{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:38:57Z","timestamp":1776843537281,"version":"3.51.2"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62071099 62371112"],"award-info":[{"award-number":["62071099 62371112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioinform."],"abstract":"<jats:p>Phage-immunoprecipitation sequencing (PhIP-Seq) technology is an innovative, high-throughput antibody detection method. It enables comprehensive analysis of individual antibody profiles. This technology shows great potential, particularly in exploring disease mechanisms and immune responses. Currently, PhIP-Seq has been successfully applied in various fields, such as the exploration of biomarkers for autoimmune diseases, vaccine development, and allergen detection. A variety of bioinformatics tools have facilitated the development of this process. However, PhIP-Seq technology still faces many challenges and has room for improvement. Here, we review the methods, applications, and challenges of PhIP-Seq and discuss its future directions in immunological research and clinical applications. With continuous progress and optimization, PhIP-Seq is expected to play an even more important role in future biomedical research, providing new ideas and methods for disease prevention, diagnosis, and treatment.<\/jats:p>","DOI":"10.3389\/fbinf.2024.1424202","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:12:49Z","timestamp":1725426769000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["PhIP-Seq: methods, applications and challenges"],"prefix":"10.3389","volume":"4","author":[{"given":"Ziru","family":"Huang","sequence":"first","affiliation":[]},{"given":"Samarappuli Mudiyanselage Savini","family":"Gunarathne","sequence":"additional","affiliation":[]},{"given":"Wenwen","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Yuwei","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Yuqing","family":"Jiang","sequence":"additional","affiliation":[]},{"given":"Shiqi","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.immuni.2023.04.003","article-title":"Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire","volume":"56","author":"Andreu-S\u00e1nchez","year":"2023","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1093\/ibd\/zaa010.109","article-title":"8 role of the host immune response to enteric prokaryotic viruses in inflammatory bowel disease","volume":"26","author":"Angkeow","year":"2020","journal-title":"Inflamm. 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