to macrophages","volume":"1","author":"Chomarat","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.3382\/ps.2012-02236_bib9","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1073\/pnas.1018135108","article-title":"Cleavage and activation of a Toll-like receptor by microbial proteases","volume":"108","author":"de Zoete","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3382\/ps.2012-02236_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1074-7613(00)00078-9","article-title":"Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1","volume":"13","author":"Diehl","year":"2000","journal-title":"Immunity"},{"key":"10.3382\/ps.2012-02236_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1017\/S0950268804002687","article-title":"Heterophils isolated from chickens resistant to extraintestinal Salmonella enteritidis infection express higher levels of proinflammatory cytokine mRNA following infection than heterophils from susceptible chickens","volume":"132","author":"Ferro","year":"2004","journal-title":"Epidemiol. Infect."},{"key":"10.3382\/ps.2012-02236_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.iy.06.040188.002413","article-title":"Molecular regulation of B lymphocyte response","volume":"6","author":"Kishimoto","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"10.3382\/ps.2012-02236_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/10495390500264896","article-title":"Lipopolysaccharide binding protein\/CD14\/ TLR4-dependent recognition of Salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells","volume":"16","author":"Kogut","year":"2005","journal-title":"Anim. Biotechnol."},{"key":"10.3382\/ps.2012-02236_bib14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.dci.2005.02.002","article-title":"Expression and function of Toll-like receptors in chicken heterophils","volume":"29","author":"Kogut","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"10.3382\/ps.2012-02236_bib15","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.micinf.2006.02.026","article-title":"Toll-like receptor agonists stimulate differential functional activation and cytokine and chemokine gene expression in heterophils isolated from chickens with differential innate responses","volume":"8","author":"Kogut","year":"2006","journal-title":"Microbes Infect."},{"key":"10.3382\/ps.2012-02236_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u03b4\u03b4CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3382\/ps.2012-02236_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00251-008-0346-7","article-title":"Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens","volume":"61","author":"Meade","year":"2009","journal-title":"Immunogenetics"},{"key":"10.3382\/ps.2012-02236_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11259-010-9420-3","article-title":"Expression of chicken LEAP-2 in the reproductive organs and embryos and in response to Salmonella enterica infection","volume":"34","author":"Michailidis","year":"2010","journal-title":"Vet. Res. Commun."},{"key":"10.3382\/ps.2012-02236_bib19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.anireprosci.2010.09.004","article-title":"Transcriptional profiling of Toll-like receptors in chicken embryos and in the ovary during sexual maturation and in response to Salmonella enteritidis infection","volume":"122","author":"Michailidis","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"10.3382\/ps.2012-02236_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.anireprosci.2011.01.010","article-title":"Effects of sexual maturation and Salmonella infection on the expression of Toll-like receptors in the chicken vagina","volume":"123","author":"Michailidis","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.3382\/ps.2012-02236_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0264-410X(01)00270-5","article-title":"Adjuvant effects of IL-1\u03b2, IL-2, IL-8, IL-15, IFN-\u03b1, IFN-\u03b3 TGF-\u03b24 and lymphotactin on DNA vaccination against Eimeria acervulina","volume":"20","author":"Min","year":"2002","journal-title":"Vaccine"},{"key":"10.3382\/ps.2012-02236_bib22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/03079450802499134","article-title":"Bacterial orchitis and epididymo-orchitis in broiler breeders","volume":"37","author":"Monleon","year":"2008","journal-title":"Avian Pathol."},{"key":"10.3382\/ps.2012-02236_bib23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1292\/jvms.53.727","article-title":"Macrophages in the rete testis of pubertal male fowl","volume":"53","author":"Nakai","year":"1991","journal-title":"J. Vet. Med. Sci."