{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:08:34Z","timestamp":1773198514844,"version":"3.50.1"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007421","name":"University of the Philippines","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006001","name":"Ateneo de Manila University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioinform."],"abstract":"<jats:p>\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    phytochemicals were predicted to target insulin resistance proteins using a modified network pharmacology and molecular docking approach. Two hundred ninety\n                    <jats:italic>M. oleifera<\/jats:italic>\n                    phytochemicals with their aglycones, acetylase and myrosinase degradation products were compiled from literature and phytochemical databases. Nine protein targets were identified from the intersection of gene lists with high relevance to insulin resistance from GeneCards and DisGeNET and the target genes predicted by reverse screening using Swiss Target Prediction: protein-tyrosine phosphatase 1B (PTPN1), 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1), peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3), PI3-kinase p85-alpha subunit (PIK3R1), insulin receptor (INSR), tumor necrosis factor \u03b1 (TNF-\u03b1), endothelial nitric oxide synthase (eNOS) and hepatic lipase (LIPC). Binding affinities of phytochemicals with the targets were predicted using Autodock Vina. The predicted binding affinities were classified according to calculated thresholds using receiver operating characteristic (ROC) calculations of binding affinities of: (a) binders (annotated drugs and other molecules with known interaction with each target), and (b) decoys (molecules not expected to bind to a specific target). In addition, ubiquitous phytochemicals were filtered out to differentiate the effect on insulin resistance of\n                    <jats:italic>M. oleifera<\/jats:italic>\n                    from that of other plants. The resulting phytochemical-protein interaction network was visualized using Cytoscape. All mentioned targets, except hepatic lipase, were key targets based on various network centrality measures. Previous studies on murine models have shown that isothiocyanate-rich\n                    <jats:italic>M. oleifera<\/jats:italic>\n                    extracts ameliorate insulin resistance. Using our approach, the following phytochemicals, with predicted moderate bioavailability, high GI absorption, and probable binding with insulin resistance targets, are recommended for further\n                    <jats:italic>in vivo<\/jats:italic>\n                    or\n                    <jats:italic>in vitro<\/jats:italic>\n                    validation for insulin resistance activity: boldione (a steroid); aurantiamide acetate and aurantiamide (peptide derivatives); O-ethyl-[(3,4-dihydroxyphenyl)methyl] carbamothioate and O-methyl-N-[(4-hydroxyphenyl)methyl] carbamothioate (thiocarbamates); 4\u03b1,6\u03b1-dihydroxyeudesman-8\u03b2,12-olide (a sesquiterpenoid); sanleng acid and tianshic acid (fatty acid derivatives); 2\u2032,5,5\u2032,7-tetrahydroxyflavone; 2\u2032,3,5,7-tetrahydroxyflavone; and 6-hydroxykaempferol (flavonoids). By combining network centrality measures of targets, using ROC-derived thresholds for docking energies, and considering ubiquity of phytochemicals, our refined network pharmacology approach may aid in discovering key bioactive phytochemicals as potential chemical markers for standardization and differentiation of an herbal drug.\n                  <\/jats:p>","DOI":"10.3389\/fbinf.2026.1756081","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:43:45Z","timestamp":1773125025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance"],"prefix":"10.3389","volume":"6","author":[{"given":"Armi Katrina","family":"Santos-Enriquez","sequence":"first","affiliation":[{"name":"Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila","place":["Manila, Philippines"]},{"name":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","place":["Quezon City, Philippines"]}]},{"given":"Fabian M.","family":"Dayrit","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","place":["Quezon City, Philippines"]}]},{"given":"Armando Jerome","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","place":["Quezon City, Philippines"]}]},{"given":"Nina Rosario L.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","place":["Quezon City, Philippines"]}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fphar.2018.00108","article-title":"Moringa genus: a review of phytochemistry and pharmacology","volume":"9","author":"Abd Rani","year":"2018","journal-title":"Front. 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