{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:06:51Z","timestamp":1772244411663,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioinform."],"abstract":"<jats:p>Reconstructing the global Tree of Life necessitates computational approaches to integrate numerous molecular phylogenies with limited species overlap into a comprehensive supertree. Our survey of published literature shows that individual phylogenies are frequently restricted to specific taxonomic groups due to investigators\u2019 expertise and molecular evolutionary considerations, resulting in any given species present in a minuscule fraction of phylogenies. We present a novel approach, called the chronological supertree algorithm (Chrono-STA), that can build a supertree of species from such data by using node ages in published molecular phylogenies scaled to time. Chrono-STA builds a supertree by integrating chronological data from molecular timetrees. It fundamentally differs from existing approaches that generate consensus phylogenies from gene trees with missing taxa, as Chrono-STA does not impute nodal distances, use a guide tree as a backbone, or reduce phylogenies to quartets. Analyses of simulated and empirical datasets show that Chrono-STA can combine taxonomically restricted timetrees with extremely limited species overlap. For such data, approaches that impute missing distances or assemble phylogenetic quartets did not perform well. We conclude that integrating phylogenies via temporal dimension enhances the accuracy of reconstructed supertrees that are also scaled to time.<\/jats:p>","DOI":"10.3389\/fbinf.2025.1571568","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T01:38:26Z","timestamp":1745977106000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrating phylogenies with chronology to assemble the tree of life"],"prefix":"10.3389","volume":"5","author":[{"given":"Jose","family":"Barba-Montoya","sequence":"first","affiliation":[]},{"given":"Jack M.","family":"Craig","sequence":"additional","affiliation":[]},{"given":"Sudhir","family":"Kumar","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"B1","first-page":"149","article-title":"Inferring orthology and paralogy","volume-title":"Methods in molecular Biology","author":"Altenhoff","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41586-021-04341-1","article-title":"A species-level timeline of mammal evolution integrating phylogenomic data","volume":"602","author":"\u00c1lvarez-Carretero","year":"2022","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1225807","DOI":"10.3389\/fbinf.2023.1225807","article-title":"Molecular timetrees using relaxed clocks and uncertain phylogenies","volume":"3","author":"Barba-Montoya","year":"2023","journal-title":"Front. 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