{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:56:38Z","timestamp":1777532198864,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":2138,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.3382\/ps.2013-03420","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T15:09:53Z","timestamp":1384441793000},"page":"3214-3227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Expression and identification of recombinant chicken vascular endothelial growth factor in Pichia pastoris and its role in the pathogenesis of tibial dyschondroplasia"],"prefix":"10.1016","volume":"92","author":[{"given":"J.-P.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-F.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-L.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-F.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3382\/ps.2013-03420_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/dbio.1996.9989","article-title":"A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation","volume":"176","author":"Alini","year":"1996","journal-title":"Dev. Biol."},{"key":"10.3382\/ps.2013-03420_bib2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0736-0266(01)00120-6","article-title":"Identification of the metalloproteinase stromelysin in the physis","volume":"20","author":"Armstrong","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.3382\/ps.2013-03420_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/1523-1747.ep12522728","article-title":"Biochemical modulation of angiogenesis in the chorioallantoic membrane of the chick embryo","volume":"81","author":"Barnhill","year":"1983","journal-title":"J. Invest. Dermatol."},{"key":"10.3382\/ps.2013-03420_bib4","first-page":"106","article-title":"Type X collagen in avian tibial dyschondroplasia","volume":"60","author":"Bashey","year":"1989","journal-title":"Lab. Invest."},{"key":"10.3382\/ps.2013-03420_bib5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bone.2006.09.024","article-title":"VEGF and VEGF receptors are differentially expressed in chondrocytes","volume":"40","author":"Bluteau","year":"2007","journal-title":"Bone"},{"key":"10.3382\/ps.2013-03420_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1242\/jcs.113.1.59","article-title":"Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: Auto-paracrine role during endochondral bone formation","volume":"113","author":"Carlevaro","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.3382\/ps.2013-03420_bib7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.3382\/ps.2013-03420_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-483X(01)00401-2","article-title":"Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death","volume":"163","author":"Cereser","year":"2001","journal-title":"Toxicology"},{"key":"10.3382\/ps.2013-03420_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/dbio.2000.9933","article-title":"Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones","volume":"229","author":"Colnot","year":"2001","journal-title":"Dev. Biol."},{"key":"10.3382\/ps.2013-03420_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10238-011-0170-5","article-title":"Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts","volume":"13","author":"Corrado","year":"2013","journal-title":"Clin. Exp. Med."},{"key":"10.3382\/ps.2013-03420_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.joca.2004.02.003","article-title":"Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent","volume":"12","author":"Cramer","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.3382\/ps.2013-03420_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/MB:16:1:23","article-title":"Recombinant protein expression in Pichia pastoris","volume":"16","author":"Cregg","year":"2000","journal-title":"Mol. Biotechnol."},{"key":"10.3382\/ps.2013-03420_bib13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1177\/154405910708601006","article-title":"VEGF: An essential mediator of both angiogenesis and endochondral ossification","volume":"86","author":"Dai","year":"2007","journal-title":"J. Dent. Res."},{"key":"10.3382\/ps.2013-03420_bib14","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.2527\/jas.2009-2068","article-title":"Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate","volume":"87","author":"Dan","year":"2009","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps.2013-03420_bib15","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1210\/endo.141.5.7458","article-title":"Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation","volume":"141","author":"Deckers","year":"2000","journal-title":"Endocrinology"},{"key":"10.3382\/ps.2013-03420_bib16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.151.4.879","article-title":"Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones","volume":"151","author":"Engsig","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.3382\/ps.2013-03420_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0002-9440(10)63808-4","article-title":"Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage","volume":"162","author":"Enomoto","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.3382\/ps.2013-03420_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(95)90487-5","article-title":"Toward a molecular understanding of skeletal development","volume":"80","author":"Erlebacher","year":"1995","journal-title":"Cell"},{"key":"10.3382\/ps.2013-03420_bib19","series-title":"The Growth Plate, Biomedical and Health Research, 54","first-page":"201","article-title":"Tibial dyschondroplasia: A growth plate abnormality caused by delayed terminal differentiation","author":"Farquharson","year":"2002"},{"key":"10.3382\/ps.2013-03420_bib20","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/ps\/79.7.994","article-title":"Chondrocytes and longitudinal bone growth: The development of tibial dyschondroplasia","volume":"79","author":"Farquharson","year":"2000","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000046610","article-title":"The role of vascular endothelial growth factor in angiogenesis","volume":"106","author":"Ferrara","year":"2001","journal-title":"Acta Haematol."},{"key":"10.3382\/ps.2013-03420_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3382\/ps.2013-03420_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/03079450701591387","article-title":"Immunolocalization of vascularization factors in normal, tibial dyschondroplasia and rachitic cartilage","volume":"36","author":"Gay","year":"2007","journal-title":"Avian Pathol."