},{"key":"10.3382\/ps.2012-02236_bib24","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.3382\/ps.2011-01596","article-title":"Effects of lipopolysaccharide on the expression of proinflamatory cytokines and chemokines and the subsequent recruitment of immunocompetent cells in the oviduct of laying and molting hens","volume":"90","author":"Nii","year":"2011","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2012-02236_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetimm.2008.10.325","article-title":"Expression of Toll-like receptors (TLRs) and TLR4 response to lipopolysaccharide in hen oviduct","volume":"127","author":"Ozoe","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3382\/ps.2012-02236_bib26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1095\/biolreprod.106.059410","article-title":"Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract","volume":"76","author":"Palladino","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.3382\/ps.2012-02236_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1600-0897.2008.00654.x","article-title":"Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa","volume":"60","author":"Palladino","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.3382\/ps.2012-02236_bib28","doi-asserted-by":"crossref","first-page":"16408","DOI":"10.1074\/jbc.M800998200","article-title":"Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF\/INTERLEUKIN-8) are ligands for this receptor","volume":"283","author":"Poh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.3382\/ps.2012-02236_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.vetimm.2011.01.006","article-title":"Proportion of circulating chicken heterophils and CXCLi2 expression in response to Salmonella enteritidis are affected by genetic line and immune modulating diet","volume":"140","author":"Redmond","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3382\/ps.2012-02236_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jri.2005.10.006","article-title":"Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis","volume":"70","author":"Rival","year":"2006","journal-title":"J. Reprod. Immunol."},{"key":"10.3382\/ps.2012-02236_bib31","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/107999001317205123","article-title":"Cytokines of birds: Conserved function\u2014A largely different look","volume":"21","author":"Staeheli","year":"2001","journal-title":"J. Interferon Cytokine Res."},{"key":"10.3382\/ps.2012-02236_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/REP-06-0083","article-title":"Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus)","volume":"133","author":"Subedi","year":"2007","journal-title":"Reproduction"},{"key":"10.3382\/ps.2012-02236_bib33","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1262\/jrd.19076","article-title":"Changes in the expression of toll-like receptor mRNAs during follicular growth and in response to lipopolysaccharide in the ovarian follicles of laying hens","volume":"53","author":"Subedi","year":"2007","journal-title":"J. Reprod. Dev."},{"key":"10.3382\/ps.2012-02236_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jri.2006.05.001","article-title":"Cytokines in reproductive remodeling of molting White Leghorn hens","volume":"73","author":"Sundaresan","year":"2007","journal-title":"J. Reprod. Immunol."},{"key":"10.3382\/ps.2012-02236_bib35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00441-008-0599-3","article-title":"High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression","volume":"332","author":"Sundaresan","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.3382\/ps.2012-02236_bib36","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2164-9-62","article-title":"Evolution of the chicken Toll-like receptor gene family: A story of gene again and gene loss","volume":"9","author":"Temperley","year":"2008","journal-title":"BMC Genomics"},{"key":"10.3382\/ps.2012-02236_bib37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1637\/7815-121306-REGR4.1","article-title":"Orchitis in roosters with reduced fertility associated with avian infectious bronchitis virus and avian metapneumovirus infections","volume":"51","author":"Villarreal","year":"2007","journal-title":"Avian Dis."},{"key":"10.3382\/ps.2012-02236_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2141\/jpsa.011042","article-title":"Detection of avian beta-defensins mRNA and proteins in male reproductive organs in chicken","volume":"48","author":"Watanabe","year":"2011","journal-title":"J. Poult. Sci."},{"key":"10.3382\/ps.2012-02236_bib39","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1530\/REP-08-0320","article-title":"Toll-like receptor signaling in hen ovarian granulosa cells is dependent on stage of follicle maturation","volume":"137","author":"Woods","year":"2009","journal-title":"Reproduction"},{"key":"10.3382\/ps.2012-02236_bib40","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1210\/en.2007-1776","article-title":"Expression patterns and functions of toll-like receptors in mouse sertoli cells","volume":"149","author":"Wu","year":"2008","journal-title":"Endocrinology"},{"key":"10.3382\/ps.2012-02236_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2141\/jpsa.41.315","article-title":"Immunolocalization of lymphocyte subsets in the testis and epididymis of roosters","volume":"41","author":"Yoshimura","year":"2004","journal-title":"J. Poult. Sci."}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257911939652X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257911939652X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/91\/8\/1997\/4432132\/poultrysci91-1997.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T21:15:20Z","timestamp":1758489320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257911939652X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S003257911939652X"],"URL":"https:\/\/doi.org\/10.3382\/ps.2012-02236","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps.2012-02236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}