},{"key":"10.3382\/ps.2013-03420_bib24","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3382\/ps.2012-02207","article-title":"The effect of inhibition of heat-shock proteins on thiram-induced tibial dyschondroplasia","volume":"91","author":"Genin","year":"2012","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1050-1738(00)00074-8","article-title":"Angiogenesis and bone growth","volume":"10","author":"Gerber","year":"2000","journal-title":"Trends Cardiovasc. Med."},{"key":"10.3382\/ps.2013-03420_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat. Med."},{"key":"10.3382\/ps.2013-03420_bib27","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.2527\/jas.2007-0738","article-title":"Expression of matrix metalloproteinases during vascularization and ossification of normal and impaired avian growth plate","volume":"86","author":"Hasky-Negev","year":"2008","journal-title":"J. Anim. Sci."},{"key":"10.3382\/ps.2013-03420_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(00)80064-1","article-title":"MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover","volume":"99","author":"Holmbeck","year":"1999","journal-title":"Cell"},{"key":"10.3382\/ps.2013-03420_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ar.1092290404","article-title":"Rearrangement of the metaphyseal vasculature of the rat growth plate in rickets and rachitic reversal: A model of vascular arrest and angiogenesis renewed","volume":"229","author":"Hunter","year":"1991","journal-title":"Anat. Rec."},{"key":"10.3382\/ps.2013-03420_bib30","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1073\/pnas.0407788101","article-title":"Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification","volume":"101","author":"Inada","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3382\/ps.2013-03420_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1097-0177(199904)214:4<279::AID-AJA1>3.0.CO;2-W","article-title":"Maturational disturbance of chondrocytes in Cbfa1-deficient mice","volume":"214","author":"Inada","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.3382\/ps.2013-03420_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/mvre.1996.0002","article-title":"Quantitation of angiogenesis in the chick chorioallantoic membrane model using fractal analysis","volume":"51","author":"Kirchner","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.3382\/ps.2013-03420_bib33","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"10.3382\/ps.2013-03420_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2307\/1590811","article-title":"Acid phosphatase activity of chondroclasts from Fusarium-induced tibial dyschondroplastic cartilage","volume":"32","author":"Lawler","year":"1988","journal-title":"Avian Dis."},{"key":"10.3382\/ps.2013-03420_bib35","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/ps\/86.10.2053","article-title":"Tibial dyschondroplasia 40 years later","volume":"86","author":"Leach","year":"2007","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/jn\/86.3.236","article-title":"Nutritional genetic and morphological studies of an abnormal cartilage formation in young chicks","volume":"86","author":"Leach","year":"1965","journal-title":"J. Nutr."},{"key":"10.3382\/ps.2013-03420_bib37","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1074\/jbc.M112.340232","article-title":"Runx2 protein stabilizes hypoxia-inducible factor-1 alpha through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.3382\/ps.2013-03420_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jor.21492","article-title":"Vascular endothelial growth factor polymorphisms in patients with steroid-induced femoral head osteonecrosis","volume":"30","author":"Lee","year":"2012","journal-title":"J. Orthop. Res."},{"key":"10.3382\/ps.2013-03420_bib39","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/00071660701665858","article-title":"Effect of diet with thiram on liver antioxidant capacity and tibial dyschondroplasia in broilers","volume":"48","author":"Li","year":"2007","journal-title":"Br. Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12010-007-0003-x","article-title":"Expression of recombinant proteins in Pichia pastoris","volume":"142","author":"Li","year":"2007","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.3382\/ps.2013-03420_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real- time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3382\/ps.2013-03420_bib42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","article-title":"Endochondral ossification: How cartilage is converted into bone in the developing skeleton","volume":"40","author":"Mackie","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.3382\/ps.2013-03420_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0925-4773(01)00601-3","article-title":"Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188)","volume":"111","author":"Maes","year":"2002","journal-title":"Mech. Dev."},{"key":"10.3382\/ps.2013-03420_bib44","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI200419383","article-title":"Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival","volume":"113","author":"Maes","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.3382\/ps.2013-03420_bib45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/sj.bjc.6600078","article-title":"Thiram inhibits angiogenesis and slows the development of experimental tumours in mice","volume":"86","author":"Marikovsky","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.3382\/ps.2013-03420_bib46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S8756-3282(01)00690-1","article-title":"Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts","volume":"30","author":"Mayr-Wohlfart","year":"2002","journal-title":"Bone"},{"key":"10.3382\/ps.2013-03420_bib47","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-5793(00)01520-9","article-title":"Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts","volume":"473","author":"Nakagawa","year":"2000","journal-title":"FEBS Lett."},{"key":"10.3382\/ps.2013-03420_bib48","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/030098589403100401","article-title":"Avian tibial dyschondroplasia: A morphological and biochemical review of the growth plate lesion and its causes","volume":"31","author":"Orth","year":"1994","journal-title":"Vet. Pathol."},{"key":"10.3382\/ps.2013-03420_bib49","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/ps\/79.7.1009","article-title":"Gene expression and tibial dyschondroplasia","volume":"79","author":"Praul","year":"2000","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib50","first-page":"621","article-title":"Chondrocytes of the tibial dyschondroplastic lesion are apoptotic","volume":"41","author":"Praul","year":"1997","journal-title":"Int. J. Dev. Biol."},{"key":"10.3382\/ps.2013-03420_bib51","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2004.11.068","article-title":"Molecular mechanisms of endochondral bone development","volume":"328","author":"Provot","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3382\/ps.2013-03420_bib52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.1527","article-title":"Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes","volume":"202","author":"Pufe","year":"2004","journal-title":"J. Pathol."},{"key":"10.3382\/ps.2013-03420_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2131\/jts.38.93","article-title":"Effect of thiram on avian growth plate chondrocytes in culture","volume":"38","author":"Rasaputra","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.3382\/ps.2013-03420_bib54","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/ps\/76.3.501","article-title":"Matrix metalloproteinase activities in avian tibial dyschondroplasia","volume":"76","author":"Rath","year":"1997","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/ps\/83.2.266","article-title":"Comparative efficacy of different dithiocarbamates to induce tibial dyschondroplasia in poultry","volume":"83","author":"Rath","year":"2004","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib56","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3382\/ps.2007-00219","article-title":"Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia","volume":"86","author":"Rath","year":"2007","journal-title":"Poult. Sci."},{"key":"10.3382\/ps.2013-03420_bib57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcpa.2005.01.005","article-title":"Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia","volume":"133","author":"Rath","year":"2005","journal-title":"J. Comp. Pathol."},{"key":"10.3382\/ps.2013-03420_bib58","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1210\/jcem-66-6-1124","article-title":"Skeletal blood flow, iliac histomorphometry, and strontium kinetics in osteoporosis: A relationship between blood flow and corrected apposition rate","volume":"66","author":"Reeve","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.3382\/ps.2013-03420_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2307\/1589359","article-title":"Studies on the pathogeneis of tibial dyschondroplasia in chickens. IV. Some features of the vascular supply to the growth plates of the tibiotarsus","volume":"21","author":"Riddell","year":"1977","journal-title":"Avian Dis."},{"key":"10.3382\/ps.2013-03420_bib60","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3382\/ps.2013-03420_bib61","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ydbio.2009.05.552","article-title":"Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation","volume":"332","author":"Takimoto","year":"2009","journal-title":"Dev. Biol."},{"key":"10.3382\/ps.2013-03420_bib62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cardiores.2004.12.002","article-title":"The biology of vascular endothelial growth factors","volume":"65","author":"Tammela","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.3382\/ps.2013-03420_bib63","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00418-005-0773-6","article-title":"Vascular endothelial growth factor plays an important autocrine\/paracrine role in the progression of osteoarthritis","volume":"123","author":"Tanaka","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.3382\/ps.2013-03420_bib64","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jcpa.2010.12.008","article-title":"Expression of genes encoding extracellular matrix macromolecules and metalloproteinases in avian tibial dyschondroplasia","volume":"145","author":"Velada","year":"2011","journal-title":"J. Comp. Pathol."},{"key":"10.3382\/ps.2013-03420_bib65","first-page":"174a","article-title":"Angiogenesis during endochondral bone formation is regulated by vascular endothelial growth factor (VEGF)","volume":"9","author":"Vu","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.3382\/ps.2013-03420_bib66","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1359\/jbmr.2002.17.4.639","article-title":"Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization","volume":"17","author":"Wu","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.3382\/ps.2013-03420_bib67","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","article-title":"Vascular-specific growth factors and blood vessel formation","volume":"407","author":"Yancopoulos","year":"2000","journal-title":"Nature"},{"key":"10.3382\/ps.2013-03420_bib68","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.matbio.2008.06.005","article-title":"VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and beta(3)-integrin","volume":"27","author":"Yang","year":"2008","journal-title":"Matrix Biol."},{"key":"10.3382\/ps.2013-03420_bib69","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.archoralbio.2005.12.006","article-title":"Effect of vascular endothelial growth factor on RANK gene expression in osteoclast precursors and on osteoclastogenesis","volume":"51","author":"Yao","year":"2006","journal-title":"Arch. Oral Biol."},{"key":"10.3382\/ps.2013-03420_bib70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0925-4773(01)00428-2","article-title":"Tissue specific regulation of VEGF expression during bone development requires Cbfa1\/Runx2","volume":"106","author":"Zelzer","year":"2001","journal-title":"Mech. Dev."},{"key":"10.3382\/ps.2013-03420_bib71","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0070-2153(04)65006-X","article-title":"Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair","volume":"65","author":"Zelzer","year":"2005","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.3382\/ps.2013-03420_bib72","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1073\/pnas.060037197","article-title":"Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I","volume":"97","author":"Zhou","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257911938441X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003257911938441X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/92\/12\/3214\/4496227\/poultrysci92-3214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T21:10:22Z","timestamp":1758489022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003257911938441X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":72,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S003257911938441X"],"URL":"https:\/\/doi.org\/10.3382\/ps.2013-03420","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and identification of recombinant chicken vascular endothelial growth factor in Pichia pastoris and its role in the pathogenesis of tibial dyschondroplasia","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3382\/ps.2013-03420